Perimenopause pp 101-118 | Cite as

Dissociation of Endocrine and Gametogenic Ovarian Function

  • Gregory F. Erickson
Part of the Serono Symposia USA book series (SERONOSYMP)

Abstract

Aging in women is associated with decreased fecundity as a result of the failure of dominant follicles to release eggs that can undergo normal embryonic development (1–4). In vitro fertilization (IVF) studies (5, 6) have demonstrated that this decrease becomes particularly evident in patients after 36 years of age when pregnancy rates (PR) with self-oocytes decrease sharply by ~65%, i.e., from a ~25% per transfer in women ≤ 30 years of age to ~9% per transfer in women after the age of 36 (6). A similar age-related decrease in female fecundity has been found using artificial insemination donor (AID) (7) and gamete intrafallopian transfer (GIFT) (8). The low fecundity rate continues through ~44 years, after which viable pregnancies almost never occur (8–10).

Keywords

Estrogen Morphine Shrinkage Germinal Serine 

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© Springer-Verlag New York, Inc. 1997

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  • Gregory F. Erickson

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