Breast Cancer Incidence in Women Exposed to Estrogen and Estrogen-Progestin Replacement Therapy

  • Ingemar Persson
Conference paper


Hormone replacement therapy (HRT) is widely used, mainly to relief vasomotor symptoms, but also for long-term protection against osteoporosis and cardiovascular disease. However, the alleged relationship between HRT and increased risk of postmenopausal breast cancer is of major concern. Since breast cancer is a frequent and serious disease, an association between HRT and an enhanced risk of breast cancer could cause a substantial number of new cases of or deaths from breast cancer. The aim of this presentation is to summarize briefly the available literature.


Breast Cancer Relative Risk Breast Cancer Risk Hormone Replacement Therapy Estrogen Replacement Therapy 
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  1. 1.
    Adami HO, Adams G, Boyle P, et al. (1990) Breast cancer etiology. Report from a working party for the Nordic Cancer Union Meeting, 1989. Int J Cancer 5:22–39.Google Scholar
  2. 2.
    Kelsey JL, Hildreth NG (1983) Breast and gynecologic cancer epidemiology CRC Press, Boca Raton, FL.Google Scholar
  3. 3.
    Negri E, La Vecchia C, Bruzzi. (1988) Risk factors for breast cancer: Pooled results from three Italian case-control studies. Am J Epidemiol 128:1207–1215.PubMedGoogle Scholar
  4. 4.
    Boyle P (1988) Epidemiology of breast cancer. Bailliere’s Clinical Oncology 2:1–59.Google Scholar
  5. 5.
    Brinton LA, Schairer C, Hoover RN, Fraumeni JF (1988) Menstrual factors and risk of breast cancer. Cancer Invest 6:245–254.PubMedCrossRefGoogle Scholar
  6. 6.
    Henderson BE, Ross RK, Judd HL, et al. (1985) Do regular ovulatory cycles increase breast-cancer risk? Cancer 56:1206–1208.PubMedCrossRefGoogle Scholar
  7. 7.
    Rose DP (1986) Dietary factors and breast cancer. Cancer Surv 5:671–688.PubMedGoogle Scholar
  8. 8.
    Key TJA, Pike MC (1988) The role of oestrogens and progestogens in the epidemiology and prevention of breast cancer. Eur J Cancer Clin Oncol 24:29–43.PubMedCrossRefGoogle Scholar
  9. 9.
    Ferguson DJP, Anderson TJ (1981) Morphological evaluation of cell turnover in relation to the menstrual cycle in the ‘resting’ human breast. Brit J Cancer 44:177–181.PubMedCrossRefGoogle Scholar
  10. 10.
    Mauvais-Jarvis P, Kuttenn F, Gompel A (1986) Antiestrogen action of progesterone in breast tissue. Breast Cancer Res Treat 8:179–87.PubMedCrossRefGoogle Scholar
  11. 11.
    Clarke CL, Sutherland RL (1990) Progestin regulation of cellular proliferation. Endocrine Rev 11:260–300.CrossRefGoogle Scholar
  12. 12.
    Steinberg KK, Thacker SB, Smith SJ, et al. (1991) A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer. JAMA 265:1985–1990.PubMedCrossRefGoogle Scholar
  13. 13.
    Dupont WD, Page DL (1991) Menopausal estrogen replacement therapy and breast cancer. Arch Intern Med 151:67–72.PubMedCrossRefGoogle Scholar
  14. 14.
    Palmer JR, Rosenberg L, Clarke EA, et al. (1991) Breast cancer risk after estrogen replacement therapy: Results from the Toronto Breast Cancer Study. Am J Epidemiol 134:1386–1395.PubMedGoogle Scholar
  15. 15.
    Kaufman DW, Palmer JR, de Mouzon J, et al. (1991) Estrogen replacement therapy and the risk of breast cancer: Results from the Case-Control Surveillance Study. Am J Epidemiol 134:1375–1385.PubMedGoogle Scholar
  16. 16.
