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Extracorporeal Membrane Oxygenation for Severe Cardiorespiratory Failure

  • J. Devn Cornish
Chapter

Abstract

Throughout this volume, the efficacy of cardiopulmonary bypass (CPB) in providing short-term circulatory support is demonstrated. The need for such technology is undisputed, since 375,000 bypass operations are performed annually in the United States, where cardiovascular disease is the leading cause of death.1 Respiratory diseases (not including respiratory complications of neoplastic conditions) are the third leading cause of death. Almost as soon as extracorporeal circulation was conceived as an adjunct to cardiac surgery, its developers recognized its potential application to the treatment of respiratory failure. In many ways, however, the latter is a much more convoluted enterprise. Since circulatory support cannot in any way “treat” underlying pulmonary conditions, at best it can be expected to provide a period of physiologically normal support of sufficient length to allow for intrinsic healing. The long-term use of extracorporeal circulation as a means of supporting patients with life-threatening respiratory (and/or cardiac) failure has come to be known as extracorporeal membrane oxygenation (ECMO) or extracorporeal life support (ECLS).

Keywords

Extracorporeal Membrane Oxygenation Persistent Pulmonary Hypertension Venoarterial ECMO Neonatal Respiratory Failure Neonatal ECMO 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Wegman ME. Annual summary of vital statistics-1990. Pediatrics 1991; 88: 1081–1092.PubMedGoogle Scholar
  2. 2.
    Bartlett RH, Gazzaniga AB, Jefferies MR, Huxtable RF, Haiduc NJ, Fong SW. Extracorporeal membrane oxygenation (ECMO) cardiopulmonary support in infancy. Trans Am Soc Artif Intern Organs 1976; 22: 80–93.PubMedGoogle Scholar
  3. 3.
    Cornish JD, Carter JM, Gerstmann DR, Null DM, Jr. Extracorporeal membrane oxygenation as a means of stabilizing and transporting high risk neonates. ASAIO Trans 1991; 37: 564–568.PubMedGoogle Scholar
  4. 4.
    Rashkind WJ, Freeman A, Klein D, Troft RW. Evaluation of a disposable plastic, low volume, pumpless oxygenator as a lung substitute. JPediatr 1965; 66: 94–102.Google Scholar
  5. 5.
    Dorson WJ, Baker E, Cohen ML, et al. A perfusion system for infants. Trans Am Soc Artif Intern Organs 1969; 15: 155–160.PubMedGoogle Scholar
  6. 6.
    White JJ, Andrews HG, Risemberg H, Mazur D, Haller JA Jr. Prolonged respiratory support in newborn infants with a membrane oxygenator. Surgery 1971; 70: 288–296.PubMedGoogle Scholar
  7. 7.
    Pyle RB, Helton WC, Johnson FW, et al. Clinical use of the membrane oxygenator. Arch Surg 1975; 110: 966–970.PubMedGoogle Scholar
  8. 8.
    Bartlett RH, Gazzaniga AB, Huxtable RF, Schippers HC, O’Connor MJ, Jefferies MR. Extracorporeal circulation (ECMO) in neonatal respiratory failure. J Thorac Cardiovasc Surg 1977; 74: 826–833.PubMedGoogle Scholar
  9. 9.
    Bartlett RH, Gazzaniga AB. Extracorporeal circulation for cardiopulmonary failure. Curr Probl Surg 1978; 15: 1–96.PubMedGoogle Scholar
  10. 10.
    Bartlett RH, Gazzaniga AB, Huxtable RH, et al. Extracorporeal membrane oxygenation (ECMO) in newborn respiratory failure: technical consideration. Trans Am Soc Artif Intern Organs 1979; 25: 473–475.PubMedGoogle Scholar
  11. 11.
    Bartlett RH, Andrews AF, Toomasian JM, Haiduc NJ, Gazzaniga AB. Extracorporeal membrane oxygenation for newborn respiratory failure: forty-five cases. Surgery 1982; 92: 425–433.PubMedGoogle Scholar
  12. 12.
    Kolobow T, Bowman RL. Construction and evaluation of an alveolar membrane artificial heart-lung. Trans Am Soc Artif Intern Organs 1963; 9: 238–243.PubMedGoogle Scholar
  13. 13.
    Kolobow T, Gattinoni L, Tomlinson T, Pierce JE. An alternative to breathing. J Thorac Cardiovasc Surg 1978; 75: 261–266.PubMedGoogle Scholar
  14. 14.
    Kolobow T, Fumagalli R, Arosio P, Chen V, Buckhold DK, Pierce JE. The use of the extracorporeal membrane lung in the successful resuscitation of severely hypoxic and hypercapnic fetal lambs. Trans Am Soc Artif Intern Organs 1982; 28: 365–368.PubMedGoogle Scholar
  15. 15.
    Krummel TM, Greenfield LJ, Kirkpatrick BV, Mueller DG, Ormazabal M, Salzberg AM. Clinical use of an extracorporeal membrane oxygenator in neonatal pulmonary failure. J Pediatr Surg 1982; 17: 525–531.PubMedGoogle Scholar
  16. 16.
    Kirkpatrick BV, Krummel TM, Mueller DG, Ormazabal MA, Greenfield LJ, Salzberg AM. Use of extracorporeal membrane oxygenation for respiratory failure in term infants. Pediatrics 1983; 72: 872–876.PubMedGoogle Scholar
  17. 17.
    Griffith BP, Borovetz HS, Hardesty RL, Hung TK, Bahn-son HT. Arteriovenous ECMO for neonatal respiratory support. A study in perigestational lambs. J Thorac Cardiovasc Surg 1979; 77: 595–601.PubMedGoogle Scholar
  18. 18.
    Hardesty RL, Griffith BP, Debski RF, Jeffries MR, Borovetz HS. Extracorporeal membrane oxygenation. Successful treatment of persistent fetal circulation following repair of congenital diaphragmatic hernia. J Thorac Cardiovasc Surg 1981; 81: 556–563.PubMedGoogle Scholar
  19. 19.
    Hill JD, O’Brien TG, Murray JJ, et al. Prolonged extracorporeal oxygenation for acute post-traumatic respiratory failure (shock-lung syndrome). Use of the Bramson Membrane Lung. N Engl J Med 1972; 286: 629–634.PubMedGoogle Scholar
  20. 20.
    Zapol WM, Snider MT, Hill JD, et al. Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study. JAMA 1979; 242: 2193–2196.PubMedGoogle Scholar
  21. 21.
    Pierce EC. Is extracorporeal membrane oxygenation a viable technique? Ann Thorac Surg 1981; 31: 102–104.Google Scholar
  22. 22.
