Abstract
In vitro experiments and experiments with artificial capillary systems suggest that transfer of oxygen from cell-free carriers to tissue sites may be faster than it is from red blood cells. On first consideration, this appears to be advantageous, but new data obtained by direct measurements in the microcirculation indicate that facilitated release may actually lead to an autoregulatory decrease in capillary perfusion. This leads to the conclusion that the well-known hemoglobin-oxygen equilibrium curve may not be adequate by itself to describe oxygen delivery by cell-free hemoglobin-based red cell substitutes to achieve optimal tissue oxygenation.
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Vandegriff, K.D., Winslow, R.M. (1995). A Theoretical Analysis of Oxygen Transport: A New Strategy for the Design of Hemoglobin-Based Red Cell Substitutes. In: Winslow, R.M., Vandegriff, K.D., Intaglietta, M. (eds) Blood Substitutes. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-2576-8_10
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