Role of Calcium in the Secretion of Atrial Natriuretic Peptide

  • Mary F. Walsh
Part of the Endocrinology and Metabolism book series (EAM, volume 6)


Atrial natriuretic peptide (ANP), a potent natriuretic, diuretic, and smooth muscle relaxant, is released from atrial cardiomyocytes in response to a variety of stimuli, such as atrial distension and tachycardia, and in response to various vasoconstrictors.1,2 Although ANP appears to be stored in secretory granules in the form of a pre-hormone and to be proteolytically cleaved only upon secretion,3 the functional morphology of these granules is analogous to that of other endocrine secretory tissues, which suggests that calcium may play a role in their release.4 Indeed, the heart possesses a number of complex mechanisms for regulating the concentration of intracellular calcium ([Ca]i). Most of them involve the release of Ca2+ from a large intracellular pool in the sarcoplasmic reticulum (SR), although extracellular calcium [Ca]0 may also play a role in contractile function.5,6


Atrial Natriuretic Peptide Atrial Natriuretic Factor Calmodulin Inhibitor Atrial Preparation Atrial Stretch 
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© Springer-Verlag New York, Inc. 1994

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  • Mary F. Walsh

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