Mast Cell Apoptosis and Its Regulation

  • Yoseph A. Mekori
  • Karin Hartmann
  • Dean D. Metcalfe


Mast cells are found almost exclusively in tissues in which they reach phenotypic maturation under certain microenvironmental influences.1,2 The number of mast cells in these tissues under normal conditions is relatively constant.3 Mast cell hyperplasia occurs, however, in several conditions including host responses to parasites and neoplasia; in tissue repair and fibrosis; and in chronic inflammatory conditions associated with the pathology of diseases such as Crohn’s disease and rheumatoid arthritis.4,5 The growth factors required for mast cell proliferation or maturation are well studied, and include IL-3 and the c-kit ligand stem cell factor (SCF) as the principal growth-promoting cytokines. However, less is known about the mechanisms that regulate the viability of mature mast cells and permit mast cell apoptosis.


Mast Cell Nerve Growth Factor Stem Cell Factor Human Mast Cell Mast Cell Number 
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Copyright information

© Springer-Verlag New York, Inc. 1999

Authors and Affiliations

  • Yoseph A. Mekori
  • Karin Hartmann
  • Dean D. Metcalfe

There are no affiliations available

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