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Expression by Transgenic Mouse Placenta of a Human Placental Hormone, the β-Subunit of Human Chorionic Gonadotropin

  • Brian L. Strauss
  • Robin H. Pittman
  • John H. Nilson
  • Irving Boime
Conference paper
Part of the Serono Symposia, USA Norwell, Massachusetts book series (SERONOSYMP)

Abstract

Chorionic gonadotropin (CG) is a member of a family of glycoprotein hormones that includeslutropin (LH), follitropin, and thyrotropin. The 4 hormones are heterodimers with a common α-subunit and unique β-subunits. While follitropin, thyrotropin, and LH are synthesized in the pituitary, CG is produced by the placenta. The LHβ and hCGβ subunits are structurally and functionally very similar; they share more than 80% amino acid sequence identity. Although all mammals synthesize LH, CG is produced only by primates and the horse (1). The CGβ and LHβ subunit genes comprise a linked 7-member cluster; the 6 CGβ genes are thought to have arisen by gene duplication of an ancestral single LHR gene (1–4) (Fig. 18.1). The CGβ synthesis peaks in the first trimester and declines thereafter to barely detectable levels at term (5, 6). Most of steady state CGβ mRNA is transcribed from CGβ genes 5, 3, and 8; the relative levels of expression are β5 > β3 = β8 > β7, β1, β2 (4).

Keywords

Chorionic Gonadotropin Human Chorionic Gonadotropin Human Placenta Subunit Gene RNAse Protection Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  • Brian L. Strauss
  • Robin H. Pittman
  • John H. Nilson
  • Irving Boime

There are no affiliations available

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