Acquisition of Competence to Enter Meiotic Metaphase During Mammalian Spermatogenesis

  • Mary Ann Handel
  • John Cobb
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)


Little is known about factors that control the exit of the spermatocyte from meiosis I prophase to metaphase I (the G2/M transition). Before negotiating this critical cell-cycle transition, the spermatocyte must acquire competence to condense and segregate homologous chromosomes and must receive the appropriate signal(s) for entry into metaphase; these two requirements do not necessarily coincide temporally. The work of Wolgemuth and co-workers (see Chapter 6, this volume, for review) has provided ample evidence that a number of important and highly conserved cell-cycle proteins are in the right place at the right time, but it is not known how these proteins relate in either a mechanistic or regulatory sense to acquisition of meiotic competence and the G2/M cell-cycle transition in spermatocytes.


Okadaic Acid Meiotic Prophase Pachytene Spermatocyte Meiotic Metaphase Mammalian Spermatogenesis 
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© Springer-Verlag New York, Inc. 1998

Authors and Affiliations

  • Mary Ann Handel
  • John Cobb

There are no affiliations available

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