Abstract
Growth hormone (GH) is an anabolic hormone that stimulates protein synthesis in normal volunteers. Although it also stimulates protein catabolism, the increase in protein synthesis is significantly greater than the concomitant increase in catabolism, resulting in net protein accretion. Two types of interventions have been used to induce catabolism in normal volunteers. These include caloric restriction and administration of glucocorticoids (1, 2). Normal volunteers who received high doses of prednisone to induce nitrogen loss responded to GH with significant improvement in nitrogen balance and an increase in nonoxidative leucine metabolism, which is an index of stimulation of protein synthesis (3). Similarly, several studies in calorically restricted normal volunteers have shown that GH results in protein conservation (4, 5).
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Clemmons, D.R. (1995). Growth Hormone and IGF-I as Anabolic Partitioning Hormones. In: Adashi, E.Y., Thorner, M.O. (eds) The Somatotrophic Axis and the Reproductive Process in Health and Disease. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2518-8_6
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DOI: https://doi.org/10.1007/978-1-4612-2518-8_6
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