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Perimenopause pp 184–201Cite as

Vasomotor Symptoms in the Perimenopause

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Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

Hot flashes, the sine qua non of menopause, are experienced by a majority of menopausal women in Western countries, and by a substantial number in many other countries and cultures (1–3). However, hot flashes are perhaps even more disturbing, if not more prevalent, in women during the transition period into the menopause—the perimenopausal period—than at or after menopause. Whether in pre-, peri-, or postmenopausal women, the physiologic phenomenon of a hot flash itself seems to be no different.

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References

  1. Kronenberg F. Hot flashes: epidemiology and physiology. Ann NY Acad Sci 1990;592:52–86.

    Article  PubMed  CAS  Google Scholar 

  2. Boulet MJ, Oddens BJ, Lehert P, Vemer HM, Visser A. Climacteric and menopause in seven south-east Asian countries. Maturitas 1994;19:157–76.

    Article  PubMed  CAS  Google Scholar 

  3. Oldenhave A, Jaszmann LJB, Haspels AA, Everaerd WTAM. Impact of climacteric on well-being; a survey based on 5213 women 39 to 60 years old. Am J Obstet Gynecol 1993;169:772–80.

    Google Scholar 

  4. Matthews KA, Wing RR, Kuller LH, Meilahn EN, Plantinga P. Influence of the perimenopause on cardiovascular risk factors and symptoms of middle-aged healthy women. Arch Intern Med 1994;154:2349–55.

    Article  PubMed  CAS  Google Scholar 

  5. Pansini F, Albertazzi P, Bonnaccorsi G, et al. The menopausal transition: a dynamic approach to the pathogenesis of neurovegetative complaints. Eur J Obstet Gynecol Reprod Biol 1994;57:103–9.

    Article  PubMed  CAS  Google Scholar 

  6. Jaszmann L, Van Lith ND, Zaat JAC. The perimenopausal symptoms: the statistical analysis of a survey. Part A and B. Med Gynaecol Androl Sociol 1969;4:268–77.

    Google Scholar 

  7. Hagstad A, Janson PO. The epidemiology of climacteric symptoms. Acta Obstet Gynecol Scand Suppl 1986;134:59–65.

    Article  PubMed  CAS  Google Scholar 

  8. DeFazio J, Meldrum DR, Laufer L, et al. Induction of hot flashes in premenopausal women treated with a long-acting GnRH agonist. J Clin Endocrinol Metab 1983;56:445–8.

    Article  PubMed  CAS  Google Scholar 

  9. Kronenberg F, Cote LJ, Linkie DM, Dyrenfurth I, Downey JA. Menopausal hot flashes: thermoregulatory, cardiovascular, and circulating catecholamine and LH changes. Maturitas 1984;6:31–43.

    Article  PubMed  CAS  Google Scholar 

  10. Voda AM. Climacteric hot flash. Maturitas 1981;3:73–90.

    Article  PubMed  CAS  Google Scholar 

  11. Gannon L, Hansel S, Goodwin J. Correlates of menopausal hot flashes. J Behav Med 1987;10:277–85.

    Article  PubMed  CAS  Google Scholar 

  12. Erlik Y, Meldrum DR, Judd HL. Estrogen levels in postmenopausal women with hot flashes. Obstet Gynecol 1982;59:403–7.

    PubMed  CAS  Google Scholar 

  13. McKinlay SM, Brambilla DJ, Posner JG. The normal menopause transition. Am J Hum Biol 1992;4:37–46.

    Article  Google Scholar 

  14. Lock M, Kaufert P, Gilbert P. Cultural construction of the menopausal syndrome: the Japanese case. Maturitas 1988;10:317–32.

    Article  PubMed  CAS  Google Scholar 

  15. Adlercreutz H, Hamalainen E, Gorbach S, Goldin B. Dietary phyto-oestrogens and the menopause in Japan. Lancet 1992;339:1233.

    Article  PubMed  CAS  Google Scholar 

  16. Setchell KDR, Bordello SP, Hulme P, Kirk DN, Axelson M. Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease. Am J Clin Nutr 1984;40:569–78.

    PubMed  CAS  Google Scholar 

  17. Wilcox G, Wahlqvist ML, Burger HG, Medley G. Oestrogenic effects of plant foods in postmenopausal women. Br Med J 1990;301:905–6.

    Article  CAS  Google Scholar 

  18. Tataryn IV, Lomax P, Bajorek JG, Chesarek W, Meldrum DR, Judd HL. Postmenopausal hot flushes: a disorder of thermoregulation. Maturitas 1980; 2:101–7.

