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Gastrointestinal Aspects of Epidermolysis Bullosa

  • Gulchin Ergun
  • Robert A. Schaefer

Abstract

The gastrointestinal complications of epidermolysis bullosa (EB) are a major cause of symptoms and morbidity and contribute substantially to the nutritional problems and growth retardation of these patients. The most severe problems are related to involvement of the proximal gut, oropharynx, and esophagus. However, anal lesions and altered colonic function lead to frequent difficulties with bowel function. In one study of 101 EB patients representing simplex, junctional and dystrophic forms of EB,1 a wide variety of upper gastrointestinal symptoms were seen in 68 patients. These consisted of oral blisters, odynophagia, dysphagia, dental anomalies, microstomia and pyrosis. Forty six patients had lower gastrointestinal manifestations, consisting of hematochezia, anal pain, constipation, perianal blisters and tenesmus. Management of these gastrointestinal complications is difficult and must be approached cautiously because of the danger of further injury to the squamous mucosa.

Keywords

Epidermolysis Bullosa Esophageal Lesion Percutaneous Endoscopic Gastrostomy Placement Anal Lesion Dystrophic Epidermolysis Bullosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Gulchin Ergun
  • Robert A. Schaefer

There are no affiliations available

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