Skip to main content
SpringerLink
Log in

Ovarian IGF System: Interface with the Gonadotropic and Somatotrophic Axes

  • Conference paper
The Somatotrophic Axis and the Reproductive Process in Health and Disease

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

  • 74 Accesses

Abstract

This brief chapter outlines the several components of the ovarian insulin-like growth factor (IGF) system and their physiological regulation. Collectively, these data support a critical role for this system in the development and selection of ovarian follicles. Although the role of this system in luteal function is less secure, current evidence also supports a potential role in that ovarian tissue. These data involve descriptive studies in vivo or in vitro that fall short of compelling proof of an obligatory role for locally secreted IGFs in ovarian function in vivo. However, IGF-I gene disruption experiments have now been conducted in transgenic mice (1); further analysis of effects on ovarian function should provide critical missing information in this regard.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Liu J-P, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGF-I) and type I IGF receptor (IGFIr). Cell 1993; 75: 59–72.

    PubMed  CAS  Google Scholar 

  2. Giudice LC. Insulin-like growth factors and ovarian follicular development. Endocr Rev 1992; 13: 641–69.

    PubMed  CAS  Google Scholar 

  3. Hammond JM, Baranao JLS, Skaleris D, Knight AB, Romanus JA, Rechler MM. Production of insulin-like growth factors by ovarian granulosa cells. Endocrinology 1975; 117: 2553–5.

    Article  Google Scholar 

  4. Samaras SE, Hagen DR, Bryan KA, Mondschein JS, Canning SF, Hammond JM. Effects of growth hormone and gonadotropin on the insulin-like growth factor system in the porcine ovary. Biol Reprod 1994; 50: 178–86.

    Article  PubMed  CAS  Google Scholar 

  5. Hammond JM, Samaras SE, Grimes R, et al. Intraovarian regulation in the porcine ovary: the role of insulin-like growth factors and epidermal growth factor-related peptides. J Reprod Fertil Suppl 1993; 48: 117–25.

    PubMed  CAS  Google Scholar 

  6. Samaras S, Guthrie D, Barber J, Hammond JM. Changes in mRNAs for the insulin-like growth factors and their binding proteins in individual porcine ovarian follicles. Endocrinology 1993; 133: 2395–8.

    Article  PubMed  CAS  Google Scholar 

  7. Hammond JM, Hsu C-J, Klindt J, Tsang BK, Downey BR. Gonadotropins increase concentrations of immunoreactive insulin-like growth factor-I in porcine follicular fluid in vivo. Biol Reprod 1988; 38: 304–8.

    Article  PubMed  CAS  Google Scholar 

  8. Hsu C-J, Hammond JM. Gonadotropins and estradiol stimulate immunoreactive insulin-like growth factor-I production by porcine granulosa cells in vitro. Endocrinology 1987; 120: 198–207.

    Article  PubMed  CAS  Google Scholar 

  9. Mondschein JS, Hammond JM. Growth factors regulate immunoreactive insulin-like growth factor-I production by cultured porcine granulosa cells. Endocrinology 1988; 123: 463–8.

    Article  PubMed  CAS  Google Scholar 

  10. Ramasharma K, Li CH. Human pituitary and placental hormones control human insulin-like growth factor II secretion in human granulosa cells. Proc Natl Acad Sci USA 1987; 94: 2643–7.

    Article  Google Scholar 

  11. Voutilainen R, Miller WL. Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain-cleavage enzyme P450scc, in human steroidogenic tissues. Proc Natl Acad Sci USA 1987; 84: 1590–4.

    Article  PubMed  CAS  Google Scholar 

  12. Oliver JE, Aitman TJ, Powell JF, Wilson CA, Clayton RN. Insulin-like growth factor I gene expression in the rat ovary is confined to the granulosa cells of developing follicles. Endocrinology 1989; 124: 2671–9.

    Article  PubMed  CAS  Google Scholar 

  13. Botero LF, Roberts CT Jr, LeRoith D, Adashi EY, Hernandez ER. Insulin-like growth factor I gene expression by primary cultures of ovarian cells: insulin and dexamethasone dependence. Endocrinology 1993; 132: 2703–8.

