Growth Hormone Releasing Hormone Receptor in Human Breast Cancer Cell Line MCF-7
Growth hormone secretion from the pituitary is regulated by somatostatin (SS) and growth hormone releasing hormone (GHRH) (1,2). Interestingly, SS actions via specific receptor subtypes are widely described in peripheral normal and tumoral tissues (3, 4). In contrast, the synthesis of GHRH and its actions in peripheral tissues are poorly reported (5–7). In addition, the recently cloned GHRH receptors having seven membrane-spanning domains were only expressed in the pituitary, thus reinforcing an exclusive pituitary activity (8, 9). However, the handling of GHRH is technically challenging due to the very “sticky” GHRH and could lead to doubtful data, particularly when the receptor level is low.
KeywordsAdenoma Adenosine Prostaglandin PGE2 Neuroblastoma
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