    Andrews AF, Roloff DW, Bartlett RH. Use of extracorporeal membrane oxygenator in persistent pulmonary hypertension of the newborn. Clin Perinatol 1984; 11: 729–735.PubMedGoogle Scholar
  23. 23.
    Loe WA Jr, Graves ED III, Ochsner JL, Falterman KW, Arensman RM. Extracorporeal membrane oxygenation for newborn respiratory failure. J Pediatr Surg 1985; 20: 684–688.PubMedGoogle Scholar
  24. 24.
    Short BL, Pearson GD. Neonatal extracorporeal membrane oxygenation: a review. J Intensive Care Med 1986; 1: 47–54.Google Scholar
  25. 25.
    Bartlett RH, Gazzaniga AB, Toomasian J, et al. Extracorporeal membrane oxygenation (ECMO) in neonatal respiratory failure. 100 cases. Ann Surg 1986; 204: 236–245.PubMedGoogle Scholar
  26. 26.
    Redmond CR, Graves ED, Falterman KW, Ochsner JL, Arensman RM. Extracorporeal membrane oxygenation for respiratory and cardiac failure in infants and children. J Thorac Cardiovasc Surg 1987; 93: 199–204.PubMedGoogle Scholar
  27. 27.
    Miller MK, Short BL, Glass P, Lotze A, Anderson KD. Outcome of 100 infants treated with extracorporeal membrane oxygenation (ECMO). Pediatr Res 1987; 21: 369A (Abstract).Google Scholar
  28. 28.
    Glass P, Miller M, Short B. Morbidity for survivors of extracorporeal membrane oxygenation: neurodevelopmental outcome at 1 year of age. Pediatrics 1989; 83: 72–78.Google Scholar
  29. 29.
    Toomasian JM, Snedecor SM, Cornell RG, Cilley RE, Bartlett RH. National experience with extracorporeal membrane oxygenation for newborn respiratory failure. Data from 715 cases. ASAIO Trans 1988; 34: 140–147.PubMedGoogle Scholar
  30. 30.
    Stolar CJ, Snedecor SM, Bartlett RH. Extracorporeal membrane oxygenation and neonatal respiratory failure: experience from the Extracorporeal Life Support Organization. JPediatr Surg 1991; 26: 563–571.Google Scholar
  31. 31.
    Gattinoni L, Pesenti A, Kolobow T, Damia G A new look at therapy of the adult respiratory distress syndrome: motionless lungs. Int Anesthesiol Clin 1983; 21: 97–117.PubMedGoogle Scholar
  32. 32.
    Gattinoni L, Pesenti A, Mascheroni D, et al. Low-frequency positive-pressure ventilation with extracorporeal CO2 removal in severe acute respiratory failure. JAMA 1986; 256: 881–910.PubMedGoogle Scholar
  33. 33.
    Pesenti A, Gattinoni L, Kolobow T, Damia G. Extracorporeal circulation in adult respiratory failure. ASAIO Trans 1988; 34: 43–47.PubMedGoogle Scholar
  34. 34.
    Snider MT, Campbell DB, Kofke WA, et al. Venovenous perfusion of adults and children with severe acute respiratory distress syndrome. The Pennsylvania State University experience from 1982–1987. Trans Am Soc Artif Intern Organs 1988; 34: 1014–1020.Google Scholar
  35. 35.
    Wagner PK, Knoch M, Sangmeister C, Muller E, Lennartz H, Rothmund M. Adult respiratory distress syndrome. Associated morbidity and its surgical treatment. Br J Surg 1990; 77: 1395–1398.PubMedGoogle Scholar
  36. 36.
    Bindslev L, Bohm C, Jolin A, Hambraeus Jonzon K, Olsson P, Ryniak S. Extracorporeal carbon dioxide removal performed with surface-heparinized equipment in patients with ARDS. Acta Anaesthesiol Scand Suppl 1991; 95: 125–130.PubMedGoogle Scholar
  37. 37.
    Bjertnaes LJ, Olafsen K, Nilsen PA, et al. [Extracorporeal membrane oxygenation. A therapeutic alternative in acute heart and/or pulmonary failure?]. Tidsskr Nor Laegeforen 1991; 111: 1477–1480.PubMedGoogle Scholar
  38. 38.
    Lennartz H, Wagner P. [Extracorporeal membrane oxygenation and CO2 elimination]. Langenbecks Arch Chir Suppl ii Verh Dtsch Ges Forsch Chir 1990;P1113–9.:-9.Google Scholar
  39. 39.
    Pesenti A, Kolobow T, Gattinoni L. Extracorporeal respiratory support in the adult. ASAIO Trans 1988; 34: 1006–1008.PubMedGoogle Scholar
  40. 40.
    Sinard JM, Bartlett RH. Extracorporeal life support in critical care medicine. J Crit Care 1990; 5: 265–278.Google Scholar
  41. 41.
    Anderson H III, Steimle C, Shapiro M, et al. Extracorporeal life support for adult cardiorespiratory failure. Surgery 1993; 114: 161–172.PubMedGoogle Scholar
  42. 42.
    Clark GP, Dobson PM, Thickett A, Turner NM. Chickenpox pneumonia, its complications and management. A report of three cases, including the use of extracorporeal membrane oxygenation. Anaesthesia 1991; 46: 376–380.PubMedGoogle Scholar
  43. 43.
    Abdullaev EG, Babyshin VV. [Plasmapheresis with extracorporeal membrane oxygenation of the blood in the treatment of peritonitis]. Klin Khir 1989; 4: 47–48.PubMedGoogle Scholar
  44. 44.
    Gillett DS, Gunning KE, Sawicka EH, Bellingham Ai, Ware RJ. Life threatening sickle chest syndrome treated with extracorporeal membrane oxygenation. Br Med J [Clin Res] 1987; 294: 81–82.Google Scholar
  45. 45.
    King D, Smales C, Arnold AG, Jones OG. Extracorporeal membrane oxygenation as emergency treatment for life-threatening acute severe asthma. Postgrad Med J 1986; 62: 855–857.PubMedGoogle Scholar
  46. 46.
    Pennington DG, Merjavy JP, Codd JE, Swartz MT, Miller LL, Williams GA. Extracorporeal membrane oxygenation for patients with cardiogenic shock. Circulation 1984; 70: 1130–1137.Google Scholar
  47. 47.
    Jurmann MJ, Haverich A, Demertzis S, Schaefers HJ, Wagner TO, Borst HG. Extracorporeal membrane oxygenation as a bridge to lung transplantation. Eur J Cardiothorac Surg 1991; 5: 94–97.PubMedGoogle Scholar
  48. 48.
