Spinal Cord Atrophy

  • Robert N. N. Holtzman
  • Wen C. Yang
Part of the Contemporary Perspectives in Neurosurgery book series (COPENEU)


Spinal cord atrophy represents an irreversible state of degeneration manifested both radiographically and pathologically by a loss of spinal cord substance. It is accompanied by varying clinical states of myeloradiculopathy and is slowly progressive without remissions. There is as yet no significant surgical or medical therapy capable of reversing this process once it has begun. There remains some possibility that a plateau may be reached in the evolution of neurological symptoms by early decompression in instances of mechanical deformation of the spinal cord, and perhaps also by excision lesions capable of producing ischemic disturbances such as intramedullary vascular tumors and arteriovenous malformations.


Spinal Cord Cervical Spinal Cord Cervical Spondylosis Spastic Paraparesis Sagittal Diameter 
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  1. 1.
    Reeves CE. Diseases of the Spinal Cord and its Membranes. London: Simkin, Marshall & Co;1858:224–228.Google Scholar
  2. 2.
    Nordqvist L. The sagittal diameter of the spinal cord and subarachnoid space in different age groups-A roentgenographic postmortem study. Acta Radiol. 1964; 227 (Suppl): 1–96.Google Scholar
  3. 3.
    Drachman DB, Banker BW. Arthrogryposis multiplex congenita. Arch Neurol. 1961; 511: 89–105.Google Scholar
  4. 4.
    Gibson DA. Arthrogryposis multiplex congenita. In: Vinken PJ, Bruyn GW, eds. Handbook of Neurology. Amsterdam: Elsevier/North-Holland Biomedica Press; 1978: 511–518.Google Scholar
  5. 5.
    Staal A, Stefanko SZ, Busch HF, Jennekens FG, DeBruin JWC. Autonomic nerve calcification and peripheral neuropathy in olivopontocerebellar atrophy. J Neurol Sci. 1981; 51 (3): 383–394.PubMedCrossRefGoogle Scholar
  6. 6.
    Boman K. Spinal cord atrophy in spastic paraplegia. Acta Neurol Scand. 1967; 43: 180–188.PubMedCrossRefGoogle Scholar
  7. 7.
    Shirare T, Indue N, Wakisaka S, Yoshida H, Hoshiko M. Case of multiple sclerosis with repeated exacerbations of transverse myelopathy at a single level and severe atrophy of the spinal cord found at autopsy. Brain-Nerve(Tokyo). 1971;23(12):1575–1581.Google Scholar
  8. 8.
    Cloys DE, Netsky MG. Neuromyelitis optica. In: Vinken PJ, Bruyn GW, eds. Handbook of Neurology. Amsterdam: North-Holland Publishing Co; 1970: 452–468.Google Scholar
  9. 9.
    Folliss AGH, Netsky MG. Progressive necrotic myelopathy. In: Vinken PJ, Bruyn GW, eds. Handbook of Neurology. Amsterdam: North-Holland Publishing Co; 1970: 452–468.Google Scholar
  10. 10.
    Hughes JT, Brownell B. Paraplegia following retrograde abdominal aortography. Arch Neurol. 1965; 12: 650–659.PubMedGoogle Scholar
  11. 11.
    Schiller F. Venery, the spinal cord and tabes dorsalis before Romberg: The contribution of Ernst Horn. J Nery Ment Dis. 1976; 163 (1): 1–9.CrossRefGoogle Scholar
  12. 12.
    Donaldson I, Gibson R. Spinal cord atrophy associated with arachnoiditis as demonstrated by computed tomography. Neuroradiology. 1982; 24: 101–105.PubMedCrossRefGoogle Scholar
  13. 13.
