Skip to main content
SpringerLink
Log in

Hormonal Modulation of Sodium Pump Activity: Identification of Second Messengers

  • Chapter
Ion Channels and Ion Pumps

Part of the book series: Endocrinology and Metabolism ((EAM,volume 6))

  • 116 Accesses

Abstract

The sodium pump actively transports ions of sodium and potassium across the plasma membrane of most animal cells using energy acquired from the hydrolysis of ATP. Electrochemical gradients of sodium and potassium are formed that initiate the subsequent diffusion of sodium and potassium, which helps establish the resting membrane potential. Under normal physiologic conditions three Na+ ions are expelled in exchange for two K+ ions, which produces a net charge movement that also contributes to the resting membrane potential. The sodium pump regulates cell volume and the sodium gradient itself subserves the secondary transport of other amino acids, sugars, calcium ions, and protons. In more general terms the sodium pump is the major mechanism responsible for the ability of the body to regulate levels of sodium and potassium. The energy spent in this capacity is a major source of heat production.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Skou JC. The identification of the sodium-pump as the membrane-bound Na+/K+-ATPase. Biochim Biophys Acta 1989; 1000:435–438.

    PubMed  CAS  Google Scholar 

  2. Jorgensen PL. Mechanism of the Na, K-pump. Biochim Biophys Acta 1982; 694:26–68.

    Google Scholar 

  3. Pedemonte CH, Kaplan JH. Chemical modification as an approach to elucidation of sodium pump structure-function relations. Am J Physiol 1990; 258:C1–C23.

    PubMed  CAS  Google Scholar 

  4. Kawamura M, Naguchi S. Possible role of the ß-subunit in the expression of the sodium pump. In: Kaplan JH, DeWeer P, eds. The Sodium Pump: Structure, Mechanism, and Regulation. New York: Rockefeller University Press; 1991:45–61.

    Google Scholar 

  5. Sweadner KJ. Isozymes of the Na+/K+-ATPase. Biochim Biophys Acta 1989; 988:185–220.

    PubMed  CAS  Google Scholar 

  6. Lingrel JB, Orlowski J, Price EM, Pathak BG. Regulation of the a-subunit genes of the Na, K-ATPase and determinants of cardiac glycoside sensitivity. In: Kaplan JH, DeWeer P, eds. The Sodium Pump: Structure, Mechanism, and Regulation. New York: Rockefeller University Press; 1991:1–16.

    Google Scholar 

  7. Sweadner KJ. Overview: Subunit diversity in the Na, K-ATPase. In: Kaplan JH, DeWeer P, eds. The Sodium Pump: Structure, Mechanism, and Regulation. New York: Rockefeller University Press; 1991:63–76.

    Google Scholar 

  8. Omatsu-Kanbe M, Kitasato H. Insulin stimulates the translocation of Na+/ K+-dependent ATPase molecules from intracellular stores in the plasma membrane in frog skeletal muscle. Biochem J 1990; 272:727–733.

    PubMed  CAS  Google Scholar 

  9. Rossier BC, Geering K, Kraehenbuhl JP. Regulation of the sodium pump: How and why? TIBS 1987; 12:483–487.

    CAS  Google Scholar 

  10. Fambrough DM, Wolitzky BA, Taormino JP, Tamkun MM, Takeyasu K, Somerville D, Renaud KJ, Lemas MV, Lebovitz RM, Kone BC, Hamrick M, Rome J, Inman EM, Barnstein A. A cell biologists perspective on sites of Na, K-ATPase regulation. In: Kaplan JH, DeWeer P, eds. The Sodium Pump: Structure Mechanism, and Regulation. New York: Rockefeller University Press; 1991:17–30.