    Jurmann MJ, Haverich A, Demertzis S, et al. Extracorporeal membrane oxygenation (ECMO): extended indications for artificial support of both heart and lungs. Int J Artif Organs 1991; 14: 771–774.PubMedGoogle Scholar
  49. 49.
    Demertzis S, Haverich A, Ziemer G, et al. Successful lung transplantation for posttraumatic adult respiratory distress syndrome after extracorporeal membrane oxygenation support. J Heart Lung Transplant 1992; 11: 1005–1007.PubMedGoogle Scholar
  50. 50.
    Suchyta MR, Clemmer TP, Orme JF Jr, Morris AH, Elliott CG. Increased survival of ARDS patients with severe hypoxemia (ECMO criteria). Chest 1991; 99: 951–955.PubMedGoogle Scholar
  51. 51.
    Morris AH, Wallace CJ, Menlove RL, et al. Randomized clinical trail of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome. Am J Respir Crit Care Med 1994; 149: 295–305.PubMedGoogle Scholar
  52. 52.
    Trento A, Thompson A, Siewers RD, et al. Extracorporeal membrane oxygenation in children. New trends. J Thorac Cardiovasc Surg 1988; 96: 542–547.PubMedGoogle Scholar
  53. 53.
    Klein MD, Arensman RM, Weber TR, Mottaghy K, Langer R, Nolte SH. Pediatric ECMO. Directions for new developments. ASAIO Trans 1988; 34: 978–985.PubMedGoogle Scholar
  54. 54.
    Frenckner B, Palmer K, Ehren H. [Preliminary experiences show good results. Extracorporeal membrane oxygenation in respiratory insufficiency in children.] Lakartidningen 1990;87: 3505–6, 3511.Google Scholar
  55. 55.
    Anderson HL III, Attorri RJ, Custer JR, Chapman RA, Bartlett RH. Extracorporeal membrane oxygenation for pediatric cardiopulmonary failure. J Thorac Cardiovasc Surg 1990; 99: 1011–1019.PubMedGoogle Scholar
  56. 56.
    Adolph V, Heaton J, Steiner R, Bonis S, Falterman K, Arensman R. Extracorporeal membrane oxygenation for non-neonatal respiratory failure. J Pediatr Surg 1991; 26: 326–330.PubMedGoogle Scholar
  57. 57.
    Extracorporeal membrane oxygenation. Consensus development statement. Australian Association of Paediatric Teaching Centres, in conjunction with the National Health & Medical Research Council and Royal Children’s Hospital, Melbourne. Int J Technol Assess Health Care 1991; 7: 100–105.Google Scholar
  58. 58.
    O’Rourke PP, Stolar CJ, Zwischenberger JB, Snedecor SM, Bartlett RH. Extracorporeal membrane oxygenation: support for overwhelming pulmonary failure in the pediatric population. Collective experience from the extracorporeal life support organization. JPediatr Surg 1993; 28: 523–528.Google Scholar
  59. 59.
    Rivera RA, Butt W, Shann F. Predictors of mortality in children with respiratory failure: possible indications for ECMO. A naesth Intensive Care 1990; 18: 385–389.Google Scholar
  60. 60.
    Timmons OD, Dean JM, Vernon DD. Mortality rates and prognostic variables in children with adult respiratory distress syndrome. J Pediatr 1991; 119: 896–899.PubMedGoogle Scholar
  61. 61.
    Tamburro RF, Bugnitz MC, Stidham GL. Alveolar-arterial oxygen gradient as a predictor of outcome in patients with nonneonatal pediatric respiratory failure. J Pediatr 1991; 119: 935–938.PubMedGoogle Scholar
  62. 62.
    Bartlett RH, Gazzaniga AB. Physiology and pathophysiology of extracorporeal circulation. In: Ionescu MI, Wooler GH, eds. Current Techniques in Extracorporeal Circulation. London: Butterworths; 1980: 1–44.Google Scholar
  63. 63.
    Hirschl RB, Bartlett RH. Extracorporeal membrane oxygenation support in cardiorespiratory failure. Adv Surg 1988; 21: 189–211.PubMedGoogle Scholar
  64. 64.
    Zwischenberger JB, Bartlett RH. Extracorporeal circulation for respiratory or cardiac failure. In: Civetta JM, Taylor RW, Kirby RR, eds. Critical Care. 2nd ed. Philadelphia: Lippincott; 1992: 1809–1820.Google Scholar
  65. 65.
    Bartlett RH. Extracorporeal life support for cardiopulmonary failure. Curr Probl Surg 1990; 27: 621–705.PubMedGoogle Scholar
  66. 66.
    Bui KC, LaClair P, Vanderkerhove J, Bartlett RH. ECMO in premature infants. Review of factors associated with mortality. ASAIO Trans 1991; 37: 54–59.PubMedGoogle Scholar
  67. 67.
    Bartlett RH, Morris AH, Fairley HB, Hirsch R, O’Connor N, Pantoppidan H. A prospective study of acute hypoxic respiratory failure. Chest 1986; 89: 684–689.PubMedGoogle Scholar
  68. 68.
    Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 1985; 132: 485–489.PubMedGoogle Scholar
  69. 69.
    Beck R, Anderson KD, Pearson GD, Cronin J, Miller MK, Short BL. Criteria for extracorporeal membrane oxygenation in a population of infants with persistent pulmonary hypertension of the newborn. J Pediatr Surg 1986; 21: 297–302.PubMedGoogle Scholar
  70. 70.
    Hallman M, Merrit A, Jarvenpaa A, et al. Exogenous human surfactant for treatment of severe respiratory distress syndrome: a randomized prospective clinical trial. J Pediatr 1985; 106: 963–969.PubMedGoogle Scholar
  71. 71.
    Gattinoni L, Pesenti A, Caspani ML, et al. The role of total static lung compliance in the management of severe ARDS unresponsive to conventional treatment. Intensive Care Med 1984; 10: 121–126.PubMedGoogle Scholar
  72. 72.
    Cole CH, Jillson E, Kessler D. ECMO: regional evaluation of need and applicability of selection criteria. Am J Dis Child 1988; 142: 1320–1324.PubMedGoogle Scholar
  73. 73.
    Dworetz AR, Moya FR, Sabo B, Gladstone I, Gross I. Survival of infants with persistent pulmonary hypertension without extracorporeal membrane oxygenation. Pediatrics 1989; 84: 1–6.PubMedGoogle Scholar
  74. 74.
