Nutritional Factors Influencing IGF-1 Concentrations in Postmenopausal Women
Insulin-like growth factor-1 (IGF-1) is a critical factor in mediating the action of growth hormone and is also independently regulated. There has been great interest in the effects of growth hormone and IGF-1 in ageing (1, 2). Studies have concentrated on effects of muscle (1) and bone (3, 4). Differences in bone turnover rates seen in the elderly may be associated with individual variations in IGF-1 concentrations. Thus, age-related bone loss could, in part, be associated with reductions in IGF-1 concentrations. This is supported by studies in postmenopausal women, in whom recombinant human IGF-1 increased bone formation (5, 6) and increased bone resorption (5). These studies may suggest the need for long-term intervention trials of IGF-1 in osteoporotic patients to determine the efficacy of the treatment on preventing bone loss. Alternatively a nutritional approach may be able to alter IGF-1 concentration, as nutrient intake is a main regulator of IGF-1 production.
KeywordsZinc Deficiency Zinc Intake Growth Hormone Receptor Gene Recommended Dietary Intake Growth Hormone Signaling Pathway
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