Impact of Growth Hormone on the Timing and Progression of Puberty: How Are Growth and Sexual Maturation Linked?

  • Paul A. Boepple
Conference paper
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)


Perhaps nowhere else are the interactions between the somatotrophic and reproductive axes as dramatically manifest as when sexual maturation and the adolescent growth spurt combine to comprise human pubertal development. Basic and clinical investigations in recent years have added much to our knowledge regarding these complex interactions, including the modulation of neurosecretory patterns of growth hormone (GH) release by gonadal steroids and the modulation of gonadal function by insulin-like growth factor I (IGF-I) and its binding proteins (IGFBPs) (1-3). The focus of this chapter is the impact of growth and GH on two discrete aspects of sexual maturation: (i) the timing of the onset of central puberty and (ii) the pace or rapidity with which puberty progresses once under way. While they are areas of great clinical and basic research interest, there is still much that is poorly understood about these developmental processes.


Growth Hormone Sexual Maturation Central Precocious Puberty Pubertal Maturation Growth Hormone Administration 
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  1. 1.
    Kerrigan JR, Rogol AD. The impact of gonadal steroid hormone action on growth hormone secretion during childhood and adolescence. Endocr Rev 1992; 13: 281–98.PubMedGoogle Scholar
  2. 2.
    Adashi EY, Resnick CE, D’Ercole AJ, Svoboda ME, Van Wyk JJ. Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocr Rev 1985; 6: 400–20.PubMedCrossRefGoogle Scholar
  3. 3.
    Adashi EY. Intraovarian regulation: the proposed role of insulin-like growth factors. Ann NY Acad Sci 1993; 687: 10–2.PubMedCrossRefGoogle Scholar
  4. 4.
    Tannenbaum GS. Neuroendocrine control of growth hormone secretion. Acta Paediatr Scand Suppl 1991; 372: 5–16.PubMedCrossRefGoogle Scholar
  5. 5.
    Millard WJ, Martin JB Jr, Audet J, Sagar SM, Martin JB. Evidence that reduced growth hormone secretion observed in monosodium glutamate-treated rats is the result of a deficiency in growth hormone-releasing factor. Endocrinology 1982; 110: 540–50.PubMedCrossRefGoogle Scholar
  6. 6.
    Meister B, Ceccatelli S, Hokfelt T, Anden NE, Anden M, Theodorsson E. Neurotransmitters, neuropeptides and binding sites in the rat mediobasal hypothalamus: effects of monosodium glutamate (MSG) lesions. Exp Brain Res 1989; 76: 343–68.PubMedCrossRefGoogle Scholar
  7. 7.
    Thorner MO, Vance ML, Evans WS, et al. Physiological and clinical studies of GRF and GH. Recent Prog Horm Res 1986; 42: 589–640.PubMedGoogle Scholar
  8. 8.
    Sauder SE, Corley KP, Hopwood NJ, Kelch RP. Subnormal gonadotropin responses to gonadotropin-releasing hormone persist into puberty in children with isolated growth hormone deficiency. J Clin Endocrinol Metab 1981; 53: 1186–92.PubMedCrossRefGoogle Scholar
  9. 9.
    Burns EC, Tanner JM, Preece MA, Cameron N. Final height and pubertal development in 55 children with idiopathic growth hormone deficiency, treated for between 2 and 15 years with human growth hormone. Eur J Pediatr 1981; 137: 155–64.PubMedGoogle Scholar
  10. 10.
    Hibi I, Tanaka T. Final height of patients with idiopathic growth hormone deficiency after long-term growth hormone treatment: Committee for Treatment of Growth Hormone Deficient Children, Growth Science Foundation, Japan. Acta Endocrinol (Copenh) 1989; 120: 409–15.PubMedGoogle Scholar
  11. 11.
    Darendeliler F, Hindmarsh PC, Preece MA, Cox L, Brook CG. Growth hormone increases rate of pubertal maturation. Acta Endocrinol (Copenh) 1990; 122: 414–6.PubMedGoogle Scholar
  12. 12.
    Stanhope R, Albanese A, Hindmarsh P, Brook CG. The effects of growth hormone therapy on spontaneous sexual development. Horm Res 1992; 38 (suppl 1): 9–13.PubMedCrossRefGoogle Scholar
  13. 13.
    Arsenijevic Y, Wehrenberg WB, Conz A, Eshkol A, Sizonenko PC, Aubert ML. Growth hormone (GH) deprivation induced by passive immunization against rat GH-releasing factor delays sexual maturation in the male rat. Endocrinology 1989; 124: 3050–9.PubMedCrossRefGoogle Scholar
  14. 14.
    Steeman SL, Glitzer MS, Ostlind DA, Mueller JF. Biological properties of the growth hormonelike factor from the plerocercoid of Spirometra mansonoides. Recent Prog Horm Res 1971; 27: 97–120.Google Scholar
  15. 15.
    Garland JT, Daughaday WH. Feedback inhibition of pituitary growth hormone in rats infected with Spirometra mansonoides. Proc Soc Exp Biol Med 1972; 139: 497–9.PubMedGoogle Scholar
  16. 16.
    Ramaley JA, Phares CK. Delay of puberty onset in females due to suppression of growth hormone. Endocrinology 1980; 106: 1989–93.PubMedCrossRefGoogle Scholar
  17. 17.