    Extracorporeal Life Support Organization. ECMO Registry Report. Ann Arbor, MI: University of Michigan; 1993.Google Scholar
  75. 75.
    Bartlett RH, Roloff DW, Cornell RG, Andrews AF, Dillon PW, Zwischenberger JB. Extracorporeal circulation in neonatal respiratory failure: a prospective randomized study. Pediatrics 1985; 76: 479–487.PubMedGoogle Scholar
  76. 76.
    Ormazabal MA, Kirkpatrick BV, Mueller DG. Alterations of A-a DO2 in response to tolazoline as a predictor of outcome in neonates with persistent pulmonary hypertension. Pediatr Res 1980;14:607. Abstract.Google Scholar
  77. 77.
    Krummel TM, Greenfield LJ, Kirkpatrick BV, et al. Alveolar-arterial oxygen gradients versus the Neonatal Pulmonary Insufficiency Index for prediction of mortality in ECMO candidates. J Pediatr Surg 1984; 19: 380–384.PubMedGoogle Scholar
  78. 78.
    Marsh TD, Wilkerson SA, Cook LN. Extracorporeal membrane oxygenation selection criteria: partial pressure of arterial oxygen versus alveolar-arterial oxygen gradient. Pediatrics 1988; 82: 162–166.PubMedGoogle Scholar
  79. 79.
    Wung J, James LS, Kilchevsky E, James E. Management of infants with severe respiratory failure and persistence of the fetal circulation, without hyperventilation. Pediatrics 1985; 76: 488–494.PubMedGoogle Scholar
  80. 80.
    Hageman JR, Dusik J, Keuler H, Bregman J, Gardner TH. Outcome of persistent pulmonary hypertension in relation to severity of presentation. Am JDis Child 1988; 142: 293–296.Google Scholar
  81. 81.
    Ortega M, Ramos AD, Platzker ACG, Atkinson JB, Bowman CM. Early prediction of ultimate outcome in newborn infants with severe respiratory failure. J Pediatr 1988; 113: 744–747.PubMedGoogle Scholar
  82. 82.
    Nading JH. Historical controls for extracorporeal membrane oxygenation in neonates. Crit Care Med 1989; 17: 423–425.PubMedGoogle Scholar
  83. 83.
    Ware JH, Epstein MF. Commentary: extracorporeal circulation in neonatal respiratory failure: a prospective randomized study. Pediatrics 1985; 76: 849–851.PubMedGoogle Scholar
  84. 84.
    ORourke PP, Crone RK, Vacanti JP, et al. Extracorporeal membrane oxygenation and conventional medical therapy in neonates with persistent pulmonary hypertension of the newborn: a prospective randomized study. Pediatrics 1989; 84: 957–963.Google Scholar
  85. 85.
    Watson JW, Brown DM, Lally KP, Null D, Clark R. Complications of extracorporeal membrane oxygenation in neonates. South Med J 1990; 83: 1262–1265.PubMedGoogle Scholar
  86. 86.
    Donn SM. ECMO indications and complications. Hosp Pract[Off]1990;25:143–146,149–150.Google Scholar
  87. 87.
    Bowerman RA, Zwischenberger JB, Andrews AF, Bartlett RH. Cranial sonography of the infant treated with extracorporeal membrane oxygenation. AJR 1985; 145: 161–166.PubMedGoogle Scholar
  88. 88.
    Cilley RE, Zwischenberger JB, Andrews AF, Bowerman RA, Roloff DW, Bartlett RH. Intracranial hemorrhage during extracorporeal membrane oxygenation in neonates. Pediatrics 1986; 78: 699–704.PubMedGoogle Scholar
  89. 89.
    Taylor GA, Catena LM, Garin DB, Miller MK, Short BL. Intracranial flow patterns in infants undergoing extracorporeal membrane oxygenation: preliminary observations with Doppler US. Radiology 1987; 165: 671–674.PubMedGoogle Scholar
  90. 90.
    Taylor GA, Fitz CR, Miller MK, Garin DB, Catena LM, Short BL. Intracranial abnormalities in infants treated with extracorporeal membrane oxygenation: imaging with US and CT. Radiology 1987; 165: 675–678.PubMedGoogle Scholar
  91. 91.
    Taylor GA, Glass P, Fitz CR, Miller MK. Neurologic status in infants treated with extracorporeal membrane oxygenation: correlation of imaging findings with developmental outcome. Radiology 1987; 165: 679–682.PubMedGoogle Scholar
  92. 92.
    Pearlman JM, Altman DI, Powers WS, Volpe JJ. Cerebral injury and regional cerebral blood flow in newborn infants undergoing extracorporeal membrane oxygenation. Ann Neurol 1987;22:421. Abstract.Google Scholar
  93. 93.
    Schumacher RE, Barks JD, Johnston MV, et al. Right-sided brain lesions in infants following extracorporeal membrane oxygenation. Pediatrics 1988; 82: 155–161.PubMedGoogle Scholar
  94. 94.
    Campbell LR, Bunyapen C, Holmes GL, Howell CG Jr, Kanto WP Jr. Right common carotid artery ligation in extracorporeal membrane oxygenation. J Pediatr 1988; 113: 110–113.PubMedGoogle Scholar
  95. 95.
    Mitchell DG, Merton D, Desai H, et al. Neonatal brain: color Doppler imaging. Part II. Altered flow patterns from extracorporeal membrane oxygenation. Radiology 1988; 167: 307–310.PubMedGoogle Scholar
  96. 96.
    Taylor GA, Short BL, Glass P, Ichord R. Cerebral hemodynamics in infants undergoing extracorporeal membrane oxygenation: further observations. Radiology 1988; 168: 163–167.PubMedGoogle Scholar
  97. 97.
    Luisiri A, Graviss ER, Weber T, et al. Neurosonographic changes in newborns treated with extracorporeal membrane oxygenation. J Ultrasound Med 1988; 7: 429–438.PubMedGoogle Scholar
  98. 98.
    Slovis TL, Sell LL, Bedard MP, Klein MD. Ultrasonographic findings (CNS, thorax, abdomen) in infants undergoing extracorporeal membrane oxygenation therapy. Pediatr Radiol 1988;18:112–117.PubMedGoogle Scholar
  99. 99.
    Raju TN, Kim SY, Meller JL, Srinivasan G, Ghai V, Reyes H. Circle of Willis blood velocity and flow direction after common carotid artery ligation for neonatal extracorporeal membrane oxygenation. Pediatrics 1989; 83: 343–347.PubMedGoogle Scholar
  100. 100.
