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Nucleocytoplasmic Shuttling of Estrogen Receptors is Blocked by “Pure Anti-Estrogens”

  • Sophie Dauvois
  • Malcolm G. Parker
Conference paper

Abstract

The estrogen receptor belongs to a large family of nuclear receptors whose activity as a transcription factor depends on the binding of a hormonal ligand (1). As with other steroid receptors, in the absence of ligand the estrogen receptor is found in an oligomeric complex that is unable to bind to DNA (2–4). Following hormone binding, the complex is dissociated to allow receptor dimerization, high-affinity DNA binding, and transcriptional activation (5, 6). In the estrogen receptor, there are at least two regions called activation functions, or AFs, which are required to stimulate transcription (7, 8). The relative activities of AF-1, located in the N-terminal domain, and AF-2, in the C-terminal hormone binding domain, vary according to the responsive promoter and target cells.

Keywords

Estrogen Receptor Human Estrogen Receptor Nucleocytoplasmic Shuttle Estrogen Receptor Content Nuclear Target Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc. 1996

Authors and Affiliations

  • Sophie Dauvois
  • Malcolm G. Parker

There are no affiliations available

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