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Molecular Cytogenetic Stratification of Renal Cell Tumors

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Biology of Renal Cell Carcinoma

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Abstract

The incidence of renal cell carcinoma in the population is 5–10 per 100,000. There is no satisfactory screening method for early detection. About 40% of the patients have metastatic disease at the time of diagnosis and one-third of the remainder will develop distant metastases during the postoperative course. The most effective therapy for RCC localized to the kidney is surgery, whereas a metastatic tumor is practically incurable. The overall response to biological response modifiers is low and the treatment is only palliative in the vast majority of cases. The goal of future therapy is to target specific tumor suppressor genes and other tumor-related genes. Therefore, it is important that genetics be incorporated into the evaluation of renal cell neoplasms in an attempt to provide a foundation for an appropriate diagnosis and selective treatment.

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Authors and Affiliations

  1. Laboratory of Molecular Oncology, Department of Urology, Ruprecht-Karls University of Heidelberg, Heidelberg, Germany

    Gyula Kovacs MD, PhD.

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  1. Gyula Kovacs MD, PhD.
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© 1995 Springer-Verlag New York Inc.

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Kovacs, G. (1995). Molecular Cytogenetic Stratification of Renal Cell Tumors. In: Biology of Renal Cell Carcinoma. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2536-2_2

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  • DOI: https://doi.org/10.1007/978-1-4612-2536-2_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7571-8

  • Online ISBN: 978-1-4612-2536-2

  • eBook Packages: Springer Book Archive

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