Abstract
A significant proportion of monoclonal antibodies developed against specific ovine (54%) and bovine (16.2%) leukocyte subpopulations cross-react with populations of cells from deer. These monoclonals have been of use to identify subpopulations of leukocytes within the cervine immune system and to characterize homologous monoclonal antibodies that have been developed against cervine peripheral blood leukocytes. Antibodies to ovine and bovine cells have also been found to cross-react with a variety of exotic ruminants including Pere David’s deer (Elaphurus davidianus). Poor levels of cross-reactivity were seen between human or mouse specific monoclonal antibodies and the ruminants tested in this study. The fact that some leukocyte markers are conserved between ruminants offers researchers the chance to use reagents produced against domesticated ruminants to characterize exotic species.
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© 1992 Springer-Verlag New York, Inc.
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Buchan, G., McCoy, G., Mackintosh, C.G., Frank, J. (1992). Monoclonal Antibodies to Leukocyte Subpopulations in Deer and Exotic Ruminants. In: Brown, R.D. (eds) The Biology of Deer. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2782-3_34
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DOI: https://doi.org/10.1007/978-1-4612-2782-3_34
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