    Google Scholar 

  11. Giek GG, Ismail-Beigi F, Edelman IS. Hormonal regulation of Na, K-ATPase. Prog Clin Biol Res 1988; 268B:277–295.

    Google Scholar 

  12. Hernandez-R J. Na+/K+-ATPase regulation by neurotransmitters. Neurochem Int 1992; 20:1–10.

    Article  PubMed  CAS  Google Scholar 

  13. Vizi ES, Oberfrank F. Na+/K+-ATPase, its endogenous ligands and neurotransmitter release. Neurochem Int 1992; 20:11–17.

    Article  PubMed  CAS  Google Scholar 

  14. Brodsky JL. Characterization of the (Na+ + K+)-ATPase from 3T3–F442A fibroblasts and adipocytes: Isozymes and insulin sensitivity. J Biol Chem 1990; 265:10458–10465.

    PubMed  CAS  Google Scholar 

  15. McGill DL, Guidotti G. Insulin stimulates both the alpha 1 and the alpha 2 isoforms of the rat adipocyte (Na+, K+) ATPase. Two mechanisms of stimulation. J Biol Chem 1991; 266:15824–15831.

    PubMed  CAS  Google Scholar 

  16. Hajnoczky G, Csordas G, Hunyady L, Kalapos MP, Balla T, Enyedi P, Spat A. Angiotensin-II inhibits Na+/K+ pump in rat adrenal glomerulosa cells: Possible contribution to stimulation of aldosterone production. Endocrinology 1992; 130:1637–1644.

    Article  PubMed  CAS  Google Scholar 

  17. Clausen T, Everts ME. Regulation of the Na, K-pump in skeletal muscle. Kid Inter 1989; 35:1–13.

    Article  CAS  Google Scholar 

  18. Clausen T. Significance of Na+-K+ pump regulation in skeletal muscle. News Physiol Sei 1990; 5:148–151.

    Google Scholar 

  19. Aperia A, Fryckstedt J, Svensson L, Hemmings HC Jr, Nairn AC, Greengard P. Phosphorylated Mr 32,000 dopamine- and cAMP-regulated phosphoprotein inhibits Na+, K+-ATPase activity in renal tubule cells. Proc Natl Acad Sei USA 1991; 88:2798–2801.

    Article  CAS  Google Scholar 

  20. Bertorello AM, Hopfield JF, Aperia A, Greengard P. Inhibition by dopamine of (Na+, K+)-ATPase activity in neostriatal neurons through Dl and D2 dopamine receptor synergism. Nature 1990; 347:386–388.

    Article  PubMed  CAS  Google Scholar 

  21. Shah A, Cohen IS, Rosen MR. Stimulation of cardiac alpha receptors increases Na/K pump current and decreases gK via a pertussis toxin-sensitive pathway. Biophysic J 1988; 54:219–225.

    Article  CAS  Google Scholar 

  22. Sasaguri T, Watson SP. Phorbol esters inhibit smooth muscle contractions through activation of Na+-K+-ATPase. Br J Pharmacol 1990; 99:237–242.

    PubMed  CAS  Google Scholar 

  23. Schoner W. Endogenous digitalis-like factors. TIPS 1991; 12:209–211.

    Google Scholar 

  24. Phillis JW. Na+/K+-ATPase as an effector of synpatic transmission. Neurochem Int 1992; 20:19–22.

    Article  PubMed  CAS  Google Scholar 

  25. Shull GE, Greeb J, Lingrel JB. Molecular cloning of three distinct forms of the Na+, K+-ATPase a-subunit from rat brain. Biochemistry 1986; 25:8125–8132.

    Article  PubMed  CAS  Google Scholar 

  26. Lingham RB, Sen AK. Regulation of rat brain (Na+ + K+)-ATPase activity by cyclic AMP. Biochim Biophys Acta 1982; 688:475–485.

    Article  PubMed  CAS  Google Scholar 

  27. Delamere NA, Socci RR, King KL. Alteration of sodium, potassium-adenosine triphosphatase activity in rabbit ciliary processes by cyclic adenosine monophosphate-dependent protein kinase. Invest Ophth Vis Sei 1990; 31:2164–2170.