    Article  PubMed  CAS  Google Scholar 

  19. Ginsburg J, Swinhoe J, O’Reilly B. Cardiovascular responses during the menopausal hot flush. Br J Obstet Gynaecol 1981;88:925–30.

    Article  PubMed  CAS  Google Scholar 

  20. Freedman RR, Norton D, Woodward S, Cornelissen G. Core body temperature and circadian rhythm of hot flashes in menopausal women. J Clin Endocrinol Metab 1995;80(8):2354–8.

    Article  PubMed  CAS  Google Scholar 

  21. Woodward S, Greville HW, Freedman RR. Ventilatory response during menopausal hot flashes. Menopause 1995;2(2):81–8.

    Article  Google Scholar 

  22. Khan SA, Pace JE, Cox ML, Gau DW, Cox SAL, Hodkinson HM. Climacteric symptoms in healthy middle-aged women. Br J Clin Pract 1994;48(5):240–2.

    PubMed  CAS  Google Scholar 

  23. Casper RF, Yen SSC, Wilkes MM. Menopausal flushes: a neuroendocrine link with pulsatile luteinizing hormone secretion. Science 1979;205:823–5.

    Article  PubMed  CAS  Google Scholar 

  24. Tataryn IV, Meldrum DR, Lu KH, Frumar AM, Judd HL. LH, FSH and skin temperature during menopausal hot flush. J Clin Endocrinol Metab 1979;49:152–4.

    Article  PubMed  CAS  Google Scholar 

  25. Mulley G, Mitchell JRA, Tattersall RB. Hot flushes after hypophysectomy. Br Med J 1977;2:1062.

    Article  PubMed  CAS  Google Scholar 

  26. Meldrum DR, Erlik Y, Lu JKH, Judd HL. Objectively recorded hot flushes in patients with pituitary insufficiency. J Clin Endocrinol Metab 1981;52:684–7.

    Article  PubMed  CAS  Google Scholar 

  27. Casper RF, Yen SSC. Menopausal flushes: effect of pituitary gonadotropin desensitization by a potent luteinizing hormone releasing factor agonist. J Clin Endocrinol Metab 1981;53:1056–8.

    Article  PubMed  CAS  Google Scholar 

  28. Genazzani AR, Petraglia F, Facchinetti F, Facchini V, Volpe A, Alessandrini G. Increase of proopiomelanocortin-related peptides during subjective menopausal flushes. Am J Obstet Gynecol 1984;149:775–9.

    PubMed  CAS  Google Scholar 

  29. Meldrum DR, Tataryn IV, Frumar AM, Erlik Y, Lu KH, Judd HL. Gonadotropins, estrogens, and adrenal steroids during the menopausal hot flash. J Clin Endocrinol Metab 1980;50:685–9.

    Article  PubMed  CAS  Google Scholar 

  30. Meldrum DR, DeFazio JD, Erlik Y, et al. Pituitary hormones during the menopausal hot flash. Obstet Gynecol 1984;64:752–6.

    PubMed  CAS  Google Scholar 

  31. Freedman RR, Woodward S, Mayes MM. Nonneural mediation of digital vasodilation during menopausal hot flushes. Gynecol Obstet Invest 1994; 38:206–9.

    Article  PubMed  CAS  Google Scholar 

  32. Kronenberg F. Menopausal hot flashes: randomness or rhythmicity. Chaos 1991;l(3):271–8.

    Article  Google Scholar 

  33. Coope J, Williams S, Patterson JS. A study of the effectiveness of propranolol in menopausal hot flushes. Br J Obstet Gynaecol 1978;85:472–5.

    Article  PubMed  CAS  Google Scholar 

  34. Moinar G. Menopausal hot flashes: their cycles and relation to air temperature. Obstet Gynecol 1981;57:52S-55S.

    Google Scholar 

  35. Voda AM. Menopausal hot flash. In: Voda A, Dinnerstein M, O’Donnell SR, eds. Changing perspectives in menopause. Austin: University of Texas Press, 1982; 136–59.

    Google Scholar 

  36. Kronenberg F, Barnard RM. Modulation of menopausal hot flashes by ambient temperature. J Therm Biol 1992;17:43–9.

    Article  Google Scholar 

  37. Haas S, Walsh B, Evans S, Krache M, Ravnikar V, Schiff I. The effect of transdermal estradiol on hormone and metabolic dynamics over a six-week period. Obstet Gynecol 1988;71:671–6.

