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Abstract

Embryo implantation in primates relies on endocrine mechanisms that are distinct from those in nonprimate species. In all primate species studied to date, the embryo enters the uterus as a morula on day 3–4 after ovulation, hatches from the zona pellucida on day 6–8 and attaches to the maternal endometrial epithelium on day 8–9 in Old World species (1,2); day 11–12 in the marmoset monkey (3, 4) and probably day 6 in the squirrel monkey (5). The morphology of implantation is now well described for a few primate species, including the rhesus monkey (1, 6), baboon (7), and marmoset (8, 9). Comparisons with human implantation still depend largely on the classic studies of Hertig and Rock (10).

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References

  1. Enders AC, Hendrickx AG, Schlafke S. Implantation in the rhesus monkey: initial penetration of the endometrium. Am J Anat 1983;167:275–298.

    Article  PubMed  CAS  Google Scholar 

  2. Lenton EA, Woodward AJ. The endocrinology of conception cycles and implantation in women. J Reprod Fertil 1988;36:1–15.

    CAS  Google Scholar 

  3. Hearn JP, Summers PM. Experimental manipulation of embryo implantation in the marmoset monkey and exotic equids. Theriogenology 1986;25:3–11.

    Article  Google Scholar 

  4. Hearn JP, Hodges JK, Gems S. Early secretion of chorionic gonadotrophin by marmoset embryos in vivo and in vitro. J Endocrinol 1988a;119:249–255.

    Article  PubMed  CAS  Google Scholar 

  5. Edwards RG. Current status of human conception in vitro. Proc R Soc Lond [Biol] 1985;B223:417–448.

    Article  Google Scholar 

  6. Enders AC, Lantz KC, Schlafke S. Differentiation of trophoblast of the baboon blastocyst. Anat Record 1989;225:329–340.

    Article  CAS  Google Scholar 

  7. Tarara R, Enders AC, Gulamhusein N, et al. Early implantation and embryonic development of the baboon: stage 5, 6 and 7. Anat Embryol 1987;175:117–126.

    Google Scholar 

  8. Moore HDM, Gems S, Hearn JP. Early implantation stages in the marmoset monkey (Callithrix jacchus). Am J Anat 1985;172:265–278.

    Article  PubMed  CAS  Google Scholar 

  9. Smith CA, Moore HDM, Hearn JP. The ultrastructure of early implantation in the marmoset monkey (Callithrix jacchus). Anat Embryol 1987; 175:399–410.

    Article  PubMed  CAS  Google Scholar 

  10. Hertig AT, Rock J. Two human ova of the pre-villous stage having a developmental age of about seven and nine days, respectively. Carnegie Contrib Embryol 1945;31:65–84.

    Google Scholar 

  11. Stewart HJ, Jones DSC, Pascall JC, Popkin RM, Flint APF. The contribution of recombinant DNA techniques of reproductive biology. J Reprod Fertil 1988;83:1–57.

    Article  PubMed  CAS  Google Scholar 

  12. Braude PR, Bolton V, Moore S. Human gene expression first occurs between the four- and eight-cell stages of preimplantation development. Nature 1988;332:459–461.

    Article  PubMed  CAS  Google Scholar 

  13. Lopata A, Summers PM, Hearn JP. Births following the transfer of cultured embryos obtained by in vitro fertilization in the marmoset monkey, Callithrix jacchus. Fertil Steril 1988;50:503–509.

    PubMed  CAS  Google Scholar 

  14. Hearn JP, Gidley-Baird AA, Hodges JK, Summers PM, Webley GE. Embryonic signals during the peri-implantation period in primates. J Reprod Fertil Suppl 1988b;36:49–58.

    PubMed  CAS  Google Scholar 

  15. Edwards RG. Current status of human conception in vitro. Proc R Soc Lond [Biol] 1985;B223:417–448.

    Article  Google Scholar 

  16. Ziegler TE, Savage A, Scheffler G, Snowdon CT. The endocrinology of puberty and reproductive functioning in female cotton-top tamarins (Saguinus oedipus) under varying social conditions. Biol Reprod 1987;37:618–627.

    Article  PubMed  CAS  Google Scholar 

  17. Hearn JP. The embryo-maternal dialogue during early pregnancy in primates. J Reprod Fertil 1986;76:809–819.

    Article  PubMed  CAS  Google Scholar 

  18. Tesarik J. Involvement of oocyte-coded message in cell differentiation control of early human embryos. Development 1989;105:317–322.

    PubMed  CAS  Google Scholar 

  19. Surani MA, Allen ND, Barton SC, et al. Developmental consequences of imprinting of parental chromosomes by DNA methylation. Philos Trans R Soc Lond [Biol] 1990;B326:313–3207.

    Article  Google Scholar 

  20. Flach G, Johnson MH, Braude PR, Taylor RAS, Bolton VN. The transition from maternal to embryonic control in the 2-cell mouse embryo. EMBO J 1982;1:681–686.