    Taylor GA, Fitz CR, Kapur S, Short BL. Cerebrovascular accidents in neonates treated with extracorporeal membrane oxygenation: sonographic-pathologic correlation. AJR 1989; 153: 355–361.PubMedGoogle Scholar
  101. 101.
    Lewin JS, Masaryk TJ, Modic MT, Ross JS, Stork EK, Wiznitzer M. Extracorporeal membrane oxygenation in infants: angiographic and parenchymal evaluation of the brain with MR imaging Radiology 1989; 173: 361–365.PubMedGoogle Scholar
  102. 102.
    Short BL. Brain lesions and extracorporeal membrane oxygenation. Pediatrics 1989; 83: 634–635.PubMedGoogle Scholar
  103. 103.
    Sell LL, Cullen ML, Whittlesey GC, et al. Hemorrhagic complications during extracorporeal membrane oxygenation: prevention and treatment. J Pediatr Surg 1986; 21: 1087–1091.PubMedGoogle Scholar
  104. 104.
    Anderson HL III, Cilley RE, Zwischenberger JB, Bartlett RH. Thrombocytopenia in neonates after extracorporeal membrane oxygenation. ASAIO Trans 1986; 32: 534–537.PubMedGoogle Scholar
  105. 105.
    Zwischenberger JB, Cilley RE, Hirschl RB, Heiss KF, Conti VR, Bartlett RH. Life-threatening intrathoracic complications during treatment with extracorporeal membrane oxygenation. JPediatr Surg 1988; 23: 599–604.Google Scholar
  106. 106.
    Zach TL, Steinhorn RH, Georgieff MK, Mills MM, Green TP. Leukopenia associated with extracorporeal membrane oxygenation in newborn infants. J Pediatr 1990; 116: 440–444.PubMedGoogle Scholar
  107. 107.
    Steinhorn RH, Isham Schopf B, Smith C, Green TP. Hemolysis during long-term extracorporeal membrane oxygenation. J Pediatr 1989; 115: 625–630.PubMedGoogle Scholar
  108. 108.
    Pyles LA, Einzig S, Stejskal EA, et al. Myocardial stunning during extracorporeal membrane oxygenation in newborn infants. Crit Care Med 1990;18:5244. Abstract.Google Scholar
  109. 109.
    Martin GR, Short BL, Abbott C, O’Brien AM. Cardiac stun in infants undergoing extracorporeal membrane oxygenation. J Thorac Cardiovasc Surg 1991; 101: 607–611.PubMedGoogle Scholar
  110. 110.
    Cater G, Lotze A, Miller M, Short B. Stunned myocardium in an infant treated with extracorporeal membrane oxygenation. JPediatrSurg 1988; 23: 1011–1013.Google Scholar
  111. 111.
    Fink SM, Bockman DE, Howell CG, Falls DG, Kanto WP Jr. Bypass circuits as the source of thromboemboli during extracorporeal membrane oxygenation. J Pediatr 1989; 115: 621–624.PubMedGoogle Scholar
  112. 112.
    Vogler C, Sotelo Avila C, Lagunoff D, Braun P, Schreifels JA, Weber T. Aluminum-containing emboli in infants treated with extracorporeal membrane oxygenation. N Engl JMed 1988; 319: 75–79.Google Scholar
  113. 113.
    Shneider B, Mailer E, VanMarter L, O’Rourke PP. Cholestasis in infants supported with extracorporeal membrane oxygenation. J Pediatr 1989; 115: 462–465.PubMedGoogle Scholar
  114. 114.
    Shneider B, Schena J, Truog R, Jacobson M, Kevy S. Exposure to di(2-ethylhexyl)phthalate in infants receiving extracorporeal membrane oxygenation. N Engl J Med 1989; 320: 1563.PubMedGoogle Scholar
  115. 115.
    Sell LL, Cullen ML, Lerner GR, Whittlesey GC, Shanley CJ, Klein MD. Hypertension during extracorporeal membrane oxygenation: cause, effect, and management. Surgery 1987; 102: 724–730.PubMedGoogle Scholar
  116. 116.
    Boedy RF, Goldberg AK, Howell CG Jr, Hulse E, Edwards EG, Kanto WP Jr. Incidence of hypertension in infants on extracorporeal membrane oxygenation. J Pediatr Surg 1990; 25: 258–261.PubMedGoogle Scholar
  117. 117.
    Schumacher RE, Weinfeld IJ, Bartlett RH. Neonatal vocal cord paralysis following extracorporeal membrane oxygenation. Pediatrics 1989; 84: 793–796.PubMedGoogle Scholar
  118. 118.
    Schumacher RE, Spak C, Kileny PR. Asymmetric brain stem auditory evoked responses in infants treated with extracorporeal membrane oxygenation. Ear Hear 1990; 11: 359–362.PubMedGoogle Scholar
  119. 119.
    Lott IT, McPherson D, Towne B, Johnson D, Starr A. Long-term neurophysiologic outcome after neonatal extracorporeal membrane oxygenation. JPediatr 1990; 116: 343–349.Google Scholar
  120. 120.
    Krummel TM, Greenfield LJ, Kirkpatrick BV, et al. The early evaluation of survivors after extracorporeal membrane oxygenation for neonatal pulmonary failure. JPediatr Surg 1984; 19: 585–590.Google Scholar
  121. 121.
    Towne BH, Lott IT, Hicks DA, Healey T. Long-term follow-up of infants and children treated with extracorporeal membrane oxygenation (ECMO): a preliminary report. J Pediatr Surg 1985; 20: 410–414.PubMedGoogle Scholar
  122. 122.
    Andrews AF, Nixon CA, Cilley RE, Roloff DW, Bartlett RH. One-to three-year outcome for 14 neonatal survivors of extracorporeal membrane oxygenation. Pediatrics 1986; 78: 692–698.PubMedGoogle Scholar
  123. 123.
    Adolph V, Ekelund C, Smith C, Starrett A, Falterman K, Arensman R. Developmental outcome of neonates treated with extracorporeal membrane oxygenation. JPediatr Surg 1990; 25: 43–46.Google Scholar
  124. 124.
    Schumacher RE, Palmer TW, Roloff DW, LaClaire PA, Bartlett RH. Follow-up of infants treated with extracorporeal membrane oxygenation for newborn respiratory failure. Pediatrics 1991; 87: 451–457.PubMedGoogle Scholar
  125. 125.
    Garg M, Kurzner SI, Bautista DB, et al. Pulmonary sequelae at six months following extracorporeal membrane oxygenation. Chest 1992; 101: 1086–1090.PubMedGoogle Scholar
  126. 126.