    PubMed  CAS  Google Scholar 

  38. Christy CJ. Vitamin E in menopause. Am J Obstet Gynecol 1945;50:84–7.

    Google Scholar 

  39. Ferguson HE. The use of vitamin E in menopausal syndrome. VA Med Month 1948;75:447–8.

    CAS  Google Scholar 

  40. McLaren HC. Vitamin E in the menopause. Br Med J 1949;2:1378–82.

    Article  PubMed  CAS  Google Scholar 

  41. Blatt MHG, Wiesbader H, Kupperman HS. Vitamin E and climacteric syndrome. AMA Arch Intern Med 1953;91:792–6.

    PubMed  CAS  Google Scholar 

  42. Freedman RR, Woodward S. Behavioral treatment of menopausal hot flushes: evaluation by ambulatory monitoring. Am J Obstet Gynecol 1992;167:436–9.

    PubMed  CAS  Google Scholar 

  43. Freedman RR, Woodward S, Brown B, Javaid JI, Pandey GN. Biochemical and thermoregulatory effects of behavioral treatment for menopausal hot flashes. Menopause 1995;2:211–8.

    Article  Google Scholar 

  44. Punnonen R, Lukola A. Oestrogen-like effect of ginseng. Br Med J 1980; 281:1110.

    Article  PubMed  CAS  Google Scholar 

  45. Hopkins MP, Androff L, Benninghoff AS. Ginseng face cream and unexplained vaginal bleeding. Am J Obstet Gynecol 1988;159:1121–2.

    PubMed  CAS  Google Scholar 

  46. Van Thiel DH, Galvao-Teles A, Monteiro E, Rosenblum E, Gavaler JS. The phytoestrogens present in de-ethanolized bourbon are biologically active: a preliminary study in postmenopausal women. Alcohol Clin Exp Res 1991; 15:822–3.

    Article  PubMed  Google Scholar 

  47. Gavaler JS, Rosenblum ER, Van Thiel DH, et al. Biologically active phytoestrogens are present in bourbon. Alcohol Clin Exp Res 1987;11:399–406.

    Article  PubMed  CAS  Google Scholar 

  48. Wilbur J, Dan A, Hedricks C, Holm K. The relationship among menopausal status, menopausal symptoms, and physical activity in midlife women. Fam Community Health 1990;13:67–78.

    Google Scholar 

  49. Hammar M, Berg G, Lindgren R. Does physical exercise influence the frequency of postmenopausal hot flushes? Acta Obstet Gynecol Scand 1990;69:409–12.

    Article  PubMed  CAS  Google Scholar 

  50. Flint M, Samil RS. Cultural and subcultural meanings of the menopause. Ann NY Acad Sci 1990;592:134–48.

    Article  PubMed  CAS  Google Scholar 

  51. Axelson M, Sjovall J, Gustafsson BE, Setchell KDR. Soya—a dietary source of the non-steroidal oestrogen equal in man and animals. J Endocrinol 1984; 102:49–56.

    Article  PubMed  CAS  Google Scholar 

  52. Setchell KDR, Gosselin SJ, Welsh MB, et al. Dietary estrogensa probable cause of infertility and liver disease in captive cheetahs. Gastroenterology 1987;93:225–33.

    PubMed  CAS  Google Scholar 

  53. Stob M. Naturally occurring food toxicants: estrogens. In: Rechcigl M Jr, ed. CRC handbook of naturally occurring food toxicants. Boca Raton, FL: CRC Press, 1983:81–100.

    Google Scholar 

  54. Baird DD, Umbach DM, Landsdell L, et al. Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. J Clin Endocrinol Metab 1995;80(5): 1685–90.

    Article  PubMed  CAS  Google Scholar 

  55. Adlercreutz H, Fotsis T, Bannwart C, et al. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens, in urine of women on various habitual diets. J Steroid Biochem 1986;25:791–7.

    Article  PubMed  CAS  Google Scholar 

  56. Murkies AL, Lombard C, Strauss BJG, Wilcox G, Burger HG, Morton MS. Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat. Maturitas 1995;21:189–95.

    Article  PubMed  CAS  Google Scholar 

  57. Wyon Y, Lindgren R, Lundeberg T, Hammar M. Effects of acupuncture on climacteric vasomotor symptoms, quality of life, and urinary excretion of neuropeptides among postmenopausal women. Menopause 1995;2(1):3–12.

    Article  Google Scholar 

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Authors
  1. Fredi Kronenberg
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Editors and Affiliations

  1. Department of Obstetrics and Gynecology College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA

    Rogerio A. Lobo M.D.

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© 1997 Springer-Verlag New York, Inc.

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Kronenberg, F. (1997). Vasomotor Symptoms in the Perimenopause. In: Lobo, R.A. (eds) Perimenopause. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2288-0_14

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  • DOI: https://doi.org/10.1007/978-1-4612-2288-0_14

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7488-9

  • Online ISBN: 978-1-4612-2288-0

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