    Article  PubMed  CAS  Google Scholar 

  14. Hammond JM, Veldhuis JD, Seal TW, Rechler MM. Intraovarian regulation of granulosa-cell replication. In: Channing CP, Segal SJ, eds. Intraovarian control mechanisms, New York: Plenum Press, 1982: 341–56.

    Google Scholar 

  15. Mondschein JS, Etherton TD, Hammond JM. Characterization of insulin-like growth factor-binding proteins of porcine ovarian follicular fluid. Biol Reprod 1991; 44: 315–20.

    Article  PubMed  CAS  Google Scholar 

  16. Mondschein JS, Smith SA, Hammond JM. Production of insulin-like growth factor binding proteins (IGFBPs) by porcine granulosa cells; identification of IGFBP-2 and -3 and regulation by hormones and growth factors. Endocrinology 1990; 127: 2298–307.

    Article  PubMed  CAS  Google Scholar 

  17. Seppala M, Wahlstrom T, Koskimies Al, et al. Human preovulatory follicles and corpus luteum contain placental protein 12. J Clin Endocrinol Metab 1984; 58: 505–10.

    Article  PubMed  CAS  Google Scholar 

  18. Shimasaki S, Ling N. Identification and molecular characterization of insulin-like growth factor binding proteins (IGFBP-1, -2, -3, -4, -5, and -6). Prog Growth Fact Res 1991; 3: 243–66.

    Article  CAS  Google Scholar 

  19. Hammond JM, Barber JA, Canning SF, Guthrie HD. Expression of insulin-like growth factor binding proteins-4 and -5 during the growth of porcine ovarian follicles [Abstract]. Biol Reprod 1992; 46 (suppl 1): 85.

    Google Scholar 

  20. Howard HJ, Ford JJ. Relationships among concentrations of steroids, inhibin, insulin-like growth factor-I (IGF-I), and IGF-binding proteins during follicular development in weaned sows. Biol Reprod 1992; 47: 193–201.

    Article  PubMed  CAS  Google Scholar 

  21. Grimes RW, Hammond JM. Insulin and insulin-like growth factors (IGFs) stimulate production of IGF-binding proteins by ovarian granulosa cells. Endocrinology 1992; 131: 553–8.

    Article  PubMed  CAS  Google Scholar 

  22. Grimes RW, Samaras SE, Barber JA, Shimasaki S, Ling N, Hammond JM. Gonadotropin and cAMP modulation of IGF binding protein production in ovarian granulosa cells. Am J Physiol 1992; 262: 3497–503.

    Google Scholar 

  23. Grimes RW, Barber JA, Shimasaki S, Ling N, Hammond JM. Porcine ovarian granulosa cells secrete insulin-like growth factor (IGF)-binding proteins-4 and -5 and express their mRNAs: regulation by FSH and IGF-I. Biol Reprod 1994; 50: 695–701.

    Article  PubMed  CAS  Google Scholar 

  24. Adashi EY, Resnick CE, Hernandez ER, Hurwitz A, Rosenfeld RG. Follicle-stimulating hormone inhibits the constitutive release of insulin-like growth factor binding proteins by cultured rat ovarian granulosa cells. Endocrinology 1990; 126: 1305.

    Article  PubMed  CAS  Google Scholar 

  25. Adashi EY, Resnick CE, Tedeschi C, Rosenfeld RG. A kinase-mediated regulation of granulosa cell-derived insulin-like growth factor binding proteins (IGFBPs): disparate response sensitivities of distinct IGFBP species. Endocrinology 1993; 132: 1463–8.

    Article  PubMed  CAS  Google Scholar 

  26. Liu X-J, Malkowski M, Guo Y, Erickson GF, Shimasaki S, Ling N. Development of specific antibodies to rat insulin-like growth factor-binding proteins (IGFBP-2 to -6): analysis of IGFBP production by rat granulosa cells. Endocrinology 1993; 132: 1176–83.