    Griffin MP, Minifee PK, Landry SH, Allison PL, Swischuk LE, Zwischenberger JB. Neurodevelopmental outcome in neonates after extracorporeal membrane oxygenation: cranial magnetic resonance imaging and ultrasonography correlation. JPediatr Surg 1992; 27: 33–35.Google Scholar
  127. 127.
    Paccioretti DC, Haluschak MM, Finer NN, Robertson CM, Pain KS, Hagler M. Auditory brain-stem responses in neonates receiving extracorporeal membrane oxygenation. J Pediatr 1992; 120: 464–467.PubMedGoogle Scholar
  128. 128.
    Park CH, Spitzer AR, Desai HJ, Zhang JJ, Graziani LJ. Brain SPECT in neonates following extracorporeal membrane oxygenation: evaluation of technique and preliminary results. JNucl Med 1992; 33: 1943–1948.Google Scholar
  129. 129.
    Revenis ME, Glass P, Short BL. Mortality and morbidity rates among lower birth weight infants (2000 to 2500 grams) treated with extracorporeal membrane oxygenation. JPediatr 1992; 121: 452–458.Google Scholar
  130. 130.
    Schwendeman CA, Clark RH, Yoder BA, Null DM Jr, Gerstmann DR, deLemos RA. Frequency of chronic lung disease in infants with severe respiratory failure treated with high-frequency ventilation and/or extracorporeal membrane oxygenation. Crit Care Med 1992; 20: 372–377.PubMedGoogle Scholar
  131. 131.
    Streletz LJ, Bej MD, Graziani LJ, et al. Utility of serial EEGs in neonates during extracorporeal membrane oxygenation. Pediatr Neurol 1992; 8: 190–196.PubMedGoogle Scholar
  132. 132.
    Flusser H, Dodge NN, Engle WE, Garg BP, West KW. Neurodevelopmental outcome and respiratory morbidity for extracorporeal membrane oxygenation survivors at 1 year of age. J Perinatol 1993; 13: 266–271.Google Scholar
  133. 133.
    Korinthenberg R, Kachel W, Koelfen W, Schultz C, Varnholt V. Neurological findings in newborn infants after extracorporeal membrane oxygenation, with special reference to the EEG. Dev Med Child Neurol 1993; 35: 249–257.PubMedGoogle Scholar
  134. 134.
    Weber TR, Westfall SH, Sotelo C, Vogler CA, Tracy T Jr. A clinical-pathological study of nonsurvivors of newborn ECMO. JPediatr Surg 1993; 28: 135–137.Google Scholar
  135. 135.
    Brett C, Dekle M, Leonard CH, et al. Developmental follow-up of hyperventilated neonates: preliminary observations. Pediatrics 1981; 68: 588–591.PubMedGoogle Scholar
  136. 136.
    Bernbaum JC, Russell P, Sheridan PH, Gewitz MH, Fox WW, Peckham GJ. Long-term follow-up of newborns with persistent pulmonary hypertension. Crit Care Med 1984; 12: 579–583.PubMedGoogle Scholar
  137. 137.
    Ferrara B, Johnson DE, Chang PN, Thompson TR. Efficacy and neurologic outcome of profound hypocapneic alkalosis for the treatment of persistent pulmonary hypertension in infancy. J Pediatr 1984; 105: 457–461.PubMedGoogle Scholar
  138. 138.
    Sell EJ, Gaines JA, Gluckman C, Williams E. Persistent fetal circulation. Neurodevelopmental outcome. Am J Dis Child 1985; 139: 25–28.PubMedGoogle Scholar
  139. 139.
    Bifano EM, Pfannenstiel A. Duration of hyperventilation and outcome in infants with persistent pulmonary hyptertension. Pediatrics 1988; 81: 657–661.PubMedGoogle Scholar
  140. 140.
    Ballard RA, Leonard CH. Developmental follow-up of infants with persistent pulmonary hypertension of the newborn. Clin Perinato11984; 11: 737–744.Google Scholar
  141. 141.
    Leavitt AM, Watchko JF, Bennett FC, Folsom RC. Neurodevelopmental outcome following persistent pulmonary hypertension of the neonate. J Perinatol 1987; 7: 288–291.PubMedGoogle Scholar
  142. 142.
    John E, Roberts V, Burnard ED. Persistent pulmonary hypertension of the newborn treated with hyperventilation: clinical features and outcome. Aust Paediatr J 1988; 24: 357–361.PubMedGoogle Scholar
  143. 143.
    Hendricks-Munoz KD, Walton JP. Hearing loss in infants with persistent fetal circulation. Pediatrics 1988; 81: 650–656.PubMedGoogle Scholar
  144. 144.
    Oelberg DG, Temple DM, Haskins KS, Bigelow RH, Adcock EW. Intracranial hemorrhage in term or near-term newborns with persistent pulmonary hypertension. Clin Pediatr 1988; 27: 14–17.Google Scholar
  145. 145.
    Klesh KW, Murphy TF, Scher MS, Buchanan DE, Maxwell EP, Guthrie RD. Cerebral infarction in persistent pulmonary hypertension of the newborn. Am J Dis Child 1987; 141: 852–587.PubMedGoogle Scholar
  146. 146.
    Martin GR, Short BL. Doppler echocardiographic evaluation of cardiac performance in infants on prolonged extracorporeal membrane oxygenation. Am J Cardiol 1988; 62: 929–934.PubMedGoogle Scholar
  147. 147.
    Walther FJ, van de Bor M, Gangitano ES, Snyder JR. Left and right ventricular output in newborn infants undergoing extracorporeal membrane oxygenation. Crit Care Med 1990; 18: 148–151.PubMedGoogle Scholar
  148. 148.
    Taylor GA, Martin GR, Short BL. Cardiac determinants of cerebral blood flow during extracorporeal membrane oxygenation. Invest Radiol 1989; 24: 511–516.PubMedGoogle Scholar
  149. 149.
    Martin GR, Chauvin L, Short BL. Effects of hydralazine on cardiac performance in infants receiving extracorporeal membrane oxygenation. J Pediatr 1991; 118: 944–948.PubMedGoogle Scholar
  150. 150.
    Karr SS, Martin GR, Short BL. Cardiac performance in infants referred for extracorporeal membrane oxygenation. J Pediatr 1991; 118: 437–442.PubMedGoogle Scholar
  151. 151.
    Kimball TR, Daniels SR, Weiss RG, et al. Changes in cardiac function during extracorporeal membrane oxygenation for persistent pulmonary hypertension in the newborn infant. JPediatr 1991; 118: 431–436.Google Scholar
  152. 152.
