Probing and Designing Growth Hormone-Receptor Interactions

  • James A. Wells
  • Anthony A. Kossiakoff
Conference paper
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)

Abstract

The mechanism through which extracellular signals from hormones trigger intracellular responses is central to understanding how cells and tissues interact. The signaling process is initiated by the binding of polypeptide hormones to cell-surface receptors; however, the molecular basis for binding and receptor activation is not well understood. Through a series of mutational and structural studies, the molecular basis for ligand binding and activation of the growth hormone receptor has been revealed in perhaps greater detail than for any other hormone-receptor system (reviewed in 1–3).

Keywords

Zinc HPLC Filtration Lymphoma Tyrosine 

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Copyright information

© Springer-Verlag New York, Inc. 1995

Authors and Affiliations

  • James A. Wells
  • Anthony A. Kossiakoff

There are no affiliations available

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