Abstract
Growth hormone releasing peptides (GHRPs) are chemically synthesized and designed entities with no sequence relationship to any known peptide hormone (1–4). Unusual in the realm of drug design, they are peptides that have been invented prior to the discovery of the endogenous peptide hormone. In fact after more than 13 years of study, the putative GHRP-like hormone and its receptor have yet to be isolated. Further, GHRPs act in fundamentally different ways than GHRH, as described by Bowers et al. (5), and synergistically release GH when administered together with GHRH. The endocrinology and structure/activity relationships of GHRPs pose challenging problems to scientists, and answers are being actively pursued.
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References
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© 1996 Springer-Verlag New York, Inc.
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Momany, F.A., Bowers, C.Y. (1996). Computer-Assisted Modeling of Xenobiotic Growth Hormone Secretagogues. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone Secretagogues. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2396-2_5
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DOI: https://doi.org/10.1007/978-1-4612-2396-2_5
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