    Kinsella JP, McCurnin DC, Clark RH, Lally KP, Null DM Jr. Cardiac performance in ECMO candidates: echocardiographic predictors for ECMO. JPediatr Surg 1992; 27: 44–47.Google Scholar
  153. 153.
    Bartlett RH, Gazzaniga AB, Wetmore NE, Rucker R, Huxtable RF. Extracorporeal membrane oxygenation (ECMO) in the treatment of cardiac and respiratory failure in chil- dren. Trans Am Soc Artif Intern Organs 1980; 26: 578–581.PubMedGoogle Scholar
  154. 154.
    Morio S, Yoshino Y, Yorozu H, et al. [Prolonged extracorporeal membrane oxygenation for acute cardiac failure (author’s transl)]. Kyobu Geka 1980; 33: 296–300.PubMedGoogle Scholar
  155. 155.
    Cullen M, Splittgerber F, Sweezer W, Hakimi M, Arciniegas E, Klein M. Pulmonary hypertension postventricular septal defect repair treated by extracorporeal membrane oxygenation. J Pediatr Surg 1986; 21: 675–677.PubMedGoogle Scholar
  156. 156.
    Kanter KR, Pennington G, Weber TR, Zambie MA, Braun P, Martychenko V. Extracorporeal membrane oxygenation for postoperative cardiac support in children. J Thorac Cardiovasc Surg 1987; 93: 27–35.PubMedGoogle Scholar
  157. 157.
    Rogers AJ, Trento A, Siewers RD, et al. Extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock in children. Ann Thorac Surg 1989; 47: 903–906.PubMedGoogle Scholar
  158. 158.
    Weinhaus L, Canter C, Noetzel M, McAlister W, Spray TL. Extracorporeal membrane oxygenation for circulatory support after repair of congenital heart defects. Ann Thorac Surg 1989; 48: 206–212.PubMedGoogle Scholar
  159. 159.
    Klein MD, Shaheen KW, Whittlesey GC, Pinsky WW, Arciniegas E. Extracorporeal membrane oxygenation for the circulatory support of chidlren after repair of congenital heart disease. J Thorac Cardiovasc Surg 1990; 100: 498–505.PubMedGoogle Scholar
  160. 160.
    Eugene J, McColgan SJ, Moore Jeffries EW, Ott RA, Hai-duc NJ, Roohk HV. Cardiac assist by extracorporeal membrane oxygenation with in-line left ventricular venting. Trans Am Soc Artif Intern Organs 1984; 30: 99–102.PubMedGoogle Scholar
  161. 161.
    Eugene J, Ott RA, McColgan SJ, Roohk HV. Vented cardiac assistance: ECMO versus left heart bypass for acute left ventricular failure. ASAIO Trans 1986; 32: 538–541.PubMedGoogle Scholar
  162. 162.
    Kolobow T, Rossi F, Borelli M, Foti G. Long-term closed chest partial and total cardiopulmonary bypass by peripheral cannulation for severe right and/or left ventricular failure, including ventricular fibrillation. The use of a per-cutaneous spring in the pulmonary artery position to decompress the left heart. ASAIO Trans 1988; 34: 485–489.PubMedGoogle Scholar
  163. 163.
    Rossi F, Kolobow T, Foti G, Borelli M, Mandava S. Longterm cardiopulmonary bypass by peripheral cannulation in a model of total heart failure. The decompression of the left heart through a percutaneous helical spring positioned within the lumen of the tricuspid and pulmonary artery valves. J Thorac Cardiovasc Surg 1990; 100: 914–920.PubMedGoogle Scholar
  164. 164.
    Secker Walker JS, Edmonds JF, Spratt EH, Conn AW. The source of coronary perfusion during partial bypass for extracorporeal membrane oxygenation (ECMO). Ann Thorac Surg 1976; 21: 138–143.PubMedGoogle Scholar
  165. 165.
    Nowlen TT, Salley SO, Whittlesey GC, Kundu SK, Maniaci NA, Henry RL, Klein MD. Regional blood flow distribution during extracorporeal membrane oxygenation in rabbits. J Thorac Cardiovasc Surg 1989; 98: 1138–1143.PubMedGoogle Scholar
  166. 166.
    Smith HG, Whittlesey GC, Kundu SK, et al. Regional blood flow during extracorporeal membrane oxygenationin lambs. ASAIO Trans 1989; 35: 657–660.PubMedGoogle Scholar
  167. 167.
    Gerstmann DR, Nose K, Kinsella JP, Cornish JD. Left carotid artery (LCA) and coronary (CA) arterial flow partitioning during neonatal ECMO. Pediatr Res 1989;25:37A. Abstract.Google Scholar
  168. 168.
    Kinsella JP, Gerstmann DR, Rosenberg AA. The effect of extracorporeal membrane oxygenation on coronary perfusion and regional blood flow distribution. Pediatr Res 1992; 31: 80–84.PubMedGoogle Scholar
  169. 169.
    Dickson ME, Hirthler MA, Simoni J, Bradley CA, Goldthorn JF. Stunned myocardium during extracorporeal membrane oxygenation. Am J Surg 1990; 160: 644–646.PubMedGoogle Scholar
  170. 170.
    Rosenberg EM, Cook LN. Electromechanical dissociation in newborns treated with extracorporeal membrane oxygenation: an extreme form of cardiac stun syndrome. Crit Care Med 1991; 19: 780–784.PubMedGoogle Scholar
  171. 171.
    Pennington DG, McBride LR, Kanter KR, et al. Bridging to heart transplantation with circulatory support devices. J Heart Transplant 1989; 8: 116–123.PubMedGoogle Scholar
  172. 172.
    Delius RE, Zwischenberger JB, Cilley R, et al. Prolonged extracorporeal life support of pediatric and adolescent cardiac transplant patients. Ann Thorac Surg 1990; 50: 791–795.PubMedGoogle Scholar
  173. 173.
    Galantowicz ME, Stolar CJ. Extracorporeal membrane oxygenation for perioperative support in pediatric heart transplantation. J Thorac Cardiovasc Surg 1991; 102: 148–151.PubMedGoogle Scholar
  174. 174.
    Reedy JE, Swartz MT, Raithel SC, Szukalski EA, Pennington DG. Mechanical cardiopulmonary support for refractory cardiogenic shock. Heart Lung 1990; 19: 514–523.PubMedGoogle Scholar
  175. 175.
    Pearson GD, Short BL. An economic analysis of extracorporeal membrane oxygenation. Jlntensive Care Med 1987; 2: 116–120.Google Scholar
  176. 176.
