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Inflammatory Breast Cancer

  • Chapter
Breast Cancer

Part of the book series: M.D. Anderson Solid Tumor Oncology Series ((MDA))

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Abstract

Inflammatory breast carcinoma (IBC) is an uncommon disease accounting for only 1–6% of all breast cancers.1 [The criteria for the diagnosis of IBC at The University of Texas M. D. Anderson Cancer Center (MDACC) are development of erythema (associated with increased heat), edema or peau d’orange (from exaggerated hair-follicle pits due to tumor blockage of lymphatic channels), and wheals or ridging of the skin of the breast mound (caused by lymphatics filled with tumor cells) within 3 months of presentation and biopsy-proved adenocarcinoma of the breast.] A clinical history of a rapid onset of inflammatory changes of the breast skin is essential for a diagnosis of IBC. It is important to differentiate patients with true IBC from those with locally advanced breast carcinoma with secondary skin involvement, as the latter group may have a better prognosis.2,3

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References

  1. Levine PH, Steinhorn SC, Ries LG, et al. Inflammatory breast cancer: the experience of the Surveillance, Epidemiology, and End Results (SEER) program. J Natl Cancer Inst 1985;74:291–297.

    PubMed  CAS  Google Scholar 

  2. Haagensen CD. Diseases of the Breast, 2nd ed. Philadelphia: Saunders, 1971;576–584.

    Google Scholar 

  3. Sherry M, Johnson D, Page EI, et al. Inflammatory carcinoma of the breast: clinical review and summary of the Vanderbilt experience with multimodality therapy. Am J Med 1985;79:355–364.

    Article  PubMed  CAS  Google Scholar 

  4. Ellis DL, Teitelbaum SL. Inflammatory carcinoma of the breast: a pathologic definition. Cancer 1974;33:1045–1047.

    Article  PubMed  CAS  Google Scholar 

  5. Saltzstein SL. Clinically occult inflammatory carcinoma of the breast. Cancer 1974;34:382–388.

    Article  PubMed  CAS  Google Scholar 

  6. Lucas FV, Mesa-Perez C. Inflammatory carcinoma of the breast. Cancer 1978;41:1595–1605.

    Article  PubMed  CAS  Google Scholar 

  7. Delarue JC, May-Levin F, Mouriesse H, et al. Oestrogen and progesterone cytosolic receptors in clinically inflammatory tumors of the human breast. Br J Cancer 1981;44:911–916.

    Article  PubMed  CAS  Google Scholar 

  8. Harvey H, Lipton A, Lawrence BV, et al. Estrogen receptors in inflammatory breast carcinoma. J Surg Oncol 1982;21:42–44.

    Article  PubMed  CAS  Google Scholar 

  9. Paradiso A, Tommasi S, Brandi M, et al. Cell kinetics and hormonal receptor status in inflammatory breast carcinoma: comparison with locally advanced disease. Cancer 1989;64:1922–1927.

    Article  PubMed  CAS  Google Scholar 

  10. Beahrs O, Henson D, Hatter R (eds). Manual for Staging of Cancer, 3rd ed. Philadelphia: Lippincott, 1988;145–150.

    Google Scholar 

  11. Hermanek P, Sobin LH (eds). TNM Classification of Malignant Tumors: UICC International Union Against Cancer, 4th ed. Berlin: Springer, 1987;93–99.

    Google Scholar 

  12. Denoix P. Treatment of malignant breast tumors. Recent Results Cancer Res, 1970;32:3–11.

    Google Scholar 

  13. Fletcher GH, Montague ED. Radical irradiation of advanced breast cancer. J Roentgenol 1965;93:573–584.

    CAS  Google Scholar 

  14. Barker JL, Nelson JA, Montague ED. Inflammatory carcinoma of the breast. Radiology 1976;121:173–176.

    PubMed  CAS  Google Scholar 

  15. Lee B, Tannenbaum N. Inflammatory carcinoma of the breast: a report of twenty-eight (28) cases from the breast clinic of Memorial Hospital. Surg Gynecol Obstet 1924;39:580–595.

    Google Scholar 

  16. Taylor G, Meltzer A. Inflammatory carcinoma of the breast. Am J Cancer 1938;33:33–19.

    Google Scholar 

  17. Treves N. The inoperability of inflammatory carcinoma of the breast. Surg Gynecol Obstet 1959;109:240–242.

    PubMed  CAS  Google Scholar 

  18. Byrd B Jr, Stevenson S Jr. Management of inflammatory breast cancer. South Med J 1960;53:945–948.

    Article  PubMed  Google Scholar 

  19. Robbins GF, Shah J, Rosen P, et al. Inflammatory carcinoma of the breast. Surg Clin North Am 1974;54:801–810.

    PubMed  CAS  Google Scholar 

  20. Bozzetti F, Saccozzi R, DeLena M, et al. Inflammatory cancer of the breast: analysis of 114 cases. J Surg Oncol 1981;18:355–361.

    Article  PubMed  CAS  Google Scholar 

  21. Droulias S, Sewell C, McSweeney M, et al. Inflammatory carcinoma of the breast: a correlation of clinical, radiologic, and pathologic findings. Ann Surg 1976;184:217–222.

