Role of ICRAC in the Regulation of Secretion
Signal transduction events mediate and regulate secretion in specialized cells, including mast cells. Secretion occurs when vesicles or granules containing molecular transmitters fuse with a specific region of the plasma membrane and release their contents into the cleft near an adjacent cell or into the extracellular milieu (i.e., bloodstream). This process is mediated by various messengers, which transfer a signal from the plasma membrane to these intracellular vesicles that they should move or fuse. Because secretion is so important for cellular communication and function, this process is also highly regulated by signal transduction intermediates and pathways. This chapter focuses on one aspect of this regulation, namely, the role of calcium influx through calcium-release-activated calcium current (ICRAC) channels in regulating the secretory event in mast cells.
KeywordsMast Cell Nerve Growth Factor Calcium Influx Pipette Solution Mucosal Mast Cell
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