Abstract
Although hormonal replacement therapy (HRT) for the postmenopausal woman has been studied and promoted for years, interest in the possibility of male HRT is a relatively new development. Reasons for growing enthusiasm in this area include an increasing body of data supporting an age-related decline in testosterone production and the increasing number of older adults who are eager to maintain robust health and avoid dysfunction and frailty.
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References
Vermeulen A. Clinical review 24: androgens in the aging male. J Clin Endocrinol Metab 1991; 73: 221 – 24.
Morley JE, Kaiser FE, Perry HM, Patrick P, Morley PMK, Stauber PM, et al. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism 1997;46:410–13.
Gray A, Berlin JA, McKinlay JB, Longcope C. An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis. J Clin Epidemiol 1991;44:671–84.
Nankin HR, Calkins JH. Decreased bioavailable testosterone in aging normal and impotent men. J Clin Endocrinol Metab 1986;63:1418–20.
Tenover JL . Trophic factors and male hormone replacement. In: Hazzard WR, Blass JP, Ettinger WH, Halter JB, Ouslander JG, ed. Principles of geriatric medicine and gerontology. Fourth ed. New York: McGraw-Hill, 1999:1029–40.
Tenover JS . Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 1992;75:1092–98.
Morley JE, Perry HM, Kaiser FE, Kraenzle D, Jensen J, Houston K, et al. Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc 1993;41:149–52.
Katznelson L, Finkelstein JS, Schoenfeld DA, Rosenthal DI, Anderson EJ, Klibanski A. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab 1996;81:4358–65.
Sih R, Morley JE, Kaiser FE, Perry HM, Patrick P, Ross C. Testosterone replace-ment in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab 1997;82:1661–67.
Marin P, Holmang S, Gustafsson C, Jonsson L, Kvist H, Elander A, et al. Androgen treatment of abdominally obese men. Obesity Res 1993;1:245–51.
Urban RJ, Bodenburg YH, Gilkison C, Foxworth J. Coggan AR, Wolfe RR, et al. Testosterone administration in elderly men increases skeletal muscle strength and protein synthesis. Am J Physiol 1995;269:E820–26.
Greenspan SL, Oppenheim DS, Klibanski A. Importance of gonadal steroids to bone mass in men with hyperprolactinemic hypogonadism. Ann Intern Med 1989;110:526–31.
Jackson JA, Kleerekoper M, Parfitt AM, Rao DS, Villanueva AR, Frame B. Bone histomorphometry in hypogonadal and eugonadal men with spinal osteoporosis. J Clin Endocrinol Metab 1967;65:53–58.
Reid IR, Wattie DJ, Evans MC, Stapleton JC. Testosterone therapy in gluco-corticoid treated men. Arch Intern Med 1996;156:1173–77.
Carani CM, Zini D, Baldini A. Effects of androgen treatment in impotent men with normal and low levels of free testosterone. Arch Sex Behav 1990;19:223–34.
Guay AT, Bansal S, Heatley GJ. Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo-controlled trial with clomiphene citrate. J Clin Endocrinol Metab 1995;80:3546–52.
O’Carroll R, Bancroft J. Testosterone therapy for low sexual interest and erectile dysfunction in men: a controlled study. Br J Psychiatr 1984;145:146–51.
Bagatell CJ, Bremner WJ. Androgen and progestagen effects on plasma lipids. Prog Cardiovasc Dis 1995;38:255–71.
Tenover JL . The male climacteric: fact or fiction? In: Morales A, ed. Erectile dys-function. London: Martin Dunitz, 1998:39–48.
Tenover JL . Effects of androgen supplementation in the aging male. In: Oddens BJ, Vermeulen A, eds. Androgens and the aging male. New York: Parthenon, 1996:91–204.
Sandblom RE, Matsumoto AM, Schoene RB, Lee KA, Giblin ED, Bremner WJ, et al. Obstructive sleep apnea syndrome induced by testosterone administration. N Engl J Med 1983;308:508–10.
Santamaria JD, Prior JC, Fleetham JA. Reversible reproductive dysfunction in men with obstructive sleep apnoea. Clin Endocrinol (Oxf) 1998;28:461–70.
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Tenover, J.L. (2000). HRT for the Aging Male: A Therapy That Has Come of Age?. In: Goldberg, E. (eds) The Testis. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2106-7_8
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DOI: https://doi.org/10.1007/978-1-4612-2106-7_8
Publisher Name: Springer, New York, NY
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