    CAS  Google Scholar 

  28. Marver DS, Lear S, Marver LT, Silva P, Epstein EH. Cyclic AMP-dependent stimulation of Na, K-ATPase in shark rectal gland. J Membr Biol 1986; 94:205–215.

    Article  PubMed  CAS  Google Scholar 

  29. Paris S, Rozengurt E. Cyclic AMP stimulation of Na, K pump activity in quiescent Swiss 3T3 cells. J Cell Physiol 1982; 112:273–280.

    Article  PubMed  CAS  Google Scholar 

  30. Ling L, Cantley L. The (Na, K)-ATPase of Friend erythroleukemia cells is phosphorylated near the ATP hydrolysis by an endogenous membrane-bound kinase. J Biol Chem 1984; 259:4089–4095.

    PubMed  CAS  Google Scholar 

  31. Skou JC. The influence of some cations on an adenosine triphosphatase from peripheral nerves. Biochim Biophys Acta 1957; 23:394–401.

    Article  PubMed  CAS  Google Scholar 

  32. Hoffman JF. Cation transport and structure of the red cell plasma membrane. Circulation 1962; 26:1201–1213.

    CAS  Google Scholar 

  33. Robinson JD. Nucleotide and divalent cation interactions with the (Na+ + K+)-dependent ATPase. Biochim Biophys Acta 1974; 341:232–247.

    PubMed  CAS  Google Scholar 

  34. Apell HJ, Marcus MM. (Na+ + K+)-ATPase in artificial lipid vesicles: Influence of the concentration of mono- and divalent cations on the pumping rate. Biochim Biophys Acta 1986; 862:254–264.

    Article  PubMed  CAS  Google Scholar 

  35. Tobin T, Akera T, Baskin I, Brody TM. Calcium ion and sodium- and potassium-dependent adenosine triphosphatase: Its mechanism of inhibition and identification of the ErP intermediate. Mol Pharmacol 1973; 9:336–349.

    PubMed  CAS  Google Scholar 

  36. Fukushima Y, Post RL. Binding of divalent cation to phosphoenzyme of sodium- and potassium-transport adenosine triphosphatase. J Biol Chem 1978; 253:6853–6862.

    PubMed  CAS  Google Scholar 

  37. Haag M, Gevers W, Böhmer RG. The interaction between calcium and the activation of the Na+, K+-ATPase by noradrenaline. Mol Cell Biochem 1985; 66:111–116.

    PubMed  CAS  Google Scholar 

  38. Vasallo PM, Post RL. Calcium ion as a probe of the monovalent cation center of sodium, potassium ATPase. J Biol Chem 1986; 261:16957–16962.

    PubMed  CAS  Google Scholar 

  39. Forbush B. Rapid release of 45Ca from an occluded state of the Na, K-pump. J Biol Chem 1988; 263:7970–7978.

    PubMed  CAS  Google Scholar 

  40. Winkler BS, Riley MV. Influence of calcium on retinal ATPases. Invest Ophth Vis Sei 1980; 19:562–564.

    CAS  Google Scholar 

  41. Yingst DR, Marcovitz MJ. Effect of hemolysate on calcium inhibition of the (Na+ + K+)-ATPase of human red blood cells. Biochem Biophys Res Commun 1983; lll(3):970–979.

    Article  Google Scholar 

  42. Yingst DR, Hoffman JF. Ca-induced K transport in resealed human red cells containing arsenazo III: Transmembrane effects of Na and K and the relationship to the functioning Na-K pump. J Gen Physiol 1984; 84:19–45.

    Article  Google Scholar 

  43. Turi A, Somogyi J, Muller N. The effect of micromolar Ca2+ on the activities of the different Na+/K+-ATPase isozymes in the rat myometrium. Biochem Biophys Res Commun 1991; 174:969–974.

