Animal Morphogenesis Is Shaped Actively by Adhesion and Cell Migration

  • Werner A. Müller


As a result of cell division and cell differentiation, a large variety of cells with different shapes and divergent molecular constitutions and makeups appear. In turn, these cells create associations of cells serving a common function: tissues and organs. In cell associations the number, the size, and the shape of the individual cells eventually will determine the shape of the whole association. In contrast to the development of plants, in animals active shaping through intracellular contractile filaments and forces of cohesion and adhesion are observed, and extensive displacement and migration of cells take place.


Neural Cell Adhesion Molecule Neural Plate Epithelial Sheet Cell Association Extensive Displacement 
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  1. Adams, J.C., and Watt, F.M. (1993): Regulation of development and differentiation by the extracellular matrix. Development 117:1183–1198.PubMedGoogle Scholar
  2. Armstrong, P.B. (1989): Cell sorting out: The self-assembly of tissues in vitro. Crit. Rev. Biochem. Mol. Biol. 24:119–149.PubMedCrossRefGoogle Scholar
  3. Begovac, P.C., and Shur, B.D. (1990): Cell surface galactosyltransferase mediates the initiation of neurite outgrowth from PC 12 cells of laminin. J. Cell Biol. 110:461–470.PubMedCrossRefGoogle Scholar
  4. Brown, N.H. (1993) Integrins hold Drosophila together. Bioessays 15: 383–390.PubMedCrossRefGoogle Scholar
  5. Cunningham, B.A. (1991) Cell adhesion molecules and the regulation of development. Am. J. Obstet. Gynecol. 164:939–948.PubMedGoogle Scholar
  6. Drubin, D.G., and Nelson, W.J. (1996): Origins of cell polarity. Cell 84: 335–344.PubMedCrossRefGoogle Scholar
  7. Edelman, G.M. (1983): Cell adhesion molecules. Science 219:450–457.PubMedCrossRefGoogle Scholar
  8. Edelman, G.M. (1986): Cell adhesion molecules in the regulation of animal form and tissue pattern. Annu. Rev. Cell Biol. 2:81–116.PubMedCrossRefGoogle Scholar
  9. Edelman, G.M. (1988): Topobiology: An Introduction to Molecular Embryology. Basic Books, New York.Google Scholar
  10. Edelstein-Keshet, L., and Ermentrout, B.G. (1990): Contact response of cells can mediate morphogenetic pattern formation. Differentiation 45: 147–159.PubMedCrossRefGoogle Scholar
  11. Foty, R.A., et al., (1966): Surface tensions of embryonic tissues predict their mutual envelopmental behavior. Development 122:1611–1620.Google Scholar
  12. Grenningloh, G., et al. (1990). Molecular genetics of neuronal recognition in Drosophila: Evolution and function of immunoglobulin superfamily cell adhesion molecules. Cold Spring Harbor Symp. Quant. Biol. 55:327–340.PubMedGoogle Scholar
  13. Gullberg, D., and Ekblom, P. (1995): Extracellular matrix and its receptors during development. Int. J. Dev. Biol. 39:845–854.PubMedGoogle Scholar
  14. Gumbiner, B.M. (1996): Cell adhesion: The molecular basis of tissue architecture and morphogenesis. Cell 84:345–357.PubMedCrossRefGoogle Scholar
  15. Hardin, J., and Keller, R. (1988): Behavior and function of bottle cell during gastrulation of Xenopus laevis. Development 103:211–230.PubMedGoogle Scholar
  16. Holtfreter, J. (1946): Structure, motility and locomotion in isolated amphibian cells. J. Morphol. 79:27–62.PubMedCrossRefGoogle Scholar
  17. Hynes, R.O. (1992): Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 69:11–25.PubMedCrossRefGoogle Scholar
  18. Hynes, R.O., and Lander, A.D. (1992): Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell 68: 303–322.PubMedCrossRefGoogle Scholar
  19. Jacobson, A.G. (1994): Normal neurulation in amphibia. In Bock, G., and Marsh, J. (eds.) Neural Tube Defects, pp. 6–24. John Wiley & Sons, New York.Google Scholar
  20. Keller, R.E. (1986): The cellular basis of amphibian gastrulation. In Browder, L. (ed.) Developmental Biology: A Comprehensive Synthesis, Vol. 2, pp. 241–327. Plenum Press, New York.Google Scholar
  21. Phillips, D.R., Charo, I.F., and Scarborough, R.M. (1991): GPIIb-IIIA: The responsive integrin. Cell 65:359–362.PubMedCrossRefGoogle Scholar
  22. Ruoslahti, E., and Reed, J.C. (1994): Anchorage dependence, integrins and apoptosis. Cell 77:477–478.PubMedCrossRefGoogle Scholar
  23. Shur, B.D. (1991): Cell surface β1,4galactosyltransferase. Twenty years later. Glycobiology 1:563–575.PubMedCrossRefGoogle Scholar
  24. Steinberg, M.S. (1970): Does differential adhesion govern self-assembly processes in histogenesis? Equilibrium configurations and the emergence of a hierarchy among populations and animal morphogenesis. J. Exp. Zool. 173: 395–434.PubMedCrossRefGoogle Scholar
  25. Steinberg, M.S., and Takeichi, M. (1994): Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression. Proc. Natl. Acad. Sci. USA 91:206–209.PubMedCrossRefGoogle Scholar
  26. Takeichi, M. (1988): The cadherins: Cell-cell adhesion molecules controlling animal morphogenesis. Development 102:639–656.PubMedGoogle Scholar
  27. Townes, P.L., and Holtfreter, J. (1955): Directed movements and selective adhesion of embryonic amphibian cells. J. Exp. Zool. 128:53–120.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1997

Authors and Affiliations

  • Werner A. Müller
    • 1
  1. 1.Zoologisches Institut—PhysiologieUniversity of HeidelbergHeidelbergGermany

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