Growth Factors in Endometrial Cancer

  • Naoki Terakawa
Conference paper


Progressive tumor growth has been associated with neovascularization induced by an angiogenic factor(s) that the tumor secretes (1). Therefore, inhibition of neovascularization could be effective in suppressing tumor growth (2). The antiproliferative effects of progestins in human endometrial cancer cells have been demonstrated by several investigators. Previously, we reported that the growth of human endometrial adenocarcinoma cells in primary culture was significantly suppressed by medroxyprogesterone acetate (MPA) (3); a similar growth-inhibitory effect has been reported in a nude mouse system (4). We have suggested that the antiproliferative effect of progestin on adenocarcinoma cells is mediated through progestin receptors (PR) present in the cells (5). In contrast, using the rabbit cornea assay, Gross et al. have shown that MPA inhibits the angiogenesis induced by several tumors of laboratory animals (6). Recent studies have shown that human endometrial adenocarcinoma cells produce angiogenic factors (7). Although MPA seems to act directly on endometrial cancer cells to inhibit their growth, the present data suggest that its inhibition of angiogenesis may share the same mechanism by which it inhibits the growth of endometrial adenocarcinoma. In the present study, to gain further information on MPA’s mechanism of action in human endometrial cancer, we examined MPA’s effect on angiogenesis induced by adenocarcinoma. We also investigated the synthesis and secretion of angiogenic growth factor(s) in a human endometrial cancer cell line.


Endometrial Cancer Angiogenic Factor Medroxyprogesterone Acetate Endometrial Cancer Cell Endometrial Adenocarcinoma 
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© Springer-Verlag New York, Inc. 1996

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  • Naoki Terakawa

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