    Nakada T, Kwee IL, Palmaz JC. Computed tomography of spinal cord atrophy. Neuroradiology. 1982; 24: 97–99.PubMedCrossRefGoogle Scholar
  14. 14.
    Solomon RA, Stein BM. Unusual spinal cord enlargement related to intramedullary hemangioblastoma. J Neurosurg. 1988; 68: 550–553.PubMedCrossRefGoogle Scholar
  15. 15.
    McCormick PC, Stein BM. Intramedullary tumors in adults. Neurosurg Clin North Am.1990; 1 (3): 625.Google Scholar
  16. 16.
    Schliep G. Syringomyelia and syringobulbia. In: Vinken PJ, Bruyn GW, eds. Handbook of Neurology. Amsterdam: Elsevier/North-Holland Biomedical Press; 1978: 255–327.Google Scholar
  17. 17.
    Komaki S. Localized spinal cord atrophy: significance of its demonstration. Radiology. 1976; 121: 11–114.Google Scholar
  18. 18.
    Jellinger K. Neuropathology of cord injuries. In: Vinken PJ, Bruyn GW, eds. Handbook of Neurology. Amsterdam: North-Holland Publishing Co; 1976: 43–121.Google Scholar
  19. 19.
    Panse F. Electrical trauma. In: Vinken PJ, Bruyn GW, eds. Handbook of Neurology. Amsterdam: North-Holland Publishing Co; 1975: 683–729.Google Scholar
  20. 20.
    Siebert CE, Barnes JE, Dreisbach JN, Swanson WB, Heck RJ. Accurate CT measurement of the spinal cord using metrizamide: Physical factors. Am J Roentgenol. 1980; 136: 777–780.Google Scholar
  21. 21.
    Koehler PR, Anderson RE, Baxter B. The effect of computed tomography viewer controls on anatomical measurements. Radiology. 1979; 130: 189–194.PubMedGoogle Scholar
  22. 22.
    Yousem DM, Janick PA, Atlas SW, et al. Pseudoatrophy of the cervical portion of the spinal cord on MR images: A manifestation of the truncation artifact. AJNR. 1990; 11: 373–377.PubMedGoogle Scholar
  23. 23.
    Curtin AJ, Chakeres DW, Bulas R, Boesel CP, Finneran M, Flint E. MR imaging artifacts of the axial internal anatomy of the cervical spinal cord. AJNR. 1989; 10: 19–26.Google Scholar
  24. 24.
    Thijssen HOM, Keyser A, Horstink MWM, Meijer E. Morphology of the cervical spinal cord on computed myelography. Neuroradiology. 1979; 18: 57–62.PubMedCrossRefGoogle Scholar
  25. 25.
    Gellad F, Krishna CVGR, Joseph PM, Vigorito RD. Morphology and dimensions of the thoracic cord by computer-assisted metrizamide myelography. AJNR. 1983; 4: 614–617.PubMedGoogle Scholar
  26. 26.
    Braun IF, Raghavendra BN, Kricheff II. Spinal cord imaging using real-time high-resolution ultrasound. Radiology. 1983; 147: 459–465.PubMedGoogle Scholar
  27. 27.
    Mawad ME, Hilal SK, Fetell MR, Silver AJ, Ganti SR, Sane P. Patterns of spinal cord atrophy by metrizamide CT. AJNR. 1983; 4: 611–613.PubMedGoogle Scholar
  28. 28.
    Critchley M. Neurology of old age. Lancet. May 23, 1931: 1125–1126.Google Scholar
  29. 29.
    Holtzman RNN, Hughes JEO, Sachdev RK, Jarenwattananon A. Intramedullary cysticercosis. Surg Neurol. 1986; 26: 187–191.PubMedCrossRefGoogle Scholar
  30. 30.
    Breig A, Turnbull J, Hassler O. Effects of mechanical stress on the spinal cord in cervical spondylosis. J Neurosurg. 1966; 25: 45–56.PubMedCrossRefGoogle Scholar

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© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Robert N. N. Holtzman
  • Wen C. Yang

There are no affiliations available

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