    Ramaley JA, Phares CK. Delay of puberty onset in males due to suppression of growth hormone. Neuroendocrinology 1983; 36: 321–9.PubMedCrossRefGoogle Scholar
  18. 18.
    Frisch RE, Revelle R. Height and weight at menarche and a hypothesis of critical body weights and adolescent events. Science 1970; 169: 397–9.PubMedCrossRefGoogle Scholar
  19. 19.
    Frisch RE, McArthur JW. Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset. Science 1974; 185: 949–51.PubMedCrossRefGoogle Scholar
  20. 20.
    Frisch RE. Pubertal adipose tissue: is it necessary for normal sexual maturation? Evidence from the rat and human female. Fed Proc 1980; 39: 2395–400.PubMedGoogle Scholar
  21. 21.
    Boyar RM. Endocrine changes in anorexia nervosa. Med Clin North Am 1978; 62: 297–303.PubMedGoogle Scholar
  22. 22.
    Cameron JL, Weltzin TE, McConaha C, Helmreich DL, Kaye WH. Slowing of pulsatile luteinizing hormone secretion in men after forty-eight hours of fasting. J Clin Endocrinol Metab 1991; 73: 35–41.PubMedCrossRefGoogle Scholar
  23. 23.
    Schreihofer DA, Parfitt DB, Cameron JL. Suppression of luteinizing hormone secretion during short-term fasting in male rhesus monkeys: the role of metabolic versus stress signals [see comments]. Endocrinology 1993; 132: 1881–9.PubMedCrossRefGoogle Scholar
  24. 24.
    Cemmons DR, Klibanski A, Underwood LE, et al. Reduction of plasma immunoreactive somatomedin C during fasting in humans. J Clin Endocrinol Metab 1981; 53: 1245–7.Google Scholar
  25. 25.
    Ho KY, Veldhuis JD, Johnson ML, et al. Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest 1988; 81: 968–75.PubMedCrossRefGoogle Scholar
  26. 26.
    Bourguignon JP, Gerard A, Alvarez Gonzalez ML, Fawe L, Franchimont P. Effects of changes in nutritional conditions on timing of puberty: clinical evidence from adopted children and experimental studies in the male rat. Horm Res 1992; 38 (suppl 1): 97–105.PubMedCrossRefGoogle Scholar
  27. 27.
    Suttie JM, Kostyo JL, Ebling FJ, et al. Metabolic interfaces between growth and reproduction, IV. Chronic pulsatile administration of growth hormone and the timing of puberty in the female sheep. Endocrinology 1991; 129: 2024–32.PubMedCrossRefGoogle Scholar
  28. 28.
    Wilson ME, Gordon TP, Rudman CG, Tanner JM. Effects of growth hormone on the tempo of sexual maturation in female rhesus monkeys. J Clin Endocrinol Metab 1989; 68: 29–38.PubMedCrossRefGoogle Scholar
  29. 29.
    Wilson ME, Tanner JM. Long-term effects of recombinant human growth hormone treatment on skeletal maturation and growth in female rhesus monkeys with normal pituitary function. J Endocrinol 1991; 130: 435–41.PubMedCrossRefGoogle Scholar
  30. 30.
    Hopwood NJ, Hintz RL, Gertner JM, et al. Growth response of children with non-growth-hormone deficiency and marked short stature during three years of growth hormone therapy. J Pediatr 1993; 123: 215–22.PubMedCrossRefGoogle Scholar
  31. 31.
    van der Werff ten Bosch JJ, Bot A. Growth of males with idiopathic hypopituitarism without growth hormone treatment. Clin Endocrinol (Oxf) 1990; 32: 707–17.CrossRefGoogle Scholar
  32. 32.
    Zachmann M. Interrelations between growth hormone and sex hormones: physiologic and therapeutic consequences. Horm Res 1992; 38 (suppl 1): 1–18.PubMedCrossRefGoogle Scholar
  33. 33.
    Hibi I, Tanaka T, Tanae A, et al. The influence of gonadal function and the effect of gonadal suppression treatment on final height in growth hormone (GH)-treated GH-deficient children. J Clin Endocrinol Metab 1989; 69: 221–6.PubMedCrossRefGoogle Scholar
  34. 34.
    Boepple PA, Mansfield MJ, Crawford JD, Crigler JF Jr, Blizzard RM, Crowley WF Jr. Analysis of growth data in children with central precocious puberty: the impact of long-term GnRH agonist therapy. In: Grave GD, Cutler GB Jr, eds. Sexual precocity: etiology, diagnosis, and management. New York: Raven Press, 1993: 69–83.Google Scholar
  35. 35.
    Stanhope R, Brook CG. The effect of gonadotrophin releasing hormone analogue on height prognosis in growth hormone deficiency and normal puberty. Eur J Pediatr 1988; 148: 200–2.PubMedCrossRefGoogle Scholar
  36. 36.
    Toublanc JE, Couprie C, Gamier P, Job JC. The effects of treatment combining an agonist of gonadotropin-releasing hormone with growth hormone in pubertal patients with isolated growth hormone deficiency. Acta Endocrinol (Copenh) 1989; 120: 795–9.Google Scholar
  37. 37.
    Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969; 44: 291–303.PubMedCrossRefGoogle Scholar
  38. 38.
    Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970; 45: 13–23.PubMedCrossRefGoogle Scholar

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© Springer-Verlag New York, Inc. 1995

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  • Paul A. Boepple

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