    Article  PubMed  CAS  Google Scholar 

  22. Meyer AC, Dockerty MB, Harrington SW. Inflammatory carcinoma of the breast. Surg Gynecol Obstet 1948;87:417–424.

    PubMed  CAS  Google Scholar 

  23. Chris SM. Inflammatory carcinoma of the breast: a result of 20 cases and a review of the literature. Br J Surg 1950;38:163–174.

    Article  PubMed  CAS  Google Scholar 

  24. Rogers CS, Fitts WT. Inflammatory carcinoma of the breast: a critique of therapy. Surgery 1956;39:367–370.

    PubMed  CAS  Google Scholar 

  25. Dao TL, McCarthy JD. Treatment of inflammatory carcinoma of the breast. Surg Gynecol Obstet 1957;105:289–294.

    PubMed  CAS  Google Scholar 

  26. Richards G, Lewison E. Inflammatory carcinoma of the breast. Surg Gynecol Obstet 1961;113:729–732.

    PubMed  Google Scholar 

  27. Krutchik AN, Buzdar AU, Blumenschein GR, et al. Combined chemoimmunotherapy and radiation therapy of inflammatory breast cancer. J Surg Oncol 1979;11:325–332.

    Article  PubMed  CAS  Google Scholar 

  28. Koh EH, Buzdar AU, Ames FC, et al. Inflammatory carcinoma of the breast: result of a combined-modality approach—M. D. Anderson Cancer Center experience. Cancer Chemother Pharmacol 1990;27:94–100.

    Article  PubMed  CAS  Google Scholar 

  29. Singletary SE, Ames FC, Buzdar AU. The management of inflammatory breast cancer. World J Surg 1994;18:87–92.

    Article  PubMed  CAS  Google Scholar 

  30. Fleming RYD, Asmar L, Buzdar AU, et al. Effectiveness of mastectomy by response to induction chemotherapy for control in inflammatory breast cancer. Ann Surg Oncol 1997;4:452–461.

    Article  PubMed  CAS  Google Scholar 

  31. Barker JL, Montague ED, Peters LJ. Clinical experience with irradiation of inflammatory carcinoma of the breast with and without elective chemotherapy. Cancer 1981;47:2537–2542.

    Article  PubMed  Google Scholar 

  32. Buzdar AU, Montague ED, Barker JL, et al. Management of inflammatory carcinoma of breast with combined modality approach—an update. Cancer 1981;47:2537–2542.

    Article  PubMed  CAS  Google Scholar 

  33. Wiseman C, Jessup JM, Smith TL, et al. Inflammatory breast cancer treated with surgery, chemotherapy and allogeneic tumor cell/BCG immunotherapy. Cancer 1982;49:1266–1271.

    Article  PubMed  CAS  Google Scholar 

  34. Thoms WW, McNeese MD, Fletcher GH, et al. Multimodal treatment for inflammatory breast cancer. Int J Radiat Oncol Biol Phys 1989;17:739–745.

    Article  PubMed  Google Scholar 

  35. Swain SM, Lippman ME. Treatment of patients with inflammatory breast cancer. In: DeVita V Jr, Hellman S, Rosenberg S (eds). Philadelphia: Lippincott, 1989;129–150.

    Google Scholar 

  36. Armstrong DK, Fetting JH, Davidson NE, et al. Sixteen week dose intense chemotherapy for inoperable, locally advanced breast cancer. Breast Cancer Res Treat 1993;28:277–284.

    Article  PubMed  CAS  Google Scholar 

  37. Antman K, Bearman SI, Davidson N, et al. Dose intense therapy in breast cancer: current status. In: Gale RP, Champlin RE (eds) New Strategies in Bone Marrow Transplantation. New York: Liss, 1990;423–426.

    Google Scholar 

  38. Holmes FA, Walters RS, Theriault RL, et al. Phase II trial of taxol: an active drug in metastatic breast cancer. J Natl Cancer Inst 1991;83:1797–1805.

    PubMed  CAS  Google Scholar 

  39. Chevallier B, Fumoleau P, Kerbrat P, et al. Docetaxel is a major cytotoxic drug for the treatment of advanced breast cancer: a phase II trial of the Clinical Screening Cooperative Group of the European Organization for Research and Treatment of Cancer. J Clin Oncol 1995;13:314–322.

    PubMed  CAS  Google Scholar 

  40. Buzdar AU, Hortobagyi GN, Asmar L, et al. Prospective randomized trial of paclitaxel (TAX) alone versus 5-fluorouracil, doxorubicin, cyclophosphamide (FAC) as an induction therapy in patients with operable breast cancer. Sem Oncol 1997;24:S17–31.

    CAS  Google Scholar 

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Authors
  1. R. Y. Declan Fleming
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  2. S. Eva Singletary
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Editors and Affiliations

  1. Surgical Breast Section, Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Box 106, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    S. Eva Singletary M.D., FACS (Professor of Surgery, Chief) (Professor of Surgery, Chief)

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© 1999 Springer-Verlag New York, Inc.

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Fleming, R.Y.D., Singletary, S.E. (1999). Inflammatory Breast Cancer. In: Singletary, S.E. (eds) Breast Cancer. M.D. Anderson Solid Tumor Oncology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2146-3_23

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  • DOI: https://doi.org/10.1007/978-1-4612-2146-3_23

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7432-2

  • Online ISBN: 978-1-4612-2146-3

  • eBook Packages: Springer Book Archive

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