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Genetic Abnormalities in the Human Preimplantation Embryo

  • Alan H. Handyside
Conference paper
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

In the human, gross genetic abnormalities, mainly involving chromosome number, are a major cause of pregnancy failure. The incidence of chromosomal abnormalities at birth in the normal population is about 0.5% (1). However, a high proportion of fetuses examined after induced or spontaneous abortions are karyotypically abnormal, with numerical chromosome anomalies indicating that the incidence at conception is much higher (2). The development of methods associated with in vitro fertilization (IVF) for the treatment of infertility over the last ten years has facilitated direct study of the incidence of genetic abnormalities in gametogenesis, at fertilization, and during preimplantation development.

Keywords

Duchenne Muscular Dystrophy Preimplantation Embryo Cystic Fibrosis Transmembrane Regulator Preimplantation Development Hypoxanthine Phospho Ribosyl Transferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc 1993

Authors and Affiliations

  • Alan H. Handyside

There are no affiliations available

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