    Article  PubMed  CAS  Google Scholar 

  27. Grimes RW, Hammond JM. Proteolytic degradation of insulin-like growth factor-binding protein-3 by porcine ovarian granulosa cells in culture: regulation by IGF-I. Endocrinology 1994; 134: 337–43.

    Article  PubMed  CAS  Google Scholar 

  28. Fielder PJ, Pham H, Adashi EY, Rosenfeld RG. Insulin-like growth factors (IGFs) block FSH-induced proteolysis of IGF-binding protein-5 (BP-5) in cultured rat granulosa cells. Endocrinology 1993; 133: 415–8.

    Article  PubMed  CAS  Google Scholar 

  29. Hammond JM, English HF. Regulation of DNA synthesis in cultured porcine granulosa cells by growth factors and hormones. Endocrinology 1987; 120: 1039–46.

    Article  PubMed  CAS  Google Scholar 

  30. May JV, Frost JP, Schomberg DW. Differential effects of epidermal growth factor, somatomedin-C/insulin-like growth factor I, and transforming growth factor-beta on porcine granulosa cell deoxyribonucleic acid synthesis and cell proliferation. Endocrinology 1988; 123: 168–79.

    Article  PubMed  CAS  Google Scholar 

  31. Chakravorty A, Joslyn M, Davis JS. Synergistic interactions among the adenylate cyclase (LH/cAMP) and tyrosine kinase (insulin/IGF-I) systems in bovine luteal cells [Abstract #165]. Biol Reprod 1992; 46 (suppl 1): 92.

    Google Scholar 

  32. Samaras SE, Hammond JM. Inhibitory actions of recombinant IGFBP-3 on the function of cultured porcine granulosa cells [Abstract]. Prog IX Ovarian Workshop on Ovarian Cell Interactions: Genes to Physiology, Chapel Hill, NC, 1992.

    Google Scholar 

  33. Ui M, Shimonaka M, Shimasaki S, Ling N. An insulin-like growth factor binding protein in ovarian follicular fluid blocks follicle-stimulating hormone-stimulated steroid production by ovarian granulosa cells. Endocrinology 1989; 125: 912–6.

    Article  PubMed  CAS  Google Scholar 

  34. Bicsak TA, Shimonaka M, Malkowski M, Ling N. Insulin-like growth factor-binding protein (IGFBP) inhibition of granulosa cell function: effect on cyclic adenosine 3′,5′-monophosphate, deoxyribonucleic acid synthesis, and comparison with the effect of an IGF-I antibody. Endocrinology 1990; 126: 2184–9.

    Article  PubMed  CAS  Google Scholar 

  35. Bicsak TA, Ling N, DePaolo LV. Ovarian intrabursal administration of insulin-like growth factor-binding protein inhibits follicle rupture in gonadotropin-treated immature rats. Biol Reprod 1991; 44: 599–603.

    Article  PubMed  CAS  Google Scholar 

  36. Conover CA, Ronk M, Lombana F, Powell DR. Structural and biological characterization of bovine insulin-like growth factor binding protein-3. Endocrinology 1990; 127: 2795–803.

    Article  PubMed  CAS  Google Scholar 

  37. Mason HD, Willis D, Holly JM, Cwyfan-Hughes SC, Seppala M, Franks S. Inhibitory effects of insulin-like growth factor-binding proteins on steroido-genesis by human granulosa cells in culture. Mol Cell Endocrinol 1992; 89: R1–4.

    Article  PubMed  CAS  Google Scholar 

  38. Adashi EY, Resnick CE, Ricciarelli E, et al. Granulosa cell-derived insulin-like growth factor (IGF) binding proteins are inhibitory to IGF-I hormonal action: evidence derived from the use of a truncated IGF-I analogue. J Clin Invest 1992; 90: 1593–9.

    Article  PubMed  CAS  Google Scholar 

  39. Oh Y, Muller HL, Lamson G, Rosenfeld RG. Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells: cell surface binding and growth inhibition. J Biol Chem 1993; 268: 14964–71.