    Article  PubMed  CAS  Google Scholar 

  44. Yingst DR. Modulation of the Na, K-ATPase by Ca and intracellular proteins. Annu Rev Physiol 1988; 50:291–303.

    Article  PubMed  CAS  Google Scholar 

  45. McGeoch JEM. The a2 isomer of the sodium pump is inhibited by calcium at physiological levels. Biochem Biophys Res Commun 1990; 173:99–105.

    Article  PubMed  CAS  Google Scholar 

  46. Aksentsev SL, Novitskaia NA, Okun’ IM, Lyskova TI, Konev SV. Membrane regulation of brain Na, K-ATPase inhibition by calcium ions. Biokhimiia 1980; 45:679–682.

    PubMed  CAS  Google Scholar 

  47. Turi A, Somogyi J. Possible regulation of the myometrial Na+/K+-ATPase activity by Ca2+ and cAMP-dependent protein kinase. Biochim Biophys Acta 1988; 940:77–84.

    Article  PubMed  CAS  Google Scholar 

  48. Komabayashi T, Izawa T, Suda K, Shinoda S, Tsuboi M. Effects of Ca2+ and calmodulin antagonists on the Na+ pump activity induced by pilocarpine in dog submandibular gland. Res Commun Chem Path Pharm 1987; 57:273–276.

    PubMed  CAS  Google Scholar 

  49. Vasilets LA, Schmalzing G, Madefessel K, Haase W, Schwarz W. Activation of protein kinase C by phorbol ester induces downregulation of the Na+/ K+-ATPase in oocytes of Xenopus laevis. J Membr Biol 1990; 118:131–142.

    Article  PubMed  CAS  Google Scholar 

  50. Lowndes JM, Hokin-Neaverson M, Bertics PJ. Kinetics of phosphorylation of Na+/K+-ATPase by protein kinase C. Biochim Biophys Acta 1990;1052:143–151.

    Article  PubMed  CAS  Google Scholar 

  51. Nishizuka Y. Studies and perspective of protein kinase C. Science 1986; 233:305–312.

    Article  PubMed  CAS  Google Scholar 

  52. Berridge MJ. Inositol trisphosphate and diacylglycerol: Two interacting second messengers. Ann Rev Biochem 1987; 56:159–193.

    Article  PubMed  CAS  Google Scholar 

  53. Oishi K, Zheng B, Kuo JF. Inhibition of Na, K-ATPase and sodium pump by protein kinase C regulators sphingosine, lysophosphatidylcholine, and oleic acid. J Biol Chem 1990; 265:70–75.

    PubMed  CAS  Google Scholar 

  54. Nishikawa T, Tomori Y, Yamashita S, Shimizu S. Inhibition of Na+, K+-ATPase activity by phospholipase A2 and several lysophospholipids: Possible role of phospholipase A2 in noradrenaline release from cerebral cortical synaptosomes. J Pharm Pharmacol 1989; 41:450–458.

    Article  PubMed  CAS  Google Scholar 

  55. Askari A, Xie ZJ, Wang YH, Periyasamy S, Huang WH. A second messenger role for monoacylglycerols is suggested by their activating effects on the sodium pump. Biochim Biophys Acta 1991; 1069:127–130.

    Article  PubMed  CAS  Google Scholar 

  56. Kim J, Rushovich EH, Thomas TP, Ueda T, Agranoff BW, Greene DA. Diminished specific activity of cytosolic protein kinase C in sciatic nerve of streptozocin-induced diabetic rats and its correction by dietary myoinositol. Diabetes 1991; 40:1545–1554.

    Article  PubMed  CAS  Google Scholar 

  57. Kowluru R, Bitensky MW, Kowluru A, Dembo M, Keaton PA, Buican T. Reversible sodium pump defect and swelling in the diabetic rat erythrocyte: Effects on filter ability and implications for microangiopathy. Proc Natl Acad Sei USA 1989; 86:3327–3331.

