Probing and Designing Growth Hormone-Receptor Interactions
The mechanism through which extracellular signals from hormones trigger intracellular responses is central to understanding how cells and tissues interact. The signaling process is initiated by the binding of polypeptide hormones to cell-surface receptors; however, the molecular basis for binding and receptor activation is not well understood. Through a series of mutational and structural studies, the molecular basis for ligand binding and activation of the growth hormone receptor has been revealed in perhaps greater detail than for any other hormone-receptor system (reviewed in 1–3).
KeywordsGrowth Hormone Human Growth Hormone Growth Hormone Receptor Prolactin Receptor Contact Residue
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