Skip to main content

Eye Movements and the Zonal Structure of the Rabbit Flocculus

  • Chapter
The Cerebellum Revisited

Abstract

The flocculus is part of the compensatory eye movement control system that can stabilize gaze during head rotations about any axis in space. Therefore, understanding signal processing in the flocculus requires knowledge of how the multi-dimensionality of these eye movements is represented. Studies of the messages carried by the visual climbing fibers (CFs) as well as studies of the eye movements and eye muscle activity elicited by electrical stimulation suggest that the basis of this representation is the zonal structure of the flocculus.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Andersson, G., and Oscarsson, O. (1978a): Projections to lateral vestibular nucleus from cerebellar climbing fiber zones. Exp. Brain Res., 32, 549–564.

    PubMed  CAS  Google Scholar 

  • Andersson, G., and Oscarsson, O. (1978b): Climbing fiber microzones in cerebellar vermis and their projection to different groups of cells in the lateral vestibular nucleus. Exp. Brain Res., 32, 565–579.

    PubMed  CAS  Google Scholar 

  • Baker, R.G., Precht, W, Llinás, R. (1972): Cerebellar modulatory action on the vestibulo-trochlear pathway in the cat. Exp. Brain Res., 15, 364–385.

    Article  PubMed  CAS  Google Scholar 

  • Brodal, A., and Kawamura, K. (1980): Olivocerebellar projection: A review. Adv. Anat. Embryol. Cell Biol., 64, 1–140.

    Article  Google Scholar 

  • Collewijn, H. (1977): Eye- and head-movements in freely moving rabbits. J. Physiol. (Lond.), 266, 471–498.

    CAS  Google Scholar 

  • Dufossé, M., Ito, M., and Miyashita, Y. (1977): Functional localization in the rabbitx2019;s cerebellar flocculus determined in relationship with eye movements. Neurosci. Lett., 5, 273–277.

    Article  PubMed  Google Scholar 

  • Ezure, K., and Graf, W. (1984): A quantitative analysis of the spatial organization of the vestibulo-ocular reflexes in lateral and frontal eyed animals. I. Orientation of semicircular canals and extraocular muscles. Neuroscience, 12, 85–93.

    CAS  Google Scholar 

  • Fukuda, J., Highstein, S.M., and Ito, M. (1972): Cerebellar inhibitory control of the vestibulo-ocular reflex investigated in rabbit Illrd nucleus. Exp. Brain Res., 14,511–526.

    Article  PubMed  CAS  Google Scholar 

  • Gerrits, N.M., and Voogd, J. (1982): The climbing fiber projection to the flocculus and adjacent paraflocculus in the cat. Neuroscience, 7, 2971–2991.

    Article  PubMed  CAS  Google Scholar 

  • Graf, W., and Simpson, J.I. (1981): The relations between the semicircular canals, the optic axis, and the extraocular muscles in lateral-eyed and frontal-eyed animals. In: Progress in Oculomotor Research Dev. Neurosci. (A. Fuchs, and W. Becker, eds). Amsterdam: Elsevier, pp. 411–420.

    Google Scholar 

  • Graf, W., Simpson, J.I., and Leonard, C.S. (1988): The spatial organization of visual messages in the flocculus of the rabbit’s cerebellum. II. Complex and simple spike responses of Purkinje cells. J. Neurophysiol., 60, 2091–2121.

    CAS  Google Scholar 

  • Groenewegen, H.J., and Voogd, J. (1977): The parasagittal zonation within the olivocerebellar projection. I. Climbing fiber distribution to the vermis of cat cerebellum. J. Comp. Neurol., 174, 417–488.

    CAS  Google Scholar 

  • Hess, D.T., and Voogd, J. (1986): Chemoarchitectonic organization of the monkey cerebellum. Brain Res., 369, 383–387.

    Article  PubMed  CAS  Google Scholar 

  • Highstein, S.M. (1973): Synaptic linkage in the vestibulo-ocular and cerebello-vestibular pathways to the Vlth nucleus in the rabbit. Exp. Brain Res., 17, 301–314.

    PubMed  CAS  Google Scholar 

  • Ito, M., Highstein, S.M., and Fukuda, J. (1970): Cerebellar inhibition of the vestibulo-ocular reflex in rabbit and cat and its blockage by picrotoxin. Brain Res., 17, 524–526.

    Article  PubMed  CAS  Google Scholar 

  • Ito M., Nisimaru, N., Yamamoto, M. (1973): Specific neural connections for the cerebellar control of vestibulo-ocular reflexes. Brain Res., 60, 238–243.

    Article  PubMed  CAS  Google Scholar 

  • Ito, M., Nisimaru, N., and Yamamoto, M. (1977): Specific patterns of neuronal connetions involved in the control of rabbit’s vestibulo-ocular reflexes by the cerebellar flocculus. J. Physiol. (Lond., 265, 833–854.

    CAS  Google Scholar 

  • Ito, M., Orlov, I., and Yamamoto, M. (1982): Topographical representation of vestibulo-ocular reflexes in rabbit cerebellar flocculus. Neuroscience, 7, 1657–1664.

    Article  PubMed  CAS  Google Scholar 

  • Kawaguchi, Y. (1985): Two groups of secondary vestibular neurons mediating horizontal canal signals, probably to the ipsilateral medial rectus muscle, under inhibitory influences from the cerebellar flocculus in rabbit. Neurosci. Res., 2, 434–446.

    Article  PubMed  CAS  Google Scholar 

  • Leonard, C.S. (1986): Signal characteristics of cerebellar Purkinje cells in the rabbit flocculus during compensatory eye movements. Doctoral dissertation, New York University.

