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Gene Expression in Familial Breast Cancer: A Genetic-Epidemiologic Study of Premenopausal Bilateral Breast Cancer

  • Robert W. Haile
  • Sue Ingles
  • Victoria K. Cortessis
  • Robert C. Millikan
  • Anh Diep
  • Robert S. Sparkes
Conference paper

Abstract

The objectives of our study are to identify and characterize genes involved in the etiology of breast cancer, to define sources of heterogeneity, and to identify factors that may affect expression of inherited susceptibility genes (i.e., gene-gene and gene-environment interactions).

Keywords

Breast Cancer Ovarian Cancer Oral Contraceptive Familial Breast Cancer Reproductive Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Cortessis V, Ingles S, Millikan R, et al. (1993) Linkage Analysis of DRD2, a marker linked to the ataxia-telangiectasia gene, in 64 families with premenopausal bilateral breast cancer. Cancer Res 53:5083–5086.PubMedGoogle Scholar
  2. 2.
    Cortessis V, Ingles S, Millikan R et al (1995) A linkage analysis of MFD188 in 66 families with premenopausal bilateral breast cancer, with a focus on heterogeneity. Submitted.Google Scholar
  3. 3.
    Millikan RC, Ingles S, Diep A, et al., (1995) Linkage analysis of chromosome IP using 66 multiple case breast cancer pedigrees. Submitted.Google Scholar
  4. 4.
    Ingles S, Millikan RC, Slamon D, et al., (1995) Descriptive epidemiology of HER-2 and p53 overexpression in bilateral breast cancer prevalence, concordance, and associations with BRCA1 and reproductive factors. Submitted.Google Scholar
  5. 5.
    Slamon DJ, Godolphin W, Jones LA et al (1989) Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244:707–712.PubMedCrossRefGoogle Scholar
  6. 6.
    Lange K, Boehnke M, Weeks D (1988) Programs for Pedigree Analysis: MENDEL, FISHER, and dGENE. Genetic Epidem 5:471–472.CrossRefGoogle Scholar
  7. 7.
    Claus E, Risch N, Thompson WD (1991) Genetic analysis of br east cancer in the Cancer and Steroid Hormone Study. Am J Hum Genet 48:232–242.PubMedGoogle Scholar
  8. 8.
    Page D, Anderson T (1987) Diagnostic histopathology of the breast. New York: Churchill Livingston.Google Scholar
  9. 9.
    Ott J (1983) Linkage analysis and family classification under heterogeneity. Ann Hum Genet 47:311–320.PubMedCrossRefGoogle Scholar
  10. 10.
    Ingles S, Diep A, Haile RW (1995) A logistic random-effects model for gene-environment interaction under linkage heterogeneity: Application to early-onset bilateral breast cancer data. Submitted.Google Scholar

Copyright information

© Springer-Verlag New York, Inc. 1996

Authors and Affiliations

  • Robert W. Haile
  • Sue Ingles
  • Victoria K. Cortessis
  • Robert C. Millikan
  • Anh Diep
  • Robert S. Sparkes

There are no affiliations available

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