Characterization of the Testicular Histone-Binding Protein, NASP
The nuclear autoantigenic sperm protein (NASP) was first recognized because of its autoantigenicity in males and immunological cross-reactivity with the sperm-specific autoantigen RSA (1). NASP was initially described as a highly immunogenic testis and sperm-specific protein, which was present in the postacrosomal region of mature spermatozoa and in the nucleus of developing spermatogenic cells (1,2). From DNA sequence comparisons, NASP appears to have evolved from the N1/N2 gene expressed in oocytes of Xenopus laevis (3,4). Indeed, the 3’ untranslated sequence identity between the rabbit and Xenopus mRNAs reaches approximately 60%, implying that mammalian NASP is a true homologue of N1/N2.
KeywordsSpermatogenic Cell Round Spermatid Primary Spermatocyte Xenopus Laevis Oocyte Chromatin Assembly Factor
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