    Adolph V, Bonis S, Falterman K, Arensman R. Carotid artery repair after pediatric extracorporeal membrane oxygenation. J Pediatr Surg 1990; 25: 867–869.PubMedGoogle Scholar
  177. 177.
    Karl TR, Iyer KS, Sano S, Mee RB. Infant ECMO cannulation technique allowing preservation of carotid and jugular vessels. Ann Thorac Surg 1990; 50: 488–489.PubMedGoogle Scholar
  178. 178.
    Crombleholme TM, Adzick NS, deLorimier AA, Longaker MT, Harrison MR, Charlton VE. Carotid artery reconstruction following extracorporeal membrane oxygenation. Am J Dis Child 1990; 144: 872–874.PubMedGoogle Scholar
  179. 179.
    Spector ML, Wiznitzer M, Walsh Sukys MC, Stork EK. Carotid reconstruction in the neonate following ECMO. J Pediatr Surg 1991; 26: 357–359.PubMedGoogle Scholar
  180. 180.
    Moulton SL, Lynch FP, Cornish JD, Bejar RF, Simko AJ, Krous HF. Carotid artery reconstruction following neonatal extracorporeal membrane oxygenation. J Pediatr Surg 1991; 26: 794–799.PubMedGoogle Scholar
  181. 181.
    DeAngelis GA, Mitchell DG, Merton DA, et al. Right common carotid artery reconstruction in neonates after extracorporeal membrane oxygenation: color Doppler imaging. Radiology 1992; 182: 521–525.PubMedGoogle Scholar
  182. 182.
    Schaupp W, Brands W, Wirth H, Kachel W, Lasch P, Schmitt B. Reconstruction of the arteria carotis communis in newborn following extracorporeal membrane oxygenation (ECMO). Eur JPediatr Surg 1992; 2: 78–80.Google Scholar
  183. 183.
    Solca M, Kolobow T, Huang HH, Chen V, Buckhold DK, Pierce JE. Respiratory distress syndrome in immature lambs. Prevention through antenatal accelerated conditioning of the lung. Am Rev Respir Dis 1984; 129: 979–984.PubMedGoogle Scholar
  184. 184.
    Andrews AF, Zwischenberger JB, Cilley RE, Drake KL. Venovenous extracorporeal membrane oxygenation (ECMO) using a double-lumen cannula. Artif Organs 1987; 11: 265–268.PubMedGoogle Scholar
  185. 185.
    Zwischenberger JB, Toomasian JM, Drake K, Andrews AF, Kolobow T, Bartlett RH. Total respiratory support with single cannula venovenous ECMO: double lumen continuous flow vs. single lumen tidal flow. Trans Am Soc Artif Intern Organs 1985; 31: 610–615.PubMedGoogle Scholar
  186. 186.
    Otsu T, Merz SI, Hultquist KA. Laboratory evaluation of a double lumen catheter for venovenous neonatal ECMO ASAIO Trans 1989; 35: 647–650.PubMedGoogle Scholar
  187. 187.
    Anderson HL III, Otsu T, Chapman RA, Bartlett RH. Venovenous extracorporeal life support in neonates using a double lumen catheter. ASAIO Trans 1989; 35: 650–653.PubMedGoogle Scholar
  188. 188.
    Anderson HL III, Snedecor SM, Otsu T, Bartlett RH. Multicenter comparison of conventinal venoarterial access versus venovenous double-lumen catheter access in new born infants undergoing extracorporeal membrane oxygenation. JPediatr Surg 1993; 28: 530–534.Google Scholar
  189. 189.
    Delius R, Anderson H III, Schumacher R, et al. Venovenous compares favorably with venoarterial access for extra corporeal membrane oxygenation in neonatal respiratory failure. J Thorac Cardiovasc Surg 1993; 106: 329–338.PubMedGoogle Scholar
  190. 190.
    Cornish JD, Heiss KF, Clark RH, Strieper MJ, Boecler B, Kesser K. Efficacy of venovenous extracorporeal mem brane oxygenation for neonates with respiratory and circu latory compromise. J Pediatr 1993; 122: 105–109.PubMedGoogle Scholar
  191. 191.
    Bindslev L, Eklund J, Norlander O, et al. Treatment of acute respiratory failure by extracorporeal carbon dioxide elimination performed with a surface heparinized artificial lung. Anesthesiology 1987; 67: 117–120.PubMedGoogle Scholar
  192. 192.
    Peters J, Radermacher P, Kuntz ME, et al. Extracorporeal CO2-removal with a heparin coated artificial lung. Intensive Care Med 1988; 14: 578–584.PubMedGoogle Scholar
  193. 193.
    Marcolin R, Cugno M, Pesenti A, et al. Extracorporeal cir culation in sheep with normal bleeding time using a surface. heparinized circuit. Trans Am Soc Artif Intern Organs 1991; 37: 584–587.Google Scholar
  194. 194.
    van der Hulst VPM, Grundeman PF, Moulijn AC, Rutten PJJM, Klopper PJ. Long-term extracorporeal blood by-pass in dogs at low flows without systemic heparinization. Heparin-coated versus uncoated circuits. Trans Am Soc Artif Intern Organs 1991; 37: 577–583.Google Scholar
  195. 195.
    Bindslev L. Adult ECMO performed with surface heparinized equipment. ASAIO Trans 1988; 34: 1009–1013.PubMedGoogle Scholar
  196. 196.
    Cornish JD, Gerstmann DR, Clark RH, Carter JM, Null DM Jr, deLemos RA. Extracorporeal membrane oxygenation and high-frequency oscillatory ventilation: potential therapeutic relationships. Crit Care Med 1987; 15: 831–834.PubMedGoogle Scholar
  197. 197.
    Carter JM, Gerstmann DR, Clark RH, et al. Highfrequency oscillatory ventilation and extracorporeal membrane oxygenation for the treatment of acute neonatal respiratory failure. Pediatrics 1990; 85: 159–164.PubMedGoogle Scholar
  198. 198.
    Keszler M, Subramanian KN, Smith YA, et al. Pulmonary management during extracorporeal membrane oxygenation. Crit Care Med 1989; 17: 495–500.PubMedGoogle Scholar
  199. 199.
    Keszler M, Ryckman FC, McDonald JV Jr, et al. A prospective, multicenter, randomized study of high versus low positive end-expiratory pressure during extracorporeal membrane oxygenation. J Pediatr 1992; 120: 107–113.PubMedGoogle Scholar

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© Springer-Verlag New York Inc. 1995

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  • J. Devn Cornish

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