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Gonadotropin Releasing Hormone and Its Actions

  • Conference paper
Modes of Action of GnRH and GnRH Analogs

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

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Abstract

Gonadotropin releasing hormone plays a central role in regulating the reproductive process. Since isolation of this decapeptide and identification of its structure almost twenty years ago, our understanding of the neural control of reproduction and neuroendocrinology as a whole has experienced tremendous growth. Analogs of GnRH are now being used clinically to treat precocious puberty in children, endometriosis, polycystic ovarian disease, and two of the most prevalent steroid-dependent neoplasia, prostate cancer and breast cancer. In addition, GnRH and its analogs have proven useful in enhancing the reproductive efficiency of animals produced for both food and fiber. Clearly, basic research into the physiology and pharmacology of GnRH can be regarded as particularly successful in light of the relatively short time-span from basic studies to practical utility. In addition to the direct clinical applications of GnRH, the study of this hormone has contributed to our understanding of the mechanisms and pattern of hormone release, as well as the mechanisms by which responsiveness of target glands are regulated. Therefore, studies on GnRH have spanned the many areas of physiology, pharmacology, endocrinology, reproductive biology, cellular biology, and molecular biology.

Adapted, with permission, from The Stevenson Lecture (Can J Physiol Pharmacol 1991). Supported by NIH Grant HD19899. Dr. Braden is supported by a Carver Fellowship of the University of Iowa College of Medicine.

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Authors
  1. Tim D. Braden
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  2. P. Michael Conn
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Editors and Affiliations

  1. Reproductive Endocrine Unit Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA

    William F. Crowley Jr. M.D.

  2. Department of Pharmacology, University of Iowa College of Medicine, Iowa City, IA, 52242-1109, USA

    P. Michael Conn Ph.D.

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© 1992 Springer-Verlag New York, Inc.

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Braden, T.D., Conn, P.M. (1992). Gonadotropin Releasing Hormone and Its Actions. In: Crowley, W.F., Conn, P.M. (eds) Modes of Action of GnRH and GnRH Analogs. Serono Symposia, USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2916-2_2

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  • DOI: https://doi.org/10.1007/978-1-4612-2916-2_2

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