    PubMed  CAS  Google Scholar 

  40. Cohen P, Lamson G, Okajima T, Rosenfeld RG. Transfection of the human insulin-like growth factor binding protein-3 gene into balb/c fibroblasts inhibits cellular growth. Mol Endocrinol 1993; 7: 380–6.

    Article  PubMed  CAS  Google Scholar 

  41. Clemmons DR. Insulin-like growth factor binding proteins: roles in regulating IGF physiology. J Dev Physiol 1991; 15: 105–10.

    PubMed  CAS  Google Scholar 

  42. Rechler MM. Insulin-like growth factor binding proteins. Vitam Horm 1993; 47: 1–114.

    Article  PubMed  CAS  Google Scholar 

  43. Hsu C-J, Hammond JM. Concomitant effects of growth hormone on secretion of insulin-like growth factor-I and progesterone by cultured porcine granulosa cells. Endocrinology 1987; 121: 1343–8.

    Article  PubMed  CAS  Google Scholar 

  44. Mondschein JS, Canning SF, Miller DO, Hammond JM. Insulin-like growth factors (IGFs) as autocrine/paracrine regulators of granulosa cell differentiation and growth: studies with a neutralizing monoclonal antibody to IGF-I. Biol Reprod 1989; 40: 79–85.

    Article  Google Scholar 

  45. Hammond JM, Mondschein JS, Samaras SE, Smith SA, Hagen DR. The ovarian insulin-like growth factor system. J Reprod Fertil 1991; 43 (suppl): 199–208.

    CAS  Google Scholar 

  46. Armstrong JD, Britt JH, Flowers WL, Campbell RM, Heimer EP. Effect of immunization against growth hormone releasing factor (GRFi) on onset of puberty and ovulation rate in gilts [Abstract #271]. Biol Reprod 1993; 48 (suppl 1): 126.

    Google Scholar 

  47. Bryan KA, Hammond JM, Canning S, et al. Reproductive and growth responses of gilts to exogenous porcine pituitary growth hormone. J Anim Sci 1989; 67: 196–205.

    PubMed  CAS  Google Scholar 

  48. Guthrie HD, Pursel VG, Bolt DJ, Cooper BS. Expression of a bovine growth hormone transgene inhibits pregnant mare’s serum gonadotropin-induced follicle maturation in prepuberal gilts. J Anim Sci 1993; 71: 3409–13.

    PubMed  CAS  Google Scholar 

  49. Spicer LH, Klindt J, Bunomo FC, Maurer R, Yen JT, Echternkamp SE. Effect of porcine somatotropin on number of granulosa cell luteinizing hormone/human chorionic gonadotropin receptors, oocyte viability, and concentrations of steroids and insulin-like growth factors I and II in follicular fluid of lean and obese gilts. J Anim Sci 1992; 70: 3149–57.

    PubMed  CAS  Google Scholar 

  50. Kirkwood RN, Thacker PA, Korchinski RS, Laarveld B. The influence of exogenous pituitary growth hormone on the ovulatory responses to PMSG and hCG and the LH response to estradiol benzoate in prepubertal gilts. Domest Anim Endocrinol 1988; 55: 61–9.

    Google Scholar 

Download references

Authors
  1. James M. Hammond
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Susan Samaras
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Randall Grimes
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Daniel Hagen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. David Guthrie
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA

    Eli Y. Adashi M.D.

  2. Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia, 22908, USA

    Michael O. Thorner M.B., D.Sc.

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag New York, Inc.

About this paper

Cite this paper

Hammond, J.M., Samaras, S., Grimes, R., Hagen, D., Guthrie, D. (1995). Ovarian IGF System: Interface with the Gonadotropic and Somatotrophic Axes. In: Adashi, E.Y., Thorner, M.O. (eds) The Somatotrophic Axis and the Reproductive Process in Health and Disease. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2518-8_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-2518-8_15

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7567-1

  • Online ISBN: 978-1-4612-2518-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation