Abstract
Recall that in vertebrate embryos, the central nervous system forms along the dorsal midline of the body axis. The formation of the nervous system begins during gastrulation, when the dorsal mesoderm (chordamesoderm) moves into contact with the overlying ectoderm. The dorsal mesoderm emits signals, presumably noggin and chordin protein, which induce the overlying ectoderm to adopt a neural fate. The induced neural plate forms neural folds, the folds form the neural tube, and the neural tube forms the brain and the spinal cord. Still missing are the spinal ganglia and the essential parts of the autonomous nervous system, in particular, the sympathetic system and the peripheral components of the parasympathetic system, such as the neuronal network of the gut. These parts derive from the neural crest cells.
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© 1997 Springer-Verlag New York, Inc.
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Müller, W.A. (1997). Development of the Nervous System: Cell Migration, Pathfinding, and Self-Organization. In: Developmental Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2248-4_14
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DOI: https://doi.org/10.1007/978-1-4612-2248-4_14
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