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Factors That Affect Human Mast Cell and Basophil Growth

  • Chapter
Signal Transduction in Mast Cells and Basophils

Abstract

Mast cells and basophils are specialized effector cells of the immune system and both cells express FcεRI, stain metachromatically, synthesize a number of cytokines, and have comparable amounts of histamine. It has been assumed that the two cells share a common progenitor, or that one cell originates from the other. This notion is unlikely to be correct because basophils appear to represent a terminally differentiated cell rather than a peripheral blood mast cell precursor. In addition, mast cells and basophils have distinguishing features with respect to morphology, mediator content, response to distinct cytokines, and specific cell-surface molecules that identify these two cells as distinct.

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Authors
  1. Lixin Li
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  2. Xiao-Tong Zhang
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  3. Steven A. Krilis
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Editors and Affiliations

  1. Department of Biochemistry, Haddasah Medical School, Hebrew University, Jerusalem, 91120, Israel

    Ehud Razin

  2. Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bathesda, MD, 20892-1820, USA

    Juan Rivera

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Li, L., Zhang, XT., Krilis, S.A. (1999). Factors That Affect Human Mast Cell and Basophil Growth. In: Razin, E., Rivera, J. (eds) Signal Transduction in Mast Cells and Basophils. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2154-8_5

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  • DOI: https://doi.org/10.1007/978-1-4612-2154-8_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7435-3

  • Online ISBN: 978-1-4612-2154-8

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