    Article  CAS  Google Scholar 

  58. Berthon B, Capiod T, Claret M. Effect of noradrenaline, vasopressin and angiotensin on the Na-K pump in rat isolated liver cells. Br J Pharmacol 1985; 86:151–161.

    PubMed  CAS  Google Scholar 

  59. Lynch CJ, Wilson RB, Blackmore PF, Exton JH. The hormone-sensitive hepatic Na+-pump: Evidence for regulation by diacylglycerol and tumor promoters. J Biol Chem 1985; 261:14551–14556.

    Google Scholar 

  60. Klee CB. Interaction of calmodulin with Ca2+ and target proteins. In: Cohen P, Klee CB, eds. Calmodulin. New York: Elsevier; 1988:35–56.

    Google Scholar 

  61. Cirillo M, David-Bufilho M, Devynck MA. Calmodulin reduces ouabain-sensitive ATPase of cardiac sarcolemmal membranes: High reduction in spontaneously hypertensive rats. Clin Sei 1984; 67:535–540.

    CAS  Google Scholar 

  62. David-Dufilho M, Cirillo M, Beugras JP, Meyer P, Devynck MA. Active calcium and sodium transport by cardiac plasma membranes in the genetically hypertensive rat [Fre]. Archives des Maladies du Coeur et des Vaisseaux 1984; 77:1261–1265.

    PubMed  CAS  Google Scholar 

  63. Yingst DR, Ye-Hu J, Chen H, Barrett V. Calmodulin increases Ca-dependent inhibition of the Na, K-ATPase in human red cells. Arch Biochem Biophys 1992; 295:49–54.

    Article  PubMed  CAS  Google Scholar 

  64. Huang WH, Askari A. Ca2+-dependent activities of (Na+ + K+)-ATPase. Arch Biochem Biophys 1982; 216:741–750.

    Article  PubMed  CAS  Google Scholar 

  65. Nelson WJ, Veshnock P. Ankyrin binding to (Na+ + K+)ATPase and implications for the organization of membrane domains in polarized cells. Nature 1987; 328:533–536.

    Article  PubMed  CAS  Google Scholar 

  66. Tokumitsu H, Chijiwa T, Hagiwara M, Mizutani A, Terasawa M, Hidaka H. KN-62, l-[N,0-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl-pip-erazine, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II. J Biol Chem 1990; 265:4315–4320.

    PubMed  CAS  Google Scholar 

  67. Albert KA, Wu C-S, Nairn AC, Greengard P. Inhibition by calmodulin of calcium/phospholipid-dependent protein phosphorylation. Proc Natl Acad Sei USA 1984; 81:3622–3625.

    Article  CAS  Google Scholar 

  68. Kruger H, Schroder W, Buchner K, Hucho F. Protein kinase C inhibition by calmodulin and its fragments. J Protein Chemistry 1990; 9:467–473.

    Article  CAS  Google Scholar 

  69. Gao J, Mathias RT, Cohen IS, Baldo GJ. [Ca2+]i determines the effects of isoproterenol on the Na/K pump in ventricular myocytes. Biophysic J 1992; 61:A445.

    Google Scholar 

  70. Lee CO, Vassalle M. Modulation of intracellular Na+ activity and cardiac force by norepinephrine and Ca2+. Am J Physiol 1983; 244:C110–C114.

    PubMed  CAS  Google Scholar 

  71. Pecker MS, Im WB, Sonn JK, Lee CO. Effects of norepinephrine and cyclic AMP on intracellular sodium ion activity and contractile force in canine cardiac Purkinje fibers. Circ Res 1986; 59:390–397.

    PubMed  CAS  Google Scholar 

  72. Wasserstrom JA, Schwartz DJ, Fozzard HA. Catecholamine effects on intracellular sodium activity and tension in dog heart. Am J Physiol 1982; 243:H670–H675.

