T-Lymphocyte Response in Renal Cell Carcinoma

  • Kyogo Itoh
  • Lazel B. Augustus
  • Masanobu Nakao
  • Jiro Miyajima
  • Omar Eton
  • David A. Swamson
Conference paper


Several important immunological properties of tumor-infiltrating lymphocytes (TIL) from renal cell carcinoma (RCC) have been reported: (a) the magnitude of lymphocyte infiltration in RCC was higher than that in the other cancers (1); (b) the autologous tumor cell lysis in IL-2-activated TIL from RCC was higher than that in the other cancers except metastatic melanoma (1–4); (c) non-T cells, including CD3-CD56 + or CD3-CD16+ natural killer cells, were primarily responsible for autologous tumor cell lysis (1–5); (d) T cells were enriched with memory T cell markers (6); and (e) IL-2-activated TIL showed oligoclonal expansion (7–9). Therefore, TIL in RCC appeared to be more involved in host tumor-interaction than PBMC. However, there are few findings, to our knowledge, supporting the idea that RCC-specific T cells exist in TIL, PBMC, or the other immune organs in RCC patients. (10) Neither RCC TIL nor PBMC cultured with IL-2 alone displayed tumor-specific cytotoxicity. (1–8) These results suggest that RCC TIL have little or no CTL precursors, possibly because of the lower immunogeneity of untreated RCC cells. Poorly immunogenic animal tumor cells can be converted into highly immunogenic tumors by several techniques: (a) viral infection of tumor cells (11,12), (b) treatment of tumor cells with mutagenic agents such as 1-methyl-3-nitro-l-nitrosoguanidine (13, 14), (c) treatment of tumor cells with ultraviolet-B (UV) radiation or the others (15–19), (d) transfection of tumor cells with MHC class I antigens (20,21), and (e) transfection of tumor cells with cytokine genes (22, 23).


Renal Cell Carcinoma Peripheral Blood Mononuclear Cell Renal Cell Carcinoma Cell Renal Cell Carcinoma Patient Autologous Tumor Cell 
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Copyright information

© Springer-Verlag New York Inc. 1995

Authors and Affiliations

  • Kyogo Itoh
    • 1
  • Lazel B. Augustus
    • 2
  • Masanobu Nakao
    • 1
  • Jiro Miyajima
    • 1
  • Omar Eton
    • 3
  • David A. Swamson
    • 4
  1. 1.Department of ImmunologyKurume University School of MedicineKurumeJapan
  2. 2.Department of ImmunologyUniversity of Texas, M.D. Anderson Cancer CenterHoustonUSA
  3. 3.Department of Medical OncologyUniversity of Texas, M.D.Anderson Cancer CenterHoustonUSA
  4. 4.Department of UrologyUniversity of Texas, M.D. Anderson Cancer CenterHoustonUSA

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