Regulation of Human Cytotrophoblast Invasion

  • Kathryn E. Bass
  • Iris Roth
  • Caroline H. Damsky
  • Susan J. Fisher
Part of the Serono Symposia, USA book series (SERONOSYMP)


Human cytotrophoblast invasion of the uterus is the result of an unusual differentiation process in which polarized epithelial cells, anchored to the chorionic villus basement membrane, become detached, aggregate into multilayered columns of nonpolarized cells, and rapidly penetrate the endometrium, the first third of the myometrium, and the associated spiral arterioles (Fig. 12.1). This process continues through the first trimester, peaks during the 12th week of pregnancy, and declines rapidly thereafter (1–4). The result is formation of the hemochorial placenta in which the fetal trophoblast cells are constantly bathed by maternal blood.


Human Placenta Uterine Wall Trophoblast Invasion Human Trophoblast Invasive Pathway 
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Copyright information

© Springer-Verlag New York, Inc 1993

Authors and Affiliations

  • Kathryn E. Bass
  • Iris Roth
  • Caroline H. Damsky
  • Susan J. Fisher

There are no affiliations available

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