    Google Scholar 

  • Leonard, C.S., Simpson, J.I., and Graf, W. (1988): The spatial organization of visual messages in the flocculus of the rabbix2019;s cerebellum. I. Typology of inferior olive neurons of the dorsal cap of Kooy. J. Neurophysiol., 60, 2073–2090.

    CAS  Google Scholar 

  • Nagao, S., Ito, M, Karachot, L. (1985): Eye field in the cerebellar flocculus of pigmented rabbits determined with local electrical stimulation. Neurosci. Res., 3, 39–51.

    Article  PubMed  CAS  Google Scholar 

  • Oscarsson, O. (1969): The sagittal organization of the cerebellar anterior lobe as revealed by the projection patterns of the climbing fiber system. In: Neurobiology of Cerebellar Evolution and Development (R. Llinás, ed.). Chicago, IL: American Medical Association, pp. 525–537.

    Google Scholar 

  • Oscarsson, O. (1979): Functional units of the cerebellum—sagittal zones and microzones. Trends Neurosci., 2, 143–145.

    Article  Google Scholar 

  • Oscarsson, O., and Sjölund, B. (1977): The ventrospino-cerebellar system in the cat. I. Identification of five paths and their termination in the cerebellar anterior lobe. Exp. Brain Res., 28,469–486.

    CAS  Google Scholar 

  • Robinson, D.A. (1963): A method of measuring eye movement using a scleral search coil in a magnetic field. IEEE Trans. Biomed. Electron., 10, 137–145.

    CAS  Google Scholar 

  • Simpson, J.I. (1983): Transformation of coordinates intrinsic to the vestibulo-ocular reflex. Soc. Neurosci. Abstr., 9,315.

    Google Scholar 

  • Simpson, J.I., and Alley, K.E. (1974): Visual climbing fiber input to rabbit vestibulo-cerebellum: a source of direction-specific information. Brain Res., 82, 302–308.

    Article  PubMed  CAS  Google Scholar 

  • Simpson, J.I., and Graf, W. (1981): Eye muscle geometry and compensatory eye movements in lateral-eyed and frontal-eyed animals. Ann. NY Acad Set, 374, 20–30.

    Article  CAS  Google Scholar 

  • Simpson, J.I., and Graf, W. (1985): The selection of reference frames by nature and its investigators. In: Adaptive Mechanisms in Gaze Control (A. Bethoz, and M.G. Jones, eds). Amsterdam: Elsevier, pp. 3–16.

    Google Scholar 

  • Simpson, J.I., Graf, W., and Leonard, C. (1981): The coordinate system of visual climbing fibers to the flocculus. In: Progress in Oculomotor Research, Developments in Neuroscience (A. Fuchs, and W. Becker, eds). Amsterdam: Elsevier, pp. 475–484.

    Google Scholar 

  • Simpson, J.I., and Hess, R. (1977): Complex and simple visual messages in the flocculus. In: Control of Gaze by Brain Stem Neurons (R. Baker, and A. Berthoz, eds). Amsterdam: Elsevier/North Holland, pp. 351–360.

    Google Scholar 

  • Simpson, J.I., Soodak, R.E., and Hess, R. (1979): The accessory optic system and its relation to the vestibulocerebellum. In: Reflex Control of Posture and Movement (R. Granit, and O. Pompeiano eds). Amsterdam: Elsevier, pp. 715–725.

    Chapter  Google Scholar 

  • Tan, J., Eisenman, L.M., Gerrits, N.M., Hawkes, R., and Voogd, J. (1989): Compartmentalization within the rabbit flocculus. A mabQ 113 immunohisto-chemical, acetylcholinesterase and anatomical tracing study. Eur. J. Neurosci., 2, (Suppl) 33.

    Google Scholar 

  • Van der Steen, J., and Collewijn, H. (1984): Ocular stability in the horizontal, frontal and sagittal planes in the rabbit. Exp. Brain Res., 56, 263–274.

    Article  PubMed  Google Scholar 

  • Van der Steen, J., Simpson, J.I., and Tan, J. (1989): Eye movements evoked from histochemically distinguished compartments of the rabbit flocculus. Soc. Neurosci. Abstr., 15, 613.

    Google Scholar 

  • Voogd, J. (1969): The importance of fiber connections in the comparative anatomy of the mammalian cerebellum. In: Neurobiology of Cerebellar Evolution and Development (R. Llinás, ed.). Chicago, IL: American Medical Association, pp. 493–514.

    Google Scholar 

  • Voogd, J., and Bigaré, F. (1980): Topographical distribution of olivary and cortico nuclear fibers in the cerebellum: A review. In: The Inferior Olivary Nucleus (J. Courville, C. De Montigny, and Y. LaMarre eds). New York: Raven Press, pp. 207–234.

    Google Scholar 

  • Voogd, J., Gerrits, N.M., and Hess, D.T. (1987): Parasagittal zonation of the cerebellum in macaques: An analysis based on acetylcholinesterase histochemistry. In: Cerebellum and Neuronal Plasticity (M. Glickstein, C. Yeo, and J. Stein, eds). New York: Plenum, pp. 15–39.

    Chapter  Google Scholar 

  • Yamamoto, M. (1979): Vestibulo-ocular reflex pathways of rabbits and their representation in the cerebellar flocculus. In: Progress in Brain Research. Reflex Control of Posture and Movement (R. Granit, and O. Pompeiano, eds). Amsterdam: Elsevier/ North Holland, pp. 451–457.

    Chapter  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Simpson, J.I., Van der Steen, J., Tan, J. (1992). Eye Movements and the Zonal Structure of the Rabbit Flocculus. In: Llinás, R., Sotelo, C. (eds) The Cerebellum Revisited. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2840-0_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-2840-0_13

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7691-3

  • Online ISBN: 978-1-4612-2840-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics