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Antibodies to the Circumsporozoite Protein and Protective Immunity to Malaria Sporozoites

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Progress in Clinical Parasitology

Abstract

Malaria is caused by members of the genus Plasmodium. The four species infecting humans are Plasmodium falciparum, P. vivax, P. malariae, and P. ovale. Plasmodium sporozoites develop in the salivary glands of female anopheline mosquitoes and are transmitted to humans during a blood meal. The sporozoites remain in the host’s circulation for a brief period before entering hepatocytes, where they develop for 5–16 days depending on the species. During this period they increase in number thousands of times. A uninucleate P. falciparum sporozoite, for example, can develop into a multinucleate liver schizont with as many as 30,000–50,000 uninucleate merozoites. The phase beginning with sporozoite entry into the blood and ending with merozoite invasion of erythrocytes is called the exoerythrocytic phase of the disease.

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Authors
  1. Trevor R. Jones
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  2. W. Ripley Ballou
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  3. Stephen L. Hoffman
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Editor information

Editors and Affiliations

  1. Division of Clinical Pathology, North Shore University Hospital, Cornell University Medical College, 300 Community Drive, Manhasset, NY, 11030, USA

    Tsieh Sun M.D. (Professor and Chief) (Professor and Chief)

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© 1993 Springer-Verlag New York, Inc.

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Jones, T.R., Ballou, W.R., Hoffman, S.L. (1993). Antibodies to the Circumsporozoite Protein and Protective Immunity to Malaria Sporozoites. In: Sun, T. (eds) Progress in Clinical Parasitology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2732-8_4

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  • DOI: https://doi.org/10.1007/978-1-4612-2732-8_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7646-3

  • Online ISBN: 978-1-4612-2732-8

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