Use of GnRH Antagonists as Physiologic Probes in the Female
The development of GnRH antagonists has provided investigators studying reproductive hormones with unique opportunities that have not been available for the study of other hormonal systems. Although GnRH antagonists have been used to advantage in basic studies and in animal models, they are particularly important tools for clinical investigation because of the relatively restricted number of models with which basic physiologic and pathophysiologic questions can be addressed in the human and the additional opportunities that GnRH antagonists have afforded.
KeywordsCorpus Luteum GnRH Antagonist GnRH Analog GnRH Receptor GnRH Secretion
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- 7.Hall JE, Crowley WF Jr. Use of a GnRH antagonist as a physiologic probe of GnRH secretion in women [Abstract]. In: Program of the 72nd annual meeting of The Endocrine Society, Atlanta, GA, 1990: 350.Google Scholar
- 8.Hall JE. The midcycle surge: quantity of GnRH secretion in the human, estimated by susceptibility to GnRH antagonism [Abstract]. In: Program of the 73rd annual meeting of The Endocrine Society, Washington, DC, 1991.Google Scholar
- 9.Hall JE, Taylor AE, Martin KA, Crowley WF Jr. Response of patients with polycystic ovarian disease to GnRH antagonist administration [Abstract]. Clin Res 1990; 38: 342A.Google Scholar
- 11.Filicori M, Butler JP, Crowley WF. Neuroendocrine regulation of the corpus luteum in the human. J Clin Endocrinol Metab 1984; 73: 1638–47.Google Scholar
- 15.Whitcomb RW, O’Dea LSTL, Finkelstein JS, Heavern DM, Crowley WF Jr. Utility of free a-subunit as an alternative neuroendocrine marker of gonadotropin-releasing hormone (GnRH) stimulation of the gonadotroph in the human: evidence from normal and GnRH-deficient men. J Clin Endocrinol Metab 1990; 70: 1654–61.PubMedCrossRefGoogle Scholar
- 19.Clarke I. Exactitude in the relationship between GnRH and LH secretion. In: Crowley WF Jr, Conn PM, eds. Modes of action of GnRH and GnRH analogs. (See Chapter 11, this volume.)Google Scholar
- 20.Urban JH, Meredith JM, Bauer-Dantoin AC, Strobl FJ, Levine J. Gonadal feedback regulation of LHRH release and actions in the rat. In: Crowley WF Jr, Conn PM, eds. Modes of action of GnRH and GnRH analogs. (See Chapter 13, this volume.)Google Scholar
- 21.Caraty A, Bouchard P, Blane MR. Studies of LHRH secretion into the hypophyseal portal blood of the ram: gonadal regulation of LH secretion is mainly exerted at the hypothalamic level. In: Crowley WF Jr, Conn PM, eds. Modes of action of GnRH and GnRH analogs. (See Chapter 12, this volume.)Google Scholar
- 22.Karsch F, Moenter SM, Caraty A. The preovulatory surge of GnRH secretion: characterization and regulation. In: Crowley WF Jr, Conn PM, eds. Modes of action of GnRH and GnRH analogs. (See Chapter 15, this volume.)Google Scholar
- 25.Clayton RN, Solano AR, Garcia-Vela A, Dufau ML, Catt KJ. Regulation of pituitary receptors for gonadotropin-releasing hormone during the rat estrous cycle. Endocrinology 1980: 699–706.Google Scholar
- 28.Fraser HM, Abbott M, Laird NC, McNeilly AS, Nestor JJ Jr, Bickery BH. Effects of an LH-releasing hormone antagonist on the secretion of LH, FSH, prolactin and ovarian steroids at different stages of the luteal phase in the stumptailed macaque (Maraca arctoides). J Endocrinol 1986; 111: 83–90.PubMedCrossRefGoogle Scholar