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Impact of Growth Hormone on the Timing and Progression of Puberty: How Are Growth and Sexual Maturation Linked?

  • Paul A. Boepple
Conference paper
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)

Abstract

Perhaps nowhere else are the interactions between the somatotrophic and reproductive axes as dramatically manifest as when sexual maturation and the adolescent growth spurt combine to comprise human pubertal development. Basic and clinical investigations in recent years have added much to our knowledge regarding these complex interactions, including the modulation of neurosecretory patterns of growth hormone (GH) release by gonadal steroids and the modulation of gonadal function by insulin-like growth factor I (IGF-I) and its binding proteins (IGFBPs) (1-3). The focus of this chapter is the impact of growth and GH on two discrete aspects of sexual maturation: (i) the timing of the onset of central puberty and (ii) the pace or rapidity with which puberty progresses once under way. While they are areas of great clinical and basic research interest, there is still much that is poorly understood about these developmental processes.

Keywords

Growth Hormone Sexual Maturation Central Precocious Puberty Pubertal Maturation Growth Hormone Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc. 1995

Authors and Affiliations

  • Paul A. Boepple

There are no affiliations available

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