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Autocrine/Paracrine Regulation of Decidual Prolactin Expression

  • Conference paper
Trophoblast Cells

Part of the book series: Serono Symposia, USA Norwell, Massachusetts ((SERONOSYMP))

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Abstract

For many years theprolactin (PRL) gene was thought to be expressed only in the pituitary. However, more recent studies indicate that the PRL gene is also expressed in human decidual cells that are present in the uterus during the luteal phase of the menstrual cycle and during pregnancy (1–3). The mature secreted form of decidual PRL is identical to that of pituitary PRL (4, 5), and both PRLs are synthesized and released in glycosylated and nonglycosylated forms (6). However, the physiological roles of decidual PRL appear to be different than those demonstrated for pituitary PRL, and the factors involved in the regulation of decidual PRL expression are, in large part, different from those involved in the regulation of pituitary PRL expression. The PRL gene has also been shown to be expressed in lymphocytes (7) and ovarian, (8) lacrimal (9), and brain tissues (10), but the physiological roles of PRL and the factors that regulate PRL expression in these cells and tissues are unclear.

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Authors
  1. Stuart Handwerger
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  2. Randall G. Richards
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  3. Susan E. Myers
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Kansas Medical Center, 66160, Kansas City, KS, USA

    Michael J. Soares Ph.D.

  2. Department of Biology, Sinsheimer Laboratories, University of California, 95064, Santa Cruz, CA, USA

    Frank Talamantes Ph.D.

  3. Division of Endocrinology, Children’s Hospital Medical Center, 45229, Cincinnati, OH, USA

    Stuart Handwerger M.D.

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© 1993 Springer-Verlag New York, Inc.

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Handwerger, S., Richards, R.G., Myers, S.E. (1993). Autocrine/Paracrine Regulation of Decidual Prolactin Expression. In: Soares, M.J., Talamantes, F., Handwerger, S. (eds) Trophoblast Cells. Serono Symposia, USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2718-2_9

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  • DOI: https://doi.org/10.1007/978-1-4612-2718-2_9

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7641-8

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