GnRH Neurons in an Interpretation of Kallmann’s Syndrome
Since virtually all neurons in the mammalian brain are born adjacent to the linings of the cerebral ventricles and migrate a small distance to their final functional positions, it was surprising that the neurons that control vertebrate reproduction, those expressing gonadotropin releasing hormone (GnRH and LHRH), do not follow that rule. Rapidly gathering information about the origin and migration of GnRH neurons has recently been reviewed (1), and this chapter briefly sets some of those facts against a background of ideas about Kallmann’s syndrome and about gene transfer into brain.
KeywordsOlfactory Epithelium Neural Cell Adhesion Molecule Migration Route GnRH Neuron Olfactory Placode
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