Application to Pharmacokinetic Analysis

  • Akifumi Yafune
Part of the Statistics for Engineering and Physical Science book series (ISS)

Abstract

Once a drug is administered to the human body, it undergoes the processes of absorption, distribution, metabolism and excretion. The area to study the kinetics of these processes is called pharmacokinetics.

Keywords

Ephedrine 

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References

  1. Akaike, H. (1973), “Information theory and an extension of the maximum likelihood principle,” 2nd International Symposium on Information Theory (Petrov, B. N. and Csaki, F. eds.), Akademiai Kiado, Budapest, 267–281. (Reproduced in Break-throughs in Statistics, Volume 1, S. Kotz and N. L. Johnson, eds., Springer Verlag ag, New York, 1992.)Google Scholar
  2. Davidon, W. C. (1968), “Variance algorithm for minimization,” Computer Journal, Vol. 10, 406–410.MathSciNetMATHCrossRefGoogle Scholar
  3. Ishiguro, M. and Akaike, H. (1989), “DALL: Davidon’s algorithm for log likelihood maximization — A FORTRAN subroutine for statistical model builders—,” Computer Science Monographs, No.25, The Institute of Statistical Mathematics, Tokyo.Google Scholar
  4. Rowland, M. and Tozer, T. N. (1995), Clinical Pharmacokinetics (third edition), Williams & Wilkins, Philadelphia.Google Scholar
  5. Sakamoto, Y., Ishiguro,M. and Kitagawa, G. (1986), Akaike Information Criterion Statistics, D. Reidel Publishing Company, Dordrecht.MATHGoogle Scholar
  6. Sheiner, L. B., Rosenberg, B. and Marathe, V. V. (1977), “Estimation of population characteristics of pharmacokinetic parameters from routine clinical data,” Journal of Pharmacokinetics and Biopharmaceutics, Vol. 5, 445–479.CrossRefGoogle Scholar
  7. Wagner, J. G. (1975), Fundamentals of Clinical Pharmacokinetics, Drug Intelligence Publications, Inc., Illinois.Google Scholar
  8. Yafune, A. and Ishiguro, M. (1992), “An exact application of maximum likelihood method to pharmacokinetic analysis,” Japanese Journal of Biometrics, Vol. 13, 5–14.Google Scholar
  9. Yafune, A. and Cyong, J. C. (1992), “Pharmacokinetics of ephedrine after oral administration of Sho-seiryu-to —Analysis in healthy male subjects—” Japanese Journal of Oriental Medicine, Vol. 43, 275–283.Google Scholar
  10. Yamaoka, K., Tanaka, H., Okumura, K., Yasuhara, M. and Hori, R. (1986), “An analysis program MULTI(ELS) based on extended nonlinear least squares method for microcomputers,” Journal of Pharmacobio-Dynamics, Vol. 9, 161–173.Google Scholar

Copyright information

© Springer-Verlag New York, Inc. 1999

Authors and Affiliations

  • Akifumi Yafune
    • 1
  1. 1.Bio-Iatric CenterThe Kitasato InstituteTokyoJapan

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