Modeling in the Analysis of the Processes of Uptake and Metabolism in the Whole Organ

  • James B. Bassingthwaighte
  • Carl A. Goresky
  • John H. Linehan


In the whole organ approach to cellular metabolism, the processes of capillary permeation, cellular entry, and intracellular reaction kinetics need to be examined in detail. The area is complex and varies from organ to organ, but there is a set of principles unifying the approaches to studies of these processes. The general approach to endogenous metabolism has been to carry out tracer studies within a variety of concentration steady states, and, for xenobiotics, to study the disposition of tracer within a variety of developed and maintained steady-state bulk concentrations.


Right Ventricular Myocardial Blood Flow Dilution Curve Indicator Dilution Residue Function 
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Copyright information

© Springer-Verlag New York Inc. 1998

Authors and Affiliations

  • James B. Bassingthwaighte
  • Carl A. Goresky
  • John H. Linehan

There are no affiliations available

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