    PubMed  CAS  Google Scholar 

  21. Bolton VN, Oades PJ, Johnson MH. The relationship between cleavage, DNA replication and gene expression in the mouse 2-cell embryo. J Embryol Exp Morphol 1984;79:139–163.

    PubMed  CAS  Google Scholar 

  22. Manes C. The participation of the embryonic genome during early cleavage in the rabbit. Dev Biol 1973;32:453–459.

    Article  PubMed  CAS  Google Scholar 

  23. Crosby IM, Gandolfi F, Moor RM. Control of protein synthesis during early cleavage of sheep embryos. J Reprod Fertil 1988;82:769–775.

    Article  PubMed  CAS  Google Scholar 

  24. Frei RE, Schultz GA, Church RB. Qualitative and quantitative changes in protein synthesis occur at the 8–16 cell stage of embryogenesis in the cow. J Reprod Fertil 1989;86:637–641.

    Article  PubMed  CAS  Google Scholar 

  25. Bonduelle M-L, Dodd R, Liebaers I, Van Steirteghem A, Williamson R, Akhurst R. Chorionic gonadotrophin-ß mRNA, a trophoblast marker, is expressed in human 8-cell embryos derived from tripronucleate zygotes. Hum Reprod 1988;3:909–914.

    PubMed  CAS  Google Scholar 

  26. Hearn JP, Webley GE, Gidley-Baird AA. Chorionic gonadotrophin and embryo-maternal recognition during the peri-implantation period in primates. J Reprod Fertil 1991;92:497–509.

    Article  PubMed  CAS  Google Scholar 

  27. Reyes FI, Winter JSD, Faiman C, Hobson WC. Serial serum levels of gonadotropins, prolactin and sex steroids in the non pregnant and pregnant chimpanzee. Endocrinology 1975;96:1447–1455.

    Article  PubMed  CAS  Google Scholar 

  28. Shaikh AA. Animal models for research in human reproduction. NIH Invited Report, Washington, DC, 1978.

    Google Scholar 

  29. Atkinson LE, Hotchkiss J, Fritz GR, Surve AH, Neill JD, Knobil E. Circulating levels of steroids and chorionic gonadotropin during pregnancy in the rhesus monkey, with special attention to the rescue of the corpus luteum in early pregnancy. Biol Reprod 1975;12:335–345.

    Article  PubMed  CAS  Google Scholar 

  30. Hearn JP, ed. Reproduction in New World primates. Lancaster, UK: MTP Press, 1983.

    Google Scholar 

  31. Chambers PL, Hearn JP. Embryonic, foetal and placental development in the common marmoset monkey (Callithrix jacchus). J Zool Lond 1985;A207:545–561.

    Google Scholar 

  32. Short RV. When a conception fails to become a pregnancy. In: Maternal recognition of pregnancy. Ciba Foundation Symposium 64. Amsterdam: Excerpta Medica, 1979:337–395.

    Google Scholar 

  33. Marston JH, Penn R, Sivelle PC. Successful autotransfer of tubal eggs in the rhesus monkey, Macaca mulatta. J Reprod Fertil 1977;49:175–176.

    Article  PubMed  CAS  Google Scholar 

  34. Summers PM, Shephard AM, Taylor CT, Hearn JP. The effects of cryopreservation and transfer on embryonic development in the common marmoset monkey, Callithrix jacchus. J Reprod Fertil 1987;79:241–250.

    Article  PubMed  CAS  Google Scholar 

  35. Lenton EA, Hooper M, King H, et al. Normal and abnormal implantation in spontaneous in-vivo and in-vitro human pregnancies. J Reprod Fertil 1991;92(2):555–565.

    Article  PubMed  CAS  Google Scholar 

  36. Summers PM, Taylor CT, Miller MW. Inner cell mass is required for efficient chorionic gonadotrophin secretion by common marmoset blastocysts. J Reprod Fertil 1992.

    Google Scholar 

  37. Lopata A, Hay DL. The potential of early human embryos to form blastocysts, hatch from their zona and secrete HCG in culture. Hum Reprod 1989;4(suppl):87–94.

    PubMed  CAS  Google Scholar 

  38. Lopata A, Oliva K. Regulation of chorionic gonadotropin secretion by cultured human blastocysts. In: Bavister BD, ed. Preimplantation embryo development. New York: Springer-Verlag, 1993.

    Google Scholar 

  39. Dokras A, Sargent IL, Ross C, Gardner RL, Barlow DH. The human blastocyst: morphology and human chorionic gonadotrophin secretion in vitro. Hum Reprod 1991;6(8):1143–1151.

    PubMed  CAS  Google Scholar 

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© 1993 Springer-Verlag New York, Inc

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Hearn, J.P., Seshagiri, P.B., Webley, G.E. (1993). Physiology of Implantation in Primates. In: Wolf, D.P., Stouffer, R.L., Brenner, R.M. (eds) In Vitro Fertilization and Embryo Transfer in Primates. Serono Symposia, USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2716-8_10

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  • DOI: https://doi.org/10.1007/978-1-4612-2716-8_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7640-1

  • Online ISBN: 978-1-4612-2716-8

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