Regulation of Prostate Growth and Gene Expression: Role of Stroma
Cellular interaction is recognized as a continuing event, essential in multicellular organisms for acquiring preprogrammed structure and assuming differentiated functions. Aberrant cellular interaction could create misguided signals between cells, resulting in developmental defects and unregulated growth control in both vertebrate and invertebrate organisms. Examples found in the mammalian species are the mosaic Tfm/y mice, which produced offspring that might inherit regional developmental defects of their reproductive organs (1). Reactivation of the inductive potential of embryonic mesenchymes in the adult prostate gland was proposed as one underlying mechanism for the histogenesis of benign prostatic hyperplasia (2).
KeywordsLNCaP Cell Human Prostate Cancer Prostate Growth Genomic Adaptation Soluble Growth Factor
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