    PubMed  CAS  Google Scholar 

  73. Chae SW, Wang DY, Gong OY, Lee CO. Effect of norepinephrine on Na+-K+ pump and Na+ influx in sheep cardiac Purkinje fibers. Am J Physiol 1990; 258:C713–722.

    PubMed  CAS  Google Scholar 

  74. Clausen T. Regulation of active Na+-K+ transport in skeletal muscle. Physiol Rev 1986; 66:542–480.

    PubMed  CAS  Google Scholar 

  75. Clausen T, Van Hardeveld C, Everts ME. Significance of cation transport in control of energy metabolism and thermogenesis. Physiol Rev 1991; 71:733–774.

    PubMed  CAS  Google Scholar 

  76. Weil E, Sasson S, Gutman Y. Mechanism of insulin-induced activation of Na+-K+-ATPase in isolated rat soleus muscle. Am J Physiol 1991; 261:C224–230.

    PubMed  CAS  Google Scholar 

  77. Joiner CH, Lauf PK. Modulation of ouabain binding and potassium fluxes by cellular sodium and potassium in human and sheep erythrocytes. J Physiol 1978; 283:177–196.

    PubMed  CAS  Google Scholar 

  78. Bodeman HH, Hoffman JF. Side-dependent effects of internal versus external Na and K on ouabain binding to reconstituted human red blood cell ghosts. J Gen Physiol 1976; 67:497–525.

    Article  Google Scholar 

  79. Zierler K. Insulin, membrane polarization and ionic currents. In: Cuatrecasas P, Jacobs S, eds. Insulin: Handbook of Experimental Pharmacology. Berlin: Springer-Verlag; 1990:421–450.

    Google Scholar 

  80. Smart JL, Deth RC. Influence of alpha 1-adrenergic receptor stimulation and phorbol esters on hepatic Na+/K+-ATPase activity. Pharm 1988; 37: 94–104.

    Article  CAS  Google Scholar 

  81. Middleton JP, Raymond JR, Whorton AR, Dennis W. Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells. J Clin Invest 1990; 86:1799–1805.

    Article  PubMed  CAS  Google Scholar 

  82. Turaihi K, Khokher MA, Barradas MA, Mikhailidis DP, Dandona P. 86Rb(K) influx and [3H]ouabain binding by human platelets: Evidence for beta-adrenergic stimulation of Na-K ATPase activity. Metabolism: Clinical & Experimental 1989; 38:773–776.

    CAS  Google Scholar 

  83. Borin M, Siffert W. Further characterization of the mechanisms mediating the rise in cytosolic free Na+ in thrombin-stimulated platelets. Evidence for inhibition of the Na+, K+-ATPase and for Na+ entry via a Ca2+ influx pathway. J Biol Chem 1991; 266:13153–13160.

    PubMed  CAS  Google Scholar 

  84. Piomelli D, Pilon C, Giros B, Sokoloff P, Martres MP, Schwartz JC. Dopamine activation of the arachidonic acid cascade as a basis for Di/D2 receptor synergism. Nature 1991; 353:164–167.

    Article  PubMed  CAS  Google Scholar 

  85. Aperia A, Bertorello A, Seri I. Dopamine causes inhibition of Na+-K+-ATPase activity in rat proximal convoluted tubule segments. Am J Physiol 1987; 252:F39–F45.

    PubMed  CAS  Google Scholar 

  86. Bertorello A, Aperia A. Inhibition of proximal tubule Na+-K+-ATPase activity requires simultaneous activation of DAI and DA2 receptors. Am J Physiol 1990; 259:F924–F928.

    PubMed  CAS  Google Scholar 

  87. Charlton JA, Baylis PH. Stimulation of rat renal medullary Na+/K+-ATPase by arginine vasopressin is mediated by the V2 receptor. J Endocrinol 1990; 127:213–216.

    Article  PubMed  CAS  Google Scholar 

  88. Brodsky JL. Insulin activation of brain Na+-K+-ATPase is mediated by alpha 2-form of enzyme. Am J Physiol 1990; 258:C812–C817.

