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Fibrin Glue and Topical Hemostasis in Cardiac Surgery

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Blood Conservation in Cardiac Surgery

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Abstract

Technical limitations of suturing have provided the impetus behind the search for improved methods of providing surgical hemostasis, sealing anastomoses, and bonding tissues. Incompatibility of the suture material with tissues may trigger an inflammatory response, resulting in tissue damage around the suture site. Sutures placed in fragile tissue can lead to necrosis and dehiscence of wounds. Technologies employed to partially overcome these problems include the use of improved suture materials, cauterization, metallic staples or clips, and a variety of adhesive/hemostatic agents. A surgical glue should provide atraumatic and expedient tissue sealing and bonding. The search for the ideal sealant prompted the development of both natural and synthetic products such as fibrin glue, collagen pledgets, absorbable gelatin sponges, oxidized cellulose, and cyanoacrylate derivatives. Fibrin glue is an excellent hemostatic agent as it is readily resorbed and has minimal tissue toxicity.

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Authors
  1. David C. Mair
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  2. John P. Miller
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  3. Paul D. Mintz
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Editor information

Editors and Affiliations

  1. Department of Cardiothoracic Surgery, The New York Hospital-Cornell Medical Center, 10021, New York, NY, USA

    Karl H. Krieger M.D. (Professor and Vice Chairman) & O. Wayne Isom M.D. (Professor and Chairman) (Professor and Vice Chairman) &  (Professor and Chairman)

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© 1998 Springer-Verlag New York, Inc.

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Mair, D.C., Miller, J.P., Mintz, P.D. (1998). Fibrin Glue and Topical Hemostasis in Cardiac Surgery. In: Krieger, K.H., Isom, O.W. (eds) Blood Conservation in Cardiac Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2180-7_17

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  • DOI: https://doi.org/10.1007/978-1-4612-2180-7_17

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-94908-6

  • Online ISBN: 978-1-4612-2180-7

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