    Harris RE, Namboodiri KK, Wynder EL (1992) Breast cancer risk: Effects of estrogen replacement therapy and body mass. J Natl Cancer Inst 84:1575–1582.PubMedCrossRefGoogle Scholar
  17. 17.
    Yang CP, Daling JR, Band PR, et al. (1992) Noncontraceptive hormone use and risk of breast cancer. Cancer Causes Cont 3:475–479.CrossRefGoogle Scholar
  18. 18.
    Colditz GA, Stampfer MJ, Willett WC, et al. (1992) Type of postmenopausal hormone use and risk of breast cancer: 12-year follow-up from the Nurses’ Study. Cancer Causes Cont 3:433–439.CrossRefGoogle Scholar
  19. 19.
    Brinton LA, Hoover R, Fraumeni JF Jr (1986) Menopausal oestrogens and breast cancer risk: An expanded case-control study. Br J Cancer 54:825–832.PubMedCrossRefGoogle Scholar
  20. 20.
    McDonald JA, Weiss NS, Daling JR, et al. (1986) Menopausal estrogen use and the risk of breast cancer. Breast Cancer Res Treat 7:193–199.PubMedCrossRefGoogle Scholar
  21. 21.
    La Vecchia C, Decarli A, Parazzini F, et al. (1986) Non-contraceptive oestrogens and the risk of breast cancer in women. Int J Cancer 38:853–858.PubMedCrossRefGoogle Scholar
  22. 22.
    Wingo PA, Layde PM, Lee NC, et al. (1987) The risk of breast cancer in postmenopausal women who have used estrogen replacement therapy. JAMA 257:209–215.PubMedCrossRefGoogle Scholar
  23. 23.
    Ewertz M (1988) Influence of non-contraceptive exogenous and endogenous sex hormones on breast cancer risk in Denmark. Int J Cancer 42:832–838.PubMedCrossRefGoogle Scholar
  24. 24.
    Buring JE, Hennekens CH, Lipnick RJ, et al. (1987) A prospective cohort study of postmenopausal hormone use and risk of breast cancer in US women. Am J Epidemiol 125:939–947.PubMedGoogle Scholar
  25. 25.
    Hunt K, Vessey M, McPherson K, Coleman M (1987) Long-term surveillance of mortality and cancer incidence in women receiving hormone replacement therapy. Brit J Obstet Gynecol 94:620–635.CrossRefGoogle Scholar
  26. 26.
    Mills PK, Beeson WL, Phillips RL, Fraser GE (1989) Prospective study of exogenous hormone use and breast cancer in Seventh-Day Adventists. Cancer 64:591–597.PubMedCrossRefGoogle Scholar
  27. 27.
    Bergkvist L, Adami HO, Persson I, et al. (1989) The risk of breast cancer after estrogen and estrogen-progestin replacement. N Engl J Med 321:293–297.PubMedCrossRefGoogle Scholar
  28. 28.
    Colditz GA, Stampfer MJ, Willett, et al. (1990) Prospective study of estrogen replacement therapy and risk of breast cancer in menopausal women. JAMA 264:2648–2655.PubMedCrossRefGoogle Scholar
  29. 29.
    UK National Case Control Study Group (1989) Oral contraceptive use and breast cancer risk in young women. Lancet 1:973–982.Google Scholar
  30. 30.
    Paul C, Skegg DCG, Spears GFS (1989) Depot medroxyprogesterone (Depo-Provera) and risk of breast cancer. Brit Med J 299:759–762.PubMedCrossRefGoogle Scholar
  31. 31.
    Collins J, Donner A, Allen LH, Adams O (1980) Oestrogen use and survival in endometrial cancer. Lancet 11:961–964.CrossRefGoogle Scholar
  32. 32.
    Bergkvist L, Adami HO, Persson I, et al. (1989) Prognosis after breast cancer diagnosed in women exposed to estrogen and estrogen-progestogen replacement therapy. Am J Epidemiol 130:221–228.PubMedGoogle Scholar

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© Springer-Verlag New York, Inc. 1996

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  • Ingemar Persson

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