    PubMed  CAS  Google Scholar 

  89. Resh MD, Nemenoff RA, Guidotti G. Insulin stimulation of (Na+, K+)-adenosine triphosphatase-dependent 86Rb+ uptake in rat adipocytes. J Biol Chem 1980; 255:10938–10945.

    PubMed  CAS  Google Scholar 

  90. Lytton J, Lin JC, Guidotti G. Identification of two molecular forms of (Na+, K+)-ATPase in rat adipocytes: Relation to insulin stimulation of the enzyme. J Biol Chem 1985; 260:1177–1184.

    PubMed  CAS  Google Scholar 

  91. Lytton J. Insulin affects the sodium affinity of the rat adipocyte (Na+ + K+)-ATPase. J Biol Chem 1985; 260:10075–10080.

    PubMed  CAS  Google Scholar 

  92. Clausen T, Hansen O. Active Na-K transport and the rate of ouabain binding: The effect of insulin and other stimuli on skeletal muscle and adipocytes. J Physiol 1977; 270:415–430.

    PubMed  CAS  Google Scholar 

  93. McGill DL. Characterization of the adipocyte ghost (Na+, K+) pump. Insights into the insulin regulation of the adipocyte (Na+, K+) pump. J Biol Chem 1991; 266:15817–15823.

    PubMed  CAS  Google Scholar 

  94. Note added in proof. Recent studies strengthen the evidence that the Na, K-ATPase is regulated via protein kinases.94–98.

    Google Scholar 

  95. Bertorello AM, Aperia A, Walaas SI, Nairn AC, Greengard P. Phosphorylation of the catalytic subunit of Na+, K+-ATPase inhibits the activity of the enzyme. Proc Natl Acad Sei 1991; 88:11359–11362.

    Article  CAS  Google Scholar 

  96. Vasilets LA, Schwarz W. Regulation of endogenous and expressed Na+/K+ pumps in Xenopus cocytes by membrane potential and stimulation of protein kinases. J Memb Biol 1992; 125:119–243.

    Article  CAS  Google Scholar 

  97. Chibalin AV, Vasilets LA, Hennekes H, Pralong D, Geering K. Phosphorylation of Na, K-ATPase alpha-subunits in microsomes and in homogenates of Xenopus oocytes resulting from the stimulation of protein kinase A and protein kinase C. J Biol Chem 1992; 267:22378–22384.

    PubMed  CAS  Google Scholar 

  98. Chibalin AV, Lopina OD, Petukhov SP, Vasilets LA. Phosphorylation of the Na, K-ATPase by Ca, phospholipid-dependent and cAMP-dependent protein kinases. Mapping of the region phosphorylated by Ca, phospholipid-dependent protein kinase. J Bioenerg Biomemb 1993; 25:61–66.

    Article  CAS  Google Scholar 

  99. Ibarra F, Aperia A, Svensson LB, Eklof AC, Greengard P. Bidirectional regulation of Na+, K+-ATPase activity by dopamine and an alpha-adrenergic agonist. Proc Natl Acad Sei USA 1993; 90:21–24.

    Article  CAS  Google Scholar 

Download references

Authors
  1. Douglas R. Yingst
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. 48323, 2104 Rhine Road, West Bloomfield, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Physiology, Wayne State University, 48202, Detroit, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  3. Section of Endocrinology,Department of Internal Medicine,School of Medicine, Wayne State University, 48202, Detroit, MI, USA

    Mary F. Walsh Ph.D. (Assistant Professor) (Assistant Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Yingst, D.R. (1994). Hormonal Modulation of Sodium Pump Activity: Identification of Second Messengers. In: Foà, P.P., Walsh, M.F. (eds) Ion Channels and Ion Pumps. Endocrinology and Metabolism, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2596-6_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-2596-6_11

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7599-2

  • Online ISBN: 978-1-4612-2596-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation