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Modeling in the Analysis of the Processes of Uptake and Metabolism in the Whole Organ

  • James B. Bassingthwaighte
  • Carl A. Goresky
  • John H. Linehan

Abstract

In the whole organ approach to cellular metabolism, the processes of capillary permeation, cellular entry, and intracellular reaction kinetics need to be examined in detail. The area is complex and varies from organ to organ, but there is a set of principles unifying the approaches to studies of these processes. The general approach to endogenous metabolism has been to carry out tracer studies within a variety of concentration steady states, and, for xenobiotics, to study the disposition of tracer within a variety of developed and maintained steady-state bulk concentrations.

Keywords

Right Ventricular Myocardial Blood Flow Dilution Curve Indicator Dilution Residue Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1998

Authors and Affiliations

  • James B. Bassingthwaighte
  • Carl A. Goresky
  • John H. Linehan

There are no affiliations available

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