31P-MRS of Muscle Pathophysiology
Muscle fatigue and weakness are common clinical complaints, the underlying causes of which are often difficult to determine. The advent of 31P-MRS has provided a powerful tool to identify and study muscle disease.1 Indeed, some of the first in vivo studies employing 31P-MRS were studies of muscle pathologies.2,3 This chapter will review some of the muscle pathologies that have been studied using 31P-MRS.
KeywordsChronic Fatigue Syndrome Duchenne Muscular Dystrophy Muscle Energy Metabolism Phosphorus Magnetic Resonance Spectroscopy Creatine Kinase Equilibrium
Unable to display preview. Download preview PDF.
- 3.Gadian DG, Radda RK, Ross BD, et al. 31P NMR examination of a myopathy. Lancet 1981;2:744–775.Google Scholar
- 6.Blei ML, Conley KE, Kushmerick MJ. Separate measures of ATP ultilization and recovery in human skeletal muscle. J Physiol (Lond) 1993;456:203–222.Google Scholar
- 7.Kemp GJ, Radda GK. Quantitative interpretation of bio-energetic data from 31P and 1H magnetic resonance spectroscopic studies of skeletal muscle: an analytical review. Mag Res Quart 1994;10:43–63.Google Scholar
- Bank W, Argov Z, Leigh JS, Chance B. The value of 31P NMR in the diagnosis and monitoring the course of human myopathies. Ann NY Acad Sci 1986:448–450.Google Scholar
- 15.Argov Z, Bank WJ, Maris J, et al. Muscle energy metabolism in human phosphofructokinase deficiency as recorded by 31P nuclear magnetic resonance spectroscopy. Ann Neurol 1987;16:529–538.Google Scholar
- 17.McCully KK, Kent JA, Chance B. Muscle injury and exercise stress measured with 31-P magnetic resonance spectroscopy. In: Paul R, Elzinga G, Yamada K, eds. Muscle energetics. Progress in clinical and biological research, vol. 315.1989:197–207. New York, Alan RLiss, Inc.Google Scholar
- 18.McArdle B. Myopathies due to a defect in muscle glycogen breakdown. Clin Sci 1951;10:13–35.Google Scholar
- 22.Argov Z, Bank WJ, Maris J, et al. Treatment of mitochondrial myopathy due to complex III deficiency with vitamins K3 and C: a 31P-NMR follow-up study. 1986;19:598–602.Google Scholar
- 29.Zatina M, Berkowitz H, Gross G, et al. 31-P nuclear magnetic resonance spectroscopy: noninvasive biochemical analysis of the ischemic extremity. J Vase Surg 1986;3: 411–420.Google Scholar