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Fibrin Glue and Topical Hemostasis in Cardiac Surgery

  • David C. Mair
  • John P. Miller
  • Paul D. Mintz
Chapter

Abstract

Technical limitations of suturing have provided the impetus behind the search for improved methods of providing surgical hemostasis, sealing anastomoses, and bonding tissues. Incompatibility of the suture material with tissues may trigger an inflammatory response, resulting in tissue damage around the suture site. Sutures placed in fragile tissue can lead to necrosis and dehiscence of wounds. Technologies employed to partially overcome these problems include the use of improved suture materials, cauterization, metallic staples or clips, and a variety of adhesive/hemostatic agents. A surgical glue should provide atraumatic and expedient tissue sealing and bonding. The search for the ideal sealant prompted the development of both natural and synthetic products such as fibrin glue, collagen pledgets, absorbable gelatin sponges, oxidized cellulose, and cyanoacrylate derivatives. Fibrin glue is an excellent hemostatic agent as it is readily resorbed and has minimal tissue toxicity.

Keywords

Fibrin Glue Fibrin Sealant Mitral Valve Repair Oxidize Cellulose Needle Hole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc. 1998

Authors and Affiliations

  • David C. Mair
  • John P. Miller
  • Paul D. Mintz

There are no affiliations available

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