Regulation of Prostate Growth and Gene Expression: Role of Stroma

  • Leland W. K. Chung
  • Chuan Gao
  • Haiyen E. Zhau
Conference paper


Cellular interaction is recognized as a continuing event, essential in multicellular organisms for acquiring preprogrammed structure and assuming differentiated functions. Aberrant cellular interaction could create misguided signals between cells, resulting in developmental defects and unregulated growth control in both vertebrate and invertebrate organisms. Examples found in the mammalian species are the mosaic Tfm/y mice, which produced offspring that might inherit regional developmental defects of their reproductive organs (1). Reactivation of the inductive potential of embryonic mesenchymes in the adult prostate gland was proposed as one underlying mechanism for the histogenesis of benign prostatic hyperplasia (2).


LNCaP Cell Human Prostate Cancer Prostate Growth Genomic Adaptation Soluble Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Schleicher G, Stumpf WE, Thiedemann K, Drews U (1988) Intersex mice composed of androgen insensitive Tfm and wild-type cells analyzed by 3H dihydrotestosterone autoradiography. Anat Embryol 178:521–528.PubMedCrossRefGoogle Scholar
  2. 2.
    McNeal, JE (1978) Origin and evolution of benign prostate enlargement. Invest Urol 15:340–345.PubMedGoogle Scholar
  3. 3.
    Chung LWK, Chang SM, Bell C, et al., (1989) Co-inoculation of tumorigenic rat prostate mesenchymal cells with non-tumorigenic epithelial cells results in the development of carcinosarcoma in syngeneic and athymic animals. Int J Cancer 43:1179–1187.PubMedCrossRefGoogle Scholar
  4. 4.
    Cunha GR, Chung LWK (1981) Stromal-epithelial interaction: I. Induction of prostatic phenotype in urothelium of testicular feminized (TFm/y) mice. J Steroid Biochem 14:1317–1321.PubMedCrossRefGoogle Scholar
  5. 5.
    Chung LWK and Cunha GR (1983) Stromal-epithelial interactions: II. Regulation of prostate growth by embryonic urogenital sinus mesenchyme. Prostate 4:503–511.PubMedCrossRefGoogle Scholar
  6. 6.
    Lasnitzki I, Mizuno T (1980) Prostatic induction: Interaction of epithelium and mesenchyme from normal wild type mice and androgen-insensitive mice with testicular feminization. J Endocrinol 85:423–428.PubMedCrossRefGoogle Scholar
  7. 7.
    Neubauer BL, Best K, Hoover DM, et al., (1986) Mesenchymal-epithelial interactions as factors influencing male accessory sex organ growth in the rat. Federation Proc 45:2618–2626.Google Scholar
  8. 8.
    Chung LWK, Gleave ME, Hsieh J, et al., (1991) Reciprocal mesenchymalepithelial interaction affecting prostate tumour growth and hormonal responsiveness. Cancer Surveys 11:91–121.PubMedGoogle Scholar
  9. 9.
    Chung LWK, Chang SM, Bell C, et al., (1988) Prostatic carcinogenesis evoked by cellular interaction. Environ Health Perspect 77:23–28.PubMedCrossRefGoogle Scholar
  10. 10.
    Zhau HYE, Hong SJ, Chung LWK (1994) A fetal rat urogenital sinus mesenchymal cell line (rUGM) accelerated growth and conferral of androgen-induced growth responsiveness to a human bladder cancer epithelial cell line in vivo. Int J Cancer 56:706–714.PubMedCrossRefGoogle Scholar
  11. 11.
    Chung LWK, Hong SJ, Zhau HYE, et al., (1991) Fibroblast-mediated human epithelial tumor growth and hormonal responsiveness in vivo. Mol Cell Biol Prostate Cancer 19:91–102.Google Scholar
  12. 12.
    Gleave ME, Hsieh JT, Gao C, et al., (1991) Acceleration of human prostate cancer growth in vivo by prostate and bone fibroblasts. Cancer Res 51:3753–3761.PubMedGoogle Scholar
  13. 13.
    Chung LWK, Li W, Gleave ME, et al., (1992) Human prostate cancer model: Roles of growth factors and extracellular matrices. J Cell Biochem 16H:99–105.CrossRefGoogle Scholar
  14. 14.
    Gao C (1994) Molecular mechanisms of prostate cancer growth and differentiation: Roles of BPGF-1 and extracellular matrices. Ph.D. thesis submitted to Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Texas.Google Scholar
  15. 15.
    Horoszewicz JS, Leong SS, Chu TM, et al., (1980) The LNCaP cell line--A new model for studies on human prostatic carcinoma. In Murphy GP (ed): Models for Prostate Cancer. New York: Alan R Liss, Inc, pp 115–132.Google Scholar
  16. 16.
    Stephenson RA, Dinney CPN, Gohji K, et al., (1992) Metastatic model for human prostate cancer using orthotopic implantation in nude mice. J Natl Cancer Inst 84:951–957.PubMedCrossRefGoogle Scholar
  17. 17.
    Pretlow TG, Delmoro CM, Dilley GG, et al., (1991) Transplantation of human prostatic carcinoma into nude mice in Matrigel. Cancer Res 51:3814–3817.PubMedGoogle Scholar
  18. 18.
    Gleave ME, Hsieh JT, von Eschenbach AC, Chung LWK (1992) Prostate and bone fibroblasts induce human prostate cancer growth in vivo: Implications for bidirectional stromal-epithelial interaction in prostate carcinoma growth and metastasis. J Urol 147:1151–1159.PubMedGoogle Scholar
  19. 19.
    Fu X, Herrera H, Hoffman RM (1992) Orthotopic growth and metastasis of human prostate carcinoma in nude mice after transplantation of histologically intact tissue. Int J Cancer 52:987–990.CrossRefGoogle Scholar
  20. 20.
    Thalmann GN, Anezinis PE, Chang SM, et al., (1994) Androgen independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer. Cancer Res 54:2577–2581.PubMedGoogle Scholar
  21. 21.
    Chung LWK (1994) The role of stromal-epithelial interactions in normal and malignant growth. Cancer Sur 23:33–42.Google Scholar
  22. 22.
    Wu, HS, Hsieh JT, Gleave ME, et al., (1994) Derivation of androgen independent human LNCaP prostatic cancer cell sublines: Role of bone stromal cells. Int J Cancer 57:406–412.CrossRefGoogle Scholar
  23. 23.
    Foster, PL (1993) Adaptive mutation. Ann Rev Microbiol 47:467–504.CrossRefGoogle Scholar
  24. 24.
    Foulds, L (1969) Neoplastic Development, Vol 1. New York: Academic Press, pp 72–74.Google Scholar
  25. 25.
    Rubin H (1994) Experimental control of neoplastic progression in cell populations: Foulds’ rules revisited. Proc Natl Acad Sci, USA 91:6619–6623.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1996

Authors and Affiliations

  • Leland W. K. Chung
  • Chuan Gao
  • Haiyen E. Zhau

There are no affiliations available

Personalised recommendations