Hookworms: Necator americanus (Stiles 1902) and Ancylostoma duodenale (Dubini 1843)

  • Dickson D. Despommier
  • Robert W. Gwadz
  • Peter J. Hotez


Two major species of hookworm infect humans: Necator americanus (New World hookworm) and Ancylostoma duodenale (Old World hookworm). Adults of both species inhabit the small intestine and feed on intestinal mucosa and blood.


Clay Pneumonia Anemia Dermatitis Nism 


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  1. 1.
    Prociv P, Croese J: Human eosinophilic enteritis caused by dog hookworm, Ancylostoma caninum. Lancet 335: 1299–1302, 1990PubMedCrossRefGoogle Scholar
  2. 2.
    Stoll NR: This wormy world. J Parasitol 33: 1–18, 1947PubMedCrossRefGoogle Scholar
  3. 3.
    Stiles CW: A new species of hookworm (Uncinaria americana) parasitic in man. Am Med 3: 777–778, 1902Google Scholar
  4. 4.
    Dubini A: Nuovo verme intestinale umano Ancylostoma duodenale, constitutente un sesto genere dei nematoidei proprii dell’uomo. Ann Univ Med Milano 106: 5–13, 1843Google Scholar
  5. 5.
    Hoagland KE, Schad GA: Necator americanus and Ancylostoma duodenale: life history parameters and epidemiological implications of two sympatric hookworms on humans. Exp Parasitol 44: 36–49, 1978PubMedCrossRefGoogle Scholar
  6. 6.
    Hotez PJ, Hagerty J, Hawdon J, et al: Infective Ancylostoma hookworm larval metalloproteases and their functions in tissue invasion and ecdysis. Infect Immun 58: 3883–3892, 1990PubMedGoogle Scholar
  7. 7.
    Hotez PJ, Narasimhan S, Haggerty J, et al: Hyaluronidase from infective Ancylostoma larvae and its possible function as a virulence factor in invasion and in cutaneous larva migrans. Infect Immun 60: 1018–1023, 1992PubMedGoogle Scholar
  8. 8.
    Kendrick JF: The length of life and rate of loss of hookworm. Ancylostoma duodenale and Necator americanus. Am J Trop Med Hyg 14: 363–379, 1934Google Scholar
  9. 9.
    Plamer ED: Course of egg output over a 15 year period in a case of experimentally induced necatoriasis americanus. Am J Trop Med Hyg 4: 756–757, 1955Google Scholar
  10. 10.
    Schad GA, Chowdhury AB, Dean CG, et al: Arrested development in human hookworm infections: an adaptation to a seasonally unfavorable external environment. Science 180: 502–504, 1973PubMedCrossRefGoogle Scholar
  11. 11.
    Sen-Hai Y, Wei-Xia S: Hookworm infection and disease in China, pp 44–54. In Schad GA, Warren KS (eds) Hookworm Disease. Current Status and New Directions. Taylor & Francis, London, 1990Google Scholar
  12. 12.
    Hotez P, Hawdon J, Schad GA: Hookworm larval infectivity, arrest and amphiparatensis: the Caenorhabditis elegans DAF-C paradigm. Parasitol Today 9: 23–26, 1993PubMedCrossRefGoogle Scholar
  13. 13.
    Cappello M, Clyne L, McPhedran P, Hotez P: Ancylostoma factor Xa inhibitor: partial purification and its identification as a major hookworm-derived anticoagulant in vitro. J Infect Dis 167: 1474–1477, 1993PubMedCrossRefGoogle Scholar
  14. 14.
    Roche M, Layrisse M: The nature and causes of “hookworm anemia.” Am J Trop Med Hyg 15: 1031–1102, 1966Google Scholar
  15. 15.
    Pritchard DI, Quinnell RJ, Slater AFG, et al: Epidemiology and immunology of Necator americanus infection in a community in Papua New Guinea: humoral responses to excretory-secretory and cuticular collagen antigens. Parasitology 100: 317–326, 1990PubMedCrossRefGoogle Scholar
  16. 16.
    Kumar S, Pritchard DI: Skin penetration by ensheathed third-stage infective larvae of Necator americanus, and the host’s immune response to larval antigens. Int J Parasitol 22: 573–579, 1992PubMedCrossRefGoogle Scholar
  17. 17.
    White CJ, Maxwell CJ, Gallin JI: Changes in the structural and functional properties of human eosinophils during experimental hookworm infection. J Infect Dis 159: 778–783, 1986CrossRefGoogle Scholar
  18. 18.
    Gilles HM: Selective primary health care: strategies for control of disease in the developing world. XVII. Hookworm infection and anemia. Rev Infect Dis 7: 111–118, 1985PubMedCrossRefGoogle Scholar
  19. 19.
    Yoshida Y, Nakanishi Y, Mitani W: Experimental studies on the infection mode of Ancylostoma duodenale and Necator americanus to the definitive host. Jpn J Parasitol 7: 102–112, 1958Google Scholar
  20. 20.
    Crosby WH: What became of chlorosis? JAMA 257: 2799–2800, 1987PubMedCrossRefGoogle Scholar
  21. 21.
    Hotez PJ: Hookworm disease in children. Pediatr Infect Dis J 8: 516–520, 1989PubMedCrossRefGoogle Scholar
  22. 22.
    Stephenson LS, Latham MC, Kurz SN, et al: Treatment with a single dose of albendazole improves growth of Kenyan schoolchildren with hookworm, Trichuris trichiura, and Ascaris lumbricoides infections. Am J Trop Med Hyg 41: 78–87, 1989PubMedGoogle Scholar
  23. 23.
    Kobayashi A, Suzuki N, Yasuda I, et al: The resistance of hookworm eggs to lower temperatures. Jpn J Parasitol 8: 637, 1959Google Scholar

Copyright information

© Springer-Verlag New York, Inc. 1995

Authors and Affiliations

  • Dickson D. Despommier
    • 1
  • Robert W. Gwadz
    • 2
  • Peter J. Hotez
    • 3
  1. 1.College of Physicians and SurgeonsColumbia University, Presbyterian HospitalNew YorkUSA
  2. 2.Laboratory of Malaria Research, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  3. 3.Yale University School of MedicineNew HavenUSA

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