The Development of Approaches Based on Gene Therapy to Improve Muscle Healing Following Injury

  • Jacques Ménétrey
  • Channarong Kasemkijwattana
  • Charles S. Day
  • Patrick Bosch
  • Morey S. Moreland
  • Freddie H. Fu
  • Johnny Huard
Part of the Methods in Bioengineering book series (MB)


Muscle injuries are common, with an incidence varying from 10% to 55% of all injuries sustained in sports (Lehto and Jarvinen 1991). Muscle injuries are divided into 2 types: a shearing injury, in which both the myofibers and the connective tissue framework are torn, or an in situ injury, in which only the myofibers are damaged and the basal lamina and connective tissue sheaths do not undergo significant harm. Shearing injuries, the most frequent muscle injuries related to sports, may be lacerations, contusions, or strains, depending on the mechanism of injury (Lehto and Jarvinen 1991). Contusion is sustained through a significant compressive force to the muscle, such as a direct blow, a common occurrence in contact sports. A strain occurs when a forceful eccentric contraction is applied to an overstretched muscle, especially in jumping or sprinting (Garrett, Jr. 1990; Lehto and Jarvinen 1991). Injury is common near the musculotendinous junction (MTJ) of a superficial muscle that crosses 2 joints, such as the rectus femoris, semitendinosus, and gastrocnemius muscles. Though rather rare in sports, muscle laceration is a dramatic injury that consistently incapacitates athletes for long periods of time and often jeopardizes their professional careers.


Nerve Growth Factor Satellite Cell Herpes Simplex Virus Type Duchenne Muscular Dystrophy Compartment Syndrome 
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Copyright information

© Birkhäuser Boston 2000

Authors and Affiliations

  • Jacques Ménétrey
  • Channarong Kasemkijwattana
  • Charles S. Day
  • Patrick Bosch
  • Morey S. Moreland
  • Freddie H. Fu
  • Johnny Huard

There are no affiliations available

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