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T-Cell Development and Tolerance in Virus-Specific Transgenic Models

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Genetic Models of Immune and Inflammatory Diseases

Part of the book series: Serono Symposia USA ((SERONOSYMP))

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Abstract

The T-cell receptor (TCR) is expressed on the surface of T lymphocytes and is responsible for the specific recognition of foreign peptide antigens presented in the context of self major histocompatibility complex (MHC) molecules. This heterodimeric receptor consists of an α and β chain that is randomly generated by somatic rearrangement of germline variable, diversity, and joining region gene segments (1, 2).

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Authors
  1. Pamela S. Ohashi
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Editors and Affiliations

  1. Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, 02115, Boston, MA, USA

    Abul K. Abbas M.D.

  2. Section of Immunobiology, Yale University School of Medicine, 06520, New Haven, CT, USA

    Richard A. Flavell Ph.D.

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© 1996 Springer-Verlag New York, Inc.

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Ohashi, P.S. (1996). T-Cell Development and Tolerance in Virus-Specific Transgenic Models. In: Abbas, A.K., Flavell, R.A. (eds) Genetic Models of Immune and Inflammatory Diseases. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2376-4_4

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  • DOI: https://doi.org/10.1007/978-1-4612-2376-4_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7520-6

  • Online ISBN: 978-1-4612-2376-4

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