Calcium-Diacetyl-Homotaurinate which Pre-Vents Relapse in Weaned Alcoholics Decreases the Action of Excitatory Amino Acids in Neo-Cortical Neurons of the Rat in Vitro
The behavioural disorder of compulsive drinking and the severe medical and social consequences urge research to find effective prevention and intervention strategies. The acute and chronic action of ethanol have been studied with quite a variety of techniques, but the mechanism(s) of action still remain an unresolved puzzle. Although we do not have any unifying hypothesis about the action of ethanol on synaptic transmission, there is growing evidence that in addition to biogenic amines (see Naranjo et al. this meeting), neuropeptides and steroids (2), amino acids like L-glutamate (L-GLU) (8) and y-amino butyric acid (GABA) (1) are involved in the acute and chronic action of ethanol. In particular, a subtype of the excitatory amino acid neurotransmitter (EAA), the N-methyl-D-aspartate (NMDA) receptor, has gained considerable attention in recent alcohol research. A synopsis of the available evidence sug¬gests that NMDA receptor mediated responses may be primary targets for acute and chronic alcohol action (8). This receptor subtype appears to play important roles in learning and memory, developmental plasticity, epilepsy and various neurodegenerative disorders. L-homocysteic acid (L-HCA) is a putative endogenous ligand (besides L-GLU) for the NMDA receptor in central neurons (13; 17).
KeywordsNMDA Receptor Excitatory Amino Acid Rest Membrane Potential Neocortical Neuron Excitatory Amino Acid Receptor
Unable to display preview. Download preview PDF.
- 3.Boismare, F., Daoust M., Lhuintre J.P., Moore N., Saliguat, C. and Flipo J.L. Alcohol and Alcoholism 21: A30, 1986.Google Scholar
- 6.Daoust, M., Lhuintre, J.P., Saligaut, C., Chretien, P., Moore, N. and F. Boismare. J.Pharmacol 16: 521–529 (1985).Google Scholar
- 17.Zeise, M.L., Knöpfel, Th., Cuenod, M., and W. Zieglgänsberger. In: E.A. Cavalheiro et al. (eds.) Frontiers in Excitatory Amino Acid Research. New York: Alan R. Liss, 1988 (pp. 187–192 ).Google Scholar
- 18.Zeise, M.L., Kasparow, S., Capogna, M., and W. Zieglgänsberger. In: H. Pasantes-Morales et al.(eds.) Taurine: Functional Neurochemistry, Physiology, and Cardiology. New York: Wiley-Liss Inc. 1990 